YBL015W / ACH1

Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL015W / ACH1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.28|P-value:3.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.04|P-value:9.45E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.17|P-value:4.57E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.35|P-value:2.86E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.12|P-value:1.18E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.86|P-value:3.71E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.04|P-value:9.20E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.16|P-value:4.87E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.36|P-value:2.20E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.06|P-value:6.96E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.67|P-value:6.42E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-9.07|P-value:4.52E-21 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.64|P-value:9.43E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.44|P-value:2.11E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.08|P-value:6.52E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.02|P-value:7.95E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.57|P-value:9.52E-5 ID:SGTC_1792|Compound:st045773|FD-Score:-4.02|P-value:1.85E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.08|P-value:6.36E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.02|P-value:9.97E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.16|P-value:6.08E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.13|P-value:5.35E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.24|P-value:4.50E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.81|P-value:4.62E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-5.06|P-value:1.01E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.09|P-value:6.22E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.42|P-value:2.02E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.44|P-value:1.66E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.02|P-value:9.85E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.04|P-value:1.25E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.18|P-value:4.37E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.71|P-value:7.19E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.17|P-value:5.87E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.57|P-value:1.27E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.98|P-value:1.65E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-6.47|P-value:1.37E-11 ID:SGTC_3196|Compound:9111891|FD-Score:-5.88|P-value:7.02E-10 ID:SGTC_3198|Compound:9112019|FD-Score:-3.86|P-value:3.75E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.99|P-value:1.56E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-9.59|P-value:2.46E-23 ID:SGTC_3209|Compound:9113616|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.50|P-value:1.69E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.60|P-value:8.62E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.24|P-value:4.56E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.28|P-value:3.03E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.04|P-value:9.45E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.17|P-value:4.57E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.35|P-value:2.86E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.12|P-value:1.18E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.86|P-value:3.71E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:-3.04|P-value:9.20E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.16|P-value:4.87E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.36|P-value:2.20E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.02|P-value:7.86E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.06|P-value:6.96E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.67|P-value:6.42E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-9.07|P-value:4.52E-21 ID:SGTC_1252|Compound:0493-0875|FD-Score:-3.64|P-value:9.43E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.44|P-value:2.11E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.08|P-value:6.52E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.02|P-value:7.95E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.57|P-value:9.52E-5 ID:SGTC_1792|Compound:st045773|FD-Score:-4.02|P-value:1.85E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.08|P-value:6.36E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.02|P-value:9.97E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.16|P-value:6.08E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.13|P-value:5.35E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.24|P-value:4.50E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.81|P-value:4.62E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-5.06|P-value:1.01E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.09|P-value:6.22E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.42|P-value:2.02E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.44|P-value:1.66E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.02|P-value:9.85E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.04|P-value:1.25E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.18|P-value:4.37E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.71|P-value:7.19E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.17|P-value:5.87E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.57|P-value:1.27E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.98|P-value:1.65E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.01|P-value:8.27E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-6.47|P-value:1.37E-11 ID:SGTC_3196|Compound:9111891|FD-Score:-5.88|P-value:7.02E-10 ID:SGTC_3198|Compound:9112019|FD-Score:-3.86|P-value:3.75E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.99|P-value:1.56E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-9.59|P-value:2.46E-23 ID:SGTC_3209|Compound:9113616|FD-Score:3.48|P-value:1.38E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.50|P-value:1.69E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.60|P-value:8.62E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.24|P-value:4.56E-4

Top fitness defect scores for YBL015W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2487 5918373 4.42 44.0 µM 2.02E-6 6 4.87E-6
2 SGTC_669 0108-0021 4.35 26.2 µM 2.86E-6 fatty acid desaturase (OLE1) 62 6.73E-6
3 SGTC_2602 kawain 4.04 100.0 µM 1.25E-5 23 2.64E-5
4 SGTC_3201 9113999 3.99 49.5 µM 1.56E-5 35 3.26E-5
5 SGTC_2736 butenafine 3.98 14.7 µM 1.65E-5 30 3.44E-5
6 SGTC_1100 amiodarone 3.67 5.1 µM 6.42E-5 22 1.22E-4
7 SGTC_3323 9138564 3.60 53.9 µM 8.62E-5 33 1.60E-4
8 SGTC_1779 st039427 3.57 55.0 µM 9.52E-5 40 1.75E-4
9 SGTC_3209 9113616 3.48 49.5 µM 1.38E-4 46 2.49E-4
10 SGTC_2514 salinomycin 3.44 42.7 µM 1.66E-4 76 2.94E-4
11 SGTC_986 1493-0483 3.36 84.0 µM 2.20E-4 29 3.83E-4
12 SGTC_73 0327-0325 3.28 16.2 µM 3.03E-4 DNA damage response 81 5.16E-4
13 SGTC_2608 thymoquinone 3.18 42.7 µM 4.37E-4 43 7.24E-4
14 SGTC_551 k048-0028 3.17 34.9 µM 4.57E-4 49 7.54E-4
15 SGTC_916 4466-0038 3.16 42.0 nM 4.87E-4 cell wall 124 8.01E-4
16 SGTC_2103 5378138 3.13 10.0 µM 5.35E-4 52 8.74E-4
17 SGTC_2482 5981709 3.09 142.7 µM 6.22E-4 PDR1 83 0.00101
18 SGTC_1793 st048256 3.08 72.2 µM 6.36E-4 18 0.00103
19 SGTC_1315 1237-0019 3.08 3.7 µM 6.52E-4 36 0.00105
20 SGTC_989 1501-0895 3.06 10.3 µM 6.96E-4 26 0.00112

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.344 8.89E-94 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.243 2.55E-46 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.238 2.24E-44 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.235 1.56E-43 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.230 1.90E-41 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.226 2.89E-40 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.222 9.97E-39 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.218 2.13E-37 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.216 1.13E-36 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.216 1.39E-36 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.215 2.49E-36 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.207 8.08E-34 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.203 1.74E-32 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.201 7.60E-32 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.200 9.39E-32 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture