YBL017C / PEP1

Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL017C / PEP1

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-4.11|P-value:1.68E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.80|P-value:7.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.96|P-value:3.73E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.69|P-value:1.33E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.61|P-value:1.97E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.58|P-value:2.62E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.69|P-value:1.28E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.99|P-value:3.30E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.07|P-value:4.81E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.00|P-value:7.51E-9 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.80|P-value:7.72E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.11|P-value:2.21E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.90|P-value:4.73E-4 ID:SGTC_2098|Compound:5376439|FD-Score:2.88|P-value:5.09E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.73|P-value:9.09E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.10|P-value:2.01E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.68|P-value:1.60E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.15|P-value:2.76E-9 ID:SGTC_2316|Compound:5844804|FD-Score:2.97|P-value:3.62E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.52|P-value:3.46E-5 ID:SGTC_2438|Compound:5259590|FD-Score:2.91|P-value:4.51E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.00|P-value:3.52E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.86|P-value:6.26E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.24|P-value:6.85E-7 ID:SGTC_2516|Compound:gossypol|FD-Score:2.75|P-value:8.63E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.93|P-value:4.60E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.52|P-value:3.38E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.74|P-value:1.17E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.25|P-value:1.21E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.21|P-value:1.24E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.21|P-value:1.41E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.97|P-value:3.61E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.11|P-value:1.68E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.80|P-value:7.14E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.96|P-value:3.73E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.69|P-value:1.33E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:3.61|P-value:1.97E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.58|P-value:2.62E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.69|P-value:1.28E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.99|P-value:3.30E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.07|P-value:4.81E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.00|P-value:7.51E-9 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.80|P-value:7.72E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.11|P-value:2.21E-4 ID:SGTC_2014|Compound:4013930|FD-Score:2.90|P-value:4.73E-4 ID:SGTC_2098|Compound:5376439|FD-Score:2.88|P-value:5.09E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.73|P-value:9.09E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.10|P-value:2.01E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.68|P-value:1.60E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-5.15|P-value:2.76E-9 ID:SGTC_2316|Compound:5844804|FD-Score:2.97|P-value:3.62E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.52|P-value:3.46E-5 ID:SGTC_2438|Compound:5259590|FD-Score:2.91|P-value:4.51E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.00|P-value:3.52E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-2.86|P-value:6.26E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.24|P-value:6.85E-7 ID:SGTC_2516|Compound:gossypol|FD-Score:2.75|P-value:8.63E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.93|P-value:4.60E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.52|P-value:3.38E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.74|P-value:1.17E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.25|P-value:1.21E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.21|P-value:1.24E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.21|P-value:1.41E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.97|P-value:3.61E-4

Top fitness defect scores for YBL017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2514 salinomycin 4.24 42.7 µM 6.85E-7 34 1.11E-5
2 SGTC_1212 0520-0165 3.69 585.0 µM 1.28E-5 43 1.10E-4
3 SGTC_457 grayanotoxin iii 3.69 135.0 µM 1.33E-5 87 1.13E-4
4 SGTC_536 3852-0578 3.61 10.6 µM 1.97E-5 40 1.53E-4
5 SGTC_3091 9116372 3.21 49.5 µM 1.24E-4 39 6.53E-4
6 SGTC_2106 5357045 3.10 167.3 µM 2.01E-4 49 9.54E-4
7 SGTC_1282 0886-0010 2.99 32.4 µM 3.30E-4 endomembrane recycling 74 0.00141
8 SGTC_3197 9113331 2.97 49.5 µM 3.61E-4 97 0.00151
9 SGTC_2316 5844804 2.97 197.4 µM 3.62E-4 98 0.00151
10 SGTC_2438 5259590 2.91 200.0 µM 4.51E-4 54 0.00180
11 SGTC_2014 4013930 2.90 200.0 µM 4.73E-4 97 0.00187
12 SGTC_2098 5376439 2.88 882.5 nM 5.09E-4 52 0.00198
13 SGTC_270 tamoxifen 2.80 5.5 µM 7.14E-4 NEO1 101 0.00258
14 SGTC_2516 gossypol 2.75 71.5 µM 8.63E-4 77 0.00300
15 SGTC_2103 5378138 2.73 10.0 µM 9.09E-4 82 0.00312
16 SGTC_411 enrofloxacin 2.69 100.0 µM 0.00107 DNA damage response 59 0.00355
17 SGTC_1309 pyrazolanthrone 2.66 13.4 µM 0.00119 82 0.00385
18 SGTC_2989 9073649 2.58 71.4 µM 0.00160 148 0.00487
19 SGTC_2537 larixol 2.53 68.9 µM 0.00194 132 0.00569
20 SGTC_2894 9048625 2.40 32.5 µM 0.00306 103 0.00815

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.398 1.33E-127 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.328 3.33E-85 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.296 1.14E-68 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.294 8.96E-68 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.289 9.96E-66 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.282 3.97E-62 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.281 9.52E-62 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.270 3.53E-57 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.264 1.50E-54 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.262 1.01E-53 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.255 5.05E-51 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.251 3.29E-49 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.249 3.53E-48 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.247 1.05E-47 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.244 1.34E-46 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth