YBL010C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL010C / YBL010C

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:4.13|P-value:1.59E-5 ID:SGTC_57|Compound:miconazole|FD-Score:3.57|P-value:1.58E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.45|P-value:1.97E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:11.50|P-value:4.56E-31 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.59|P-value:9.08E-9 ID:SGTC_252|Compound:miconazole|FD-Score:5.25|P-value:6.36E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:9.02|P-value:5.23E-20 ID:SGTC_320|Compound:4092-0846|FD-Score:4.62|P-value:1.61E-6 ID:SGTC_447|Compound:ml7|FD-Score:3.62|P-value:1.33E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.21|P-value:6.07E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.80|P-value:6.54E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.18|P-value:6.68E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.56|P-value:1.08E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.37|P-value:3.51E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:8.31|P-value:2.94E-17 ID:SGTC_693|Compound:4161-2696|FD-Score:3.16|P-value:7.17E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.85|P-value:5.15E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.15|P-value:7.61E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.36|P-value:3.60E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.84|P-value:5.49E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.12|P-value:8.47E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:9.38|P-value:1.75E-21 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.82|P-value:5.88E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.13|P-value:8.16E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.30|P-value:4.55E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-4.68|P-value:1.27E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.57|P-value:1.62E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.32|P-value:4.16E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.34|P-value:2.37E-17 ID:SGTC_1754|Compound:st042065|FD-Score:5.40|P-value:2.75E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.08|P-value:9.59E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.31|P-value:4.40E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.87|P-value:4.67E-7 ID:SGTC_1846|Compound:st056244|FD-Score:-3.41|P-value:3.02E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.94|P-value:3.71E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.79|P-value:2.75E-9 ID:SGTC_2036|Compound:5160441|FD-Score:4.96|P-value:2.99E-7 ID:SGTC_2194|Compound:5927483|FD-Score:-3.12|P-value:8.44E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.09|P-value:9.33E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.54|P-value:1.78E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.54|P-value:1.77E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.22|P-value:5.78E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.19|P-value:6.70E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.22|P-value:1.87E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:7.12|P-value:3.76E-13 ID:SGTC_2880|Compound:9042983|FD-Score:3.09|P-value:9.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.12|P-value:1.67E-5 ID:SGTC_3018|Compound:9082602|FD-Score:9.48|P-value:6.90E-22 ID:SGTC_3037|Compound:9091026|FD-Score:3.73|P-value:8.61E-5 ID:SGTC_3222|Compound:9128301|FD-Score:4.19|P-value:1.22E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.66|P-value:1.18E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:4.13|P-value:1.59E-5 ID:SGTC_57|Compound:miconazole|FD-Score:3.57|P-value:1.58E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:5.45|P-value:1.97E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:11.50|P-value:4.56E-31 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.59|P-value:9.08E-9 ID:SGTC_252|Compound:miconazole|FD-Score:5.25|P-value:6.36E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:9.02|P-value:5.23E-20 ID:SGTC_320|Compound:4092-0846|FD-Score:4.62|P-value:1.61E-6 ID:SGTC_447|Compound:ml7|FD-Score:3.62|P-value:1.33E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.21|P-value:6.07E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.80|P-value:6.54E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.18|P-value:6.68E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:5.56|P-value:1.08E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:-3.37|P-value:3.51E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:8.31|P-value:2.94E-17 ID:SGTC_693|Compound:4161-2696|FD-Score:3.16|P-value:7.17E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:4.85|P-value:5.15E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.15|P-value:7.61E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.36|P-value:3.60E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.84|P-value:5.49E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.12|P-value:8.47E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:9.38|P-value:1.75E-21 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.82|P-value:5.88E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.13|P-value:8.16E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.30|P-value:4.55E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-4.68|P-value:1.27E-6 ID:SGTC_1677|Compound:st019204|FD-Score:3.57|P-value:1.62E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.32|P-value:4.16E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.34|P-value:2.37E-17 ID:SGTC_1754|Compound:st042065|FD-Score:5.40|P-value:2.75E-8 ID:SGTC_1760|Compound:st045453|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.08|P-value:9.59E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.31|P-value:4.40E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.87|P-value:4.67E-7 ID:SGTC_1846|Compound:st056244|FD-Score:-3.41|P-value:3.02E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.94|P-value:3.71E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.79|P-value:2.75E-9 ID:SGTC_2036|Compound:5160441|FD-Score:4.96|P-value:2.99E-7 ID:SGTC_2194|Compound:5927483|FD-Score:-3.12|P-value:8.44E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.09|P-value:9.33E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.54|P-value:1.78E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.54|P-value:1.77E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.49|P-value:2.15E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.22|P-value:5.78E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.19|P-value:6.70E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.22|P-value:1.87E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:7.12|P-value:3.76E-13 ID:SGTC_2880|Compound:9042983|FD-Score:3.09|P-value:9.23E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.12|P-value:1.67E-5 ID:SGTC_3018|Compound:9082602|FD-Score:9.48|P-value:6.90E-22 ID:SGTC_3037|Compound:9091026|FD-Score:3.73|P-value:8.61E-5 ID:SGTC_3222|Compound:9128301|FD-Score:4.19|P-value:1.22E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.66|P-value:1.18E-4

Top fitness defect scores for YBL010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 11.50 4.5 µM 4.56E-31 endomembrane recycling 15 1.12E-30
2 SGTC_3018 9082602 9.48 49.5 µM 6.90E-22 15 1.29E-21
3 SGTC_1072 oxiconazole 9.38 14.9 nM 1.75E-21 ergosterol depletion effects on membrane 9 3.23E-21
4 SGTC_312 4092-0653 9.02 6.8 µM 5.23E-20 ergosterol depletion effects on membrane 15 9.22E-20
5 SGTC_1750 st081859 8.34 2.4 µM 2.37E-17 endomembrane recycling 64 3.86E-17
6 SGTC_689 0833-0039 8.31 98.0 µM 2.94E-17 ergosterol depletion effects on membrane 4 4.77E-17
7 SGTC_2778 tioconazole 7.12 65.1 nM 3.76E-13 ergosterol depletion effects on membrane 24 5.40E-13
8 SGTC_2688 kanamycin b 6.22 96.7 µM 1.87E-10 calcium & mitochondrial duress 146 2.48E-10
9 SGTC_2006 4011487 5.79 200.0 µM 2.75E-9 endomembrane recycling 46 3.52E-9
10 SGTC_221 trifluoperazine 5.59 10.3 µM 9.08E-9 NEO1-PIK1 139 1.15E-8
11 SGTC_649 1123-0311 5.56 367.0 µM 1.08E-8 endomembrane recycling 30 1.36E-8
12 SGTC_201 4262-0159 5.45 12.8 µM 1.97E-8 ergosterol depletion effects on membrane 21 2.46E-8
13 SGTC_1754 st042065 5.40 16.1 µM 2.75E-8 NEO1-PIK1 109 3.42E-8
14 SGTC_252 miconazole 5.25 1.3 nM 6.36E-8 ergosterol depletion effects on membrane 23 7.81E-8
15 SGTC_2036 5160441 4.96 105.0 µM 2.99E-7 NEO1 55 3.60E-7
16 SGTC_1842 st055362 4.87 61.2 µM 4.67E-7 3 5.59E-7
17 SGTC_705 1124-0212 4.85 310.0 µM 5.15E-7 6 6.16E-7
18 SGTC_320 4092-0846 4.62 5.3 µM 1.61E-6 ergosterol depletion effects on membrane 32 1.90E-6
19 SGTC_3222 9128301 4.19 49.5 µM 1.22E-5 60S ribosome export 23 1.40E-5
20 SGTC_32 0928-0142 4.13 34.1 µM 1.59E-5 TSC3-RPN4 6 1.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.615 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.589 3.16E-313 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.585 4.22E-307 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.583 1.04E-304 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.472 2.60E-185 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.446 3.32E-163 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.442 1.77E-160 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.422 4.83E-145 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.400 7.78E-129 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.357 1.28E-101 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.356 7.00E-101 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.338 2.63E-90 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.332 3.89E-87 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.320 1.42E-80 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.314 8.53E-78 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p