YBL004W / UTP20

Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL004W / UTP20

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-6.93|P-value:1.06E-12 ID:SGTC_74|Compound:000s-0487|FD-Score:3.38|P-value:3.48E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-11.30|P-value:9.77E-31 ID:SGTC_141|Compound:0443-0274|FD-Score:-10.90|P-value:2.26E-28 ID:SGTC_163|Compound:1327-0036|FD-Score:3.21|P-value:6.40E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:4.42|P-value:4.39E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:4.24|P-value:1.01E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:3.27|P-value:5.18E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.23|P-value:1.07E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:3.11|P-value:9.00E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:17.30|P-value:1.33E-68 ID:SGTC_651|Compound:3253-0966|FD-Score:3.17|P-value:7.38E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.86|P-value:5.15E-7 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.23|P-value:5.18E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.27|P-value:5.17E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.12|P-value:7.44E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.17|P-value:1.39E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.23|P-value:5.97E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.27|P-value:5.13E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.88|P-value:4.86E-5 ID:SGTC_1721|Compound:st082152|FD-Score:4.21|P-value:1.15E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.58|P-value:1.35E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.39|P-value:3.35E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.79|P-value:7.12E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-3.96|P-value:2.84E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-5.04|P-value:1.58E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.30|P-value:4.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.51|P-value:1.82E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.12|P-value:1.75E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.36|P-value:3.77E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.81|P-value:6.45E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.78|P-value:7.75E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-4.26|P-value:7.54E-6 ID:SGTC_2428|Compound:5615643|FD-Score:3.11|P-value:8.94E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.39|P-value:2.80E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.85|P-value:4.51E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.57|P-value:1.41E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.49|P-value:2.24E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.09|P-value:8.46E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.96|P-value:3.44E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.14|P-value:1.58E-5 ID:SGTC_2956|Compound:9076196|FD-Score:5.06|P-value:1.78E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-4.46|P-value:2.92E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.71|P-value:9.59E-5 ID:SGTC_2997|Compound:9067075|FD-Score:3.74|P-value:8.75E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.25|P-value:5.47E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-11.40|P-value:4.77E-31 ID:SGTC_3102|Compound:9121669|FD-Score:3.44|P-value:2.78E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.41|P-value:2.67E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.65|P-value:1.25E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.86|P-value:5.29E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-3.76|P-value:6.77E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-3.20|P-value:5.65E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.73|P-value:8.92E-5 ID:SGTC_3337|Compound:9144342|FD-Score:-3.08|P-value:8.53E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-6.93|P-value:1.06E-12 ID:SGTC_74|Compound:000s-0487|FD-Score:3.38|P-value:3.48E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-11.30|P-value:9.77E-31 ID:SGTC_141|Compound:0443-0274|FD-Score:-10.90|P-value:2.26E-28 ID:SGTC_163|Compound:1327-0036|FD-Score:3.21|P-value:6.40E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:4.42|P-value:4.39E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:4.24|P-value:1.01E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:3.27|P-value:5.18E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.23|P-value:1.07E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:3.11|P-value:9.00E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:17.30|P-value:1.33E-68 ID:SGTC_651|Compound:3253-0966|FD-Score:3.17|P-value:7.38E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.64|P-value:1.26E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.86|P-value:5.15E-7 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.23|P-value:5.18E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.27|P-value:5.17E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.12|P-value:7.44E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:4.17|P-value:1.39E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.23|P-value:5.97E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.27|P-value:5.13E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.88|P-value:4.86E-5 ID:SGTC_1721|Compound:st082152|FD-Score:4.21|P-value:1.15E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.58|P-value:1.35E-4 ID:SGTC_1850|Compound:st056238|FD-Score:3.39|P-value:3.35E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.79|P-value:7.12E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-3.96|P-value:2.84E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-5.04|P-value:1.58E-7 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.30|P-value:4.02E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.51|P-value:1.82E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.12|P-value:1.75E-5 ID:SGTC_2326|Compound:6164455|FD-Score:3.36|P-value:3.77E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.81|P-value:6.45E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.78|P-value:7.75E-7 ID:SGTC_2425|Compound:5628681|FD-Score:-4.26|P-value:7.54E-6 ID:SGTC_2428|Compound:5615643|FD-Score:3.11|P-value:8.94E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.39|P-value:2.80E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.85|P-value:4.51E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.57|P-value:1.41E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.49|P-value:2.24E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.09|P-value:8.46E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.96|P-value:3.44E-5 ID:SGTC_2860|Compound:9025725|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.14|P-value:1.58E-5 ID:SGTC_2956|Compound:9076196|FD-Score:5.06|P-value:1.78E-7 ID:SGTC_2957|Compound:9076800|FD-Score:-4.46|P-value:2.92E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.71|P-value:9.59E-5 ID:SGTC_2997|Compound:9067075|FD-Score:3.74|P-value:8.75E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.25|P-value:5.47E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-11.40|P-value:4.77E-31 ID:SGTC_3102|Compound:9121669|FD-Score:3.44|P-value:2.78E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.41|P-value:2.67E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.65|P-value:1.25E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.86|P-value:5.29E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-3.76|P-value:6.77E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-3.20|P-value:5.65E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.73|P-value:8.92E-5 ID:SGTC_3337|Compound:9144342|FD-Score:-3.08|P-value:8.53E-4

Top fitness defect scores for YBL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_617 3770-0098 17.30 35.0 µM 1.33E-68 exosome 1 2.10E-67 3.16
2 SGTC_2956 9076196 5.06 2.5 µM 1.78E-7 2 2.10E-7 0.83
3 SGTC_774 k060-0086 4.86 136.0 µM 5.15E-7 2 5.97E-7 0.56
4 SGTC_2363 9053361 4.81 176.0 µM 6.45E-7 Golgi 7 7.44E-7 0.25
5 SGTC_2366 9070441 4.78 60.6 µM 7.75E-7 4 8.92E-7 0.48
6 SGTC_324 1315-0088 4.42 19.6 µM 4.39E-6 RSC & ERG11 9 4.92E-6 0.20
7 SGTC_328 k915-0120 4.24 63.5 µM 1.01E-5 TSC3-RPN4 3 1.12E-5 0.52
8 SGTC_536 3852-0578 4.23 10.6 µM 1.07E-5 1 1.19E-5 0.50
9 SGTC_1721 st082152 4.21 9.3 µM 1.15E-5 60S ribosome export 7 1.27E-5 0.08
10 SGTC_1157 4092-0394 4.17 27.6 µM 1.39E-5 3 1.53E-5 0.45
11 SGTC_2949 9072542 4.14 2.2 µM 1.58E-5 TSC3-RPN4 13 1.74E-5 0.29
12 SGTC_2067 5224629 4.12 34.1 µM 1.75E-5 9 1.92E-5 0.03
13 SGTC_2754 granisetron 3.96 64.0 µM 3.44E-5 6 3.74E-5 0.10
14 SGTC_1266 0828-0227 3.88 32.9 µM 4.86E-5 12 5.25E-5 0.02
15 SGTC_3290 9121031 3.86 71.4 µM 5.29E-5 3 5.71E-5 0.38
16 SGTC_1911 st060208 3.79 74.3 µM 7.12E-5 10 7.65E-5 0.18
17 SGTC_2997 9067075 3.74 71.4 µM 8.75E-5 unfolded protein response 24 9.38E-5 0.06
18 SGTC_3330 9141424 3.73 71.4 µM 8.92E-5 amide catabolism 3 9.55E-5 0.13
19 SGTC_2963 9082507 3.71 9.0 µM 9.59E-5 10 1.03E-4 0.05
20 SGTC_3233 9132340 3.65 49.5 µM 1.25E-4 14 1.33E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.09E-40 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.225 8.85E-40 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.179 1.34E-25 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.171 1.58E-23 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.170 3.71E-23 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.170 4.15E-23 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.162 4.42E-21 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.155 1.74E-19 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.153 5.14E-19 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.153 6.05E-19 YGR090W UTP22 het Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
0.151 1.31E-18 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.149 3.16E-18 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.147 1.13E-17 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.143 6.66E-17 YER147C SCC4 het Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
0.141 2.19E-16 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein