YBL028C

Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL028C / YBL028C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.36|P-value:2.58E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.82|P-value:2.95E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.88|P-value:1.32E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.39|P-value:6.96E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.48|P-value:5.18E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.49|P-value:5.15E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.47|P-value:6.49E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.83|P-value:2.80E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.86|P-value:1.73E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.27|P-value:3.02E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.85|P-value:1.44E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.67|P-value:3.29E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.94|P-value:1.27E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.86|P-value:1.72E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.43|P-value:6.24E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.32|P-value:8.90E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.54|P-value:5.11E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.17|P-value:5.39E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.67|P-value:3.27E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.45|P-value:5.85E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.86|P-value:1.69E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.36|P-value:9.27E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.98|P-value:1.09E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.35|P-value:9.53E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.94|P-value:1.28E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.36|P-value:2.58E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.82|P-value:2.95E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.88|P-value:1.32E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.39|P-value:6.96E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.48|P-value:5.18E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.49|P-value:5.15E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.47|P-value:6.49E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:-4.83|P-value:2.80E-6 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.86|P-value:1.73E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-4.27|P-value:3.02E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.85|P-value:1.44E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.67|P-value:3.29E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.94|P-value:1.27E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.86|P-value:1.72E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.43|P-value:6.24E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.32|P-value:8.90E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.54|P-value:5.11E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.17|P-value:5.39E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.67|P-value:3.27E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.45|P-value:5.85E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.86|P-value:1.69E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.36|P-value:9.27E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.98|P-value:1.09E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.35|P-value:9.53E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.94|P-value:1.28E-4

Top fitness defect scores for YBL028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 4.36 19.8 µM 2.58E-5 59 6.53E-6
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.17 3.7 µM 5.39E-5 74 1.52E-5
3 SGTC_3316 9136639 3.98 10.6 µM 1.09E-4 13 3.41E-5
4 SGTC_1819 st053448 3.94 58.6 µM 1.27E-4 amide catabolism 20 4.03E-5
5 SGTC_3331 9141060 3.94 2.0 µM 1.28E-4 cell wall 32 4.07E-5
6 SGTC_3302 9125395 3.86 16.4 µM 1.69E-4 12 5.59E-5
7 SGTC_1823 3-hydroxy-2-naphthoic acid 3.86 106.0 µM 1.72E-4 17 5.73E-5
8 SGTC_1049 3226-0134 3.86 66.0 µM 1.73E-4 31 5.77E-5
9 SGTC_2611 pyromycin 3.67 23.9 µM 3.27E-4 36 1.19E-4
10 SGTC_1516 st013856 3.67 110.0 µM 3.29E-4 17 1.20E-4
11 SGTC_2333 9017922 3.54 200.0 µM 5.11E-4 40 1.99E-4
12 SGTC_607 4491-0986 3.47 66.8 µM 6.49E-4 heme requiring 39 2.61E-4
13 SGTC_3312 9133330 3.36 71.4 µM 9.27E-4 16 3.92E-4
14 SGTC_3325 9138760 3.35 55.2 µM 9.53E-4 Golgi 42 4.05E-4
15 SGTC_1775 st081588 3.32 35.2 µM 0.00105 60S ribosome export 46 4.51E-4
16 SGTC_710 3448-4187 3.30 58.0 µM 0.00111 fatty acid desaturase (OLE1) 98 4.82E-4
17 SGTC_972 1319-0219 3.21 195.0 µM 0.00145 59 6.55E-4
18 SGTC_2023 5144124 3.20 124.0 µM 0.00152 49 6.89E-4
19 SGTC_2018 5133068 3.20 143.0 µM 0.00153 57 6.95E-4
20 SGTC_2961 9083290 3.17 32.5 µM 0.00164 41 7.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 7.54E-24 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.167 1.80E-22 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.162 3.43E-21 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.157 4.86E-20 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.152 6.89E-19 YKL215C OXP1 hom 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.151 1.11E-18 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.148 6.24E-18 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.146 2.26E-17 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.145 3.25E-17 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.137 1.49E-15 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.136 2.31E-15 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.132 1.43E-14 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.129 5.43E-14 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.128 8.97E-14 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.127 1.96E-13 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance