YBL029W_p

Non-essential protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL029W / YBL029W

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:3.60|P-value:2.96E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.68|P-value:3.84E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.71|P-value:2.00E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.11|P-value:3.99E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.84|P-value:1.14E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.37|P-value:6.50E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.54|P-value:7.18E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:4.27|P-value:2.28E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.89|P-value:1.01E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.46|P-value:1.03E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.29|P-value:8.55E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.90|P-value:8.80E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.71|P-value:1.96E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.40|P-value:5.90E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.50|P-value:4.13E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.14|P-value:4.57E-7 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.63|P-value:2.69E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.59|P-value:3.01E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.79|P-value:2.41E-6 ID:SGTC_1531|Compound:st059297|FD-Score:-3.62|P-value:2.48E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.68|P-value:2.19E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.37|P-value:6.46E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.26|P-value:9.16E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.27|P-value:8.86E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.58|P-value:2.95E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.93|P-value:7.94E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.97|P-value:7.39E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.33|P-value:6.96E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.73|P-value:1.70E-4 ID:SGTC_2956|Compound:9076196|FD-Score:5.73|P-value:2.14E-8 ID:SGTC_3139|Compound:9095020|FD-Score:-4.53|P-value:6.87E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.63|P-value:4.41E-6 ID:SGTC_3320|Compound:9137005|FD-Score:-4.24|P-value:2.31E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.47|P-value:4.66E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.60|P-value:2.96E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:4.68|P-value:3.84E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.71|P-value:2.00E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-4.11|P-value:3.99E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.84|P-value:1.14E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.37|P-value:6.50E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.54|P-value:7.18E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:4.27|P-value:2.28E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.89|P-value:1.01E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.46|P-value:1.03E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.29|P-value:8.55E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.90|P-value:8.80E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.71|P-value:1.96E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.40|P-value:5.90E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.50|P-value:4.13E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.14|P-value:4.57E-7 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.63|P-value:2.69E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.59|P-value:3.01E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.79|P-value:2.41E-6 ID:SGTC_1531|Compound:st059297|FD-Score:-3.62|P-value:2.48E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.68|P-value:2.19E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.37|P-value:6.46E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.26|P-value:9.16E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.27|P-value:8.86E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.58|P-value:2.95E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.93|P-value:7.94E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.97|P-value:7.39E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.33|P-value:6.96E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.73|P-value:1.70E-4 ID:SGTC_2956|Compound:9076196|FD-Score:5.73|P-value:2.14E-8 ID:SGTC_3139|Compound:9095020|FD-Score:-4.53|P-value:6.87E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-4.63|P-value:4.41E-6 ID:SGTC_3320|Compound:9137005|FD-Score:-4.24|P-value:2.31E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.47|P-value:4.66E-4

Top fitness defect scores for YBL029W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2956 9076196 5.73 2.5 µM 2.14E-8 3 4.98E-9
2 SGTC_1381 2324-0066 5.14 62.1 µM 4.57E-7 11 1.40E-7
3 SGTC_1526 st051518 4.79 75.0 µM 2.41E-6 10 8.54E-7
4 SGTC_144 4161-2749 4.68 112.4 µM 3.84E-6 DNA intercalators 16 1.42E-6
5 SGTC_245 methotrexate 4.54 289.6 µM 7.18E-6 29 2.80E-6
6 SGTC_1017 4239-0030 4.46 168.0 µM 1.03E-5 16 4.17E-6
7 SGTC_970 1315-0089 4.27 19.5 µM 2.28E-5 RSC & ERG11 18 9.85E-6
8 SGTC_2404 5161160 3.97 200.0 µM 7.39E-5 19 3.55E-5
9 SGTC_1013 4112-3890 3.89 241.0 µM 1.01E-4 TSC3-RPN4 33 5.00E-5
10 SGTC_1246 0422-0085 3.71 105.0 µM 1.96E-4 41 1.02E-4
11 SGTC_145 3737-0113 3.71 38.4 µM 2.00E-4 DNA intercalators 85 1.05E-4
12 SGTC_1752 st044819 3.68 83.0 µM 2.19E-4 31 1.16E-4
13 SGTC_1817 st052116 3.64 64.4 µM 2.55E-4 RNA processing & uracil transport 18 1.37E-4
14 SGTC_1392 3455-1037 3.63 33.9 µM 2.69E-4 23 1.44E-4
15 SGTC_131 0141-0277 3.60 33.9 µM 2.96E-4 51 1.60E-4
16 SGTC_1448 4255-0083 3.59 152.0 µM 3.01E-4 ERG2 27 1.63E-4
17 SGTC_1249 0481-0015 3.50 10.2 µM 4.13E-4 39 2.30E-4
18 SGTC_3325 9138760 3.47 55.2 µM 4.66E-4 Golgi 38 2.63E-4
19 SGTC_1247 0448-0043 3.40 5.8 µM 5.90E-4 ERG2 77 3.39E-4
20 SGTC_2016 5121758 3.37 140.0 µM 6.46E-4 redox potentiating 81 3.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 2.88E-17 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.136 3.20E-15 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.129 5.58E-14 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 6.87E-12 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.115 3.01E-11 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.114 3.58E-11 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 3.92E-11 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.114 3.95E-11 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.114 4.21E-11 YOL098C_p YOL098C_p hom Putative metalloprotease
0.113 6.57E-11 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.106 7.71E-10 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.105 1.17E-9 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.103 1.89E-9 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.100 5.89E-9 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.100 6.77E-9 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p