YBL034C / STU1

Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL034C / STU1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.95|P-value:2.38E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.31|P-value:2.89E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.57|P-value:6.02E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.70|P-value:8.86E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-2.82|P-value:5.37E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.70|P-value:8.65E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.03|P-value:2.26E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.33|P-value:3.35E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:12.90|P-value:5.04E-51 ID:SGTC_163|Compound:1327-0036|FD-Score:12.00|P-value:2.62E-44 ID:SGTC_212|Compound:3807-4682|FD-Score:24.80|P-value:4.78E-182 ID:SGTC_229|Compound:benomyl|FD-Score:2.78|P-value:6.24E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.03|P-value:2.26E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.32|P-value:6.06E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.12|P-value:1.50E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.71|P-value:8.57E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.40|P-value:4.05E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:15.00|P-value:4.12E-68 ID:SGTC_429|Compound:1112-0049|FD-Score:5.14|P-value:1.21E-9 ID:SGTC_632|Compound:0781-2353|FD-Score:2.76|P-value:6.63E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.66|P-value:1.09E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.31|P-value:5.97E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:-2.93|P-value:3.43E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-2.74|P-value:7.44E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.57|P-value:1.69E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-2.79|P-value:6.05E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.45|P-value:3.19E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.02|P-value:2.26E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.82|P-value:5.54E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.79|P-value:5.97E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.83|P-value:5.14E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.91|P-value:3.57E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.48|P-value:2.78E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-2.88|P-value:4.21E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.22|P-value:9.20E-5 ID:SGTC_1959|Compound:st077091|FD-Score:2.72|P-value:7.80E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.03|P-value:2.25E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-2.98|P-value:2.83E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.39|P-value:4.25E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.69|P-value:9.42E-6 ID:SGTC_2248|Compound:tofa|FD-Score:3.68|P-value:9.69E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.73|P-value:1.96E-8 ID:SGTC_2259|Compound:7964009|FD-Score:-3.15|P-value:1.30E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-2.88|P-value:4.24E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.20|P-value:1.05E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.96|P-value:2.99E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-2.79|P-value:6.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.80|P-value:5.64E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.59|P-value:1.57E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.77|P-value:6.35E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.29|P-value:1.46E-13 ID:SGTC_2692|Compound:st077426|FD-Score:5.45|P-value:1.30E-10 ID:SGTC_2805|Compound:7950783|FD-Score:-3.52|P-value:2.30E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.03|P-value:1.49E-6 ID:SGTC_2990|Compound:9074105|FD-Score:-3.74|P-value:7.36E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.50|P-value:2.46E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-2.89|P-value:4.03E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.95|P-value:2.38E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.31|P-value:2.89E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.57|P-value:6.02E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:-2.70|P-value:8.86E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-2.82|P-value:5.37E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.70|P-value:8.65E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.03|P-value:2.26E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.33|P-value:3.35E-10 ID:SGTC_149|Compound:3970-0822|FD-Score:12.90|P-value:5.04E-51 ID:SGTC_163|Compound:1327-0036|FD-Score:12.00|P-value:2.62E-44 ID:SGTC_212|Compound:3807-4682|FD-Score:24.80|P-value:4.78E-182 ID:SGTC_229|Compound:benomyl|FD-Score:2.78|P-value:6.24E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.03|P-value:2.26E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.32|P-value:6.06E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.12|P-value:1.50E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.71|P-value:8.57E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.40|P-value:4.05E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:15.00|P-value:4.12E-68 ID:SGTC_429|Compound:1112-0049|FD-Score:5.14|P-value:1.21E-9 ID:SGTC_632|Compound:0781-2353|FD-Score:2.76|P-value:6.63E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.66|P-value:1.09E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.31|P-value:5.97E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:-2.93|P-value:3.43E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-2.74|P-value:7.44E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.57|P-value:1.69E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-2.79|P-value:6.05E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.45|P-value:3.19E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.02|P-value:2.26E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-2.82|P-value:5.54E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.79|P-value:5.97E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.83|P-value:5.14E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:2.91|P-value:3.57E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.48|P-value:2.78E-5 ID:SGTC_1850|Compound:st056238|FD-Score:-2.88|P-value:4.21E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.22|P-value:9.20E-5 ID:SGTC_1959|Compound:st077091|FD-Score:2.72|P-value:7.80E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.03|P-value:2.25E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-2.98|P-value:2.83E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.39|P-value:4.25E-5 ID:SGTC_2242|Compound:6630449|FD-Score:-3.69|P-value:9.42E-6 ID:SGTC_2248|Compound:tofa|FD-Score:3.68|P-value:9.69E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.73|P-value:1.96E-8 ID:SGTC_2259|Compound:7964009|FD-Score:-3.15|P-value:1.30E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-2.88|P-value:4.24E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.20|P-value:1.05E-4 ID:SGTC_2354|Compound:9060492|FD-Score:2.96|P-value:2.99E-4 ID:SGTC_2373|Compound:9071805|FD-Score:-2.79|P-value:6.07E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.80|P-value:5.64E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.59|P-value:1.57E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.77|P-value:6.35E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.29|P-value:1.46E-13 ID:SGTC_2692|Compound:st077426|FD-Score:5.45|P-value:1.30E-10 ID:SGTC_2805|Compound:7950783|FD-Score:-3.52|P-value:2.30E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.03|P-value:1.49E-6 ID:SGTC_2990|Compound:9074105|FD-Score:-3.74|P-value:7.36E-6 ID:SGTC_2994|Compound:9053520|FD-Score:3.50|P-value:2.46E-5 ID:SGTC_3003|Compound:9075612|FD-Score:-2.89|P-value:4.03E-4

Top fitness defect scores for YBL034C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_212 3807-4682 24.80 38.8 µM 4.78E-182 tubulin folding & SWR complex 1 6.11E-136 14.70
2 SGTC_379 3970-0972 15.00 5.9 µM 4.12E-68 tubulin folding & SWR complex 1 3.59E-51 9.19
3 SGTC_149 3970-0822 12.90 46.1 µM 5.04E-51 tubulin folding & SWR complex 1 1.89E-38 6.61
4 SGTC_163 1327-0036 12.00 7.5 µM 2.62E-44 9 1.89E-33 0.33
5 SGTC_2651 1327-0036 6.29 5.0 µM 1.46E-13 30 1.59E-10 0.04
6 SGTC_2692 st077426 5.45 47.7 µM 1.30E-10 1 2.55E-8 0.63
7 SGTC_429 1112-0049 5.14 25.5 µM 1.21E-9 DNA damage response 3 1.36E-7 0.29
8 SGTC_2254 7938975 4.73 95.2 µM 1.96E-8 5 1.10E-6 0.45
9 SGTC_70 0141-0289 3.70 43.3 µM 8.65E-6 mitochondrial stress 22 1.07E-4 0.04
10 SGTC_2248 tofa 3.68 1.1 µM 9.69E-6 sphingolipid biosynthesis & PDR1 33 1.16E-4 1.95E-4
11 SGTC_682 0kpi-0099 3.66 17.0 µM 1.09E-5 35 1.27E-4 0.03
12 SGTC_763 3453-1109 3.57 128.0 µM 1.69E-5 9 1.77E-4 0.16
13 SGTC_2994 9053520 3.50 71.4 µM 2.46E-5 RPP1 & pyrimidine depletion 14 2.35E-4 0.17
14 SGTC_375 3970-0961 3.40 9.3 µM 4.05E-5 tubulin folding & SWR complex 15 3.42E-4 0.08
15 SGTC_2238 6671620 3.39 73.2 µM 4.25E-5 7 3.55E-4 0.07
16 SGTC_701 4424-0219 3.31 185.0 µM 5.97E-5 calcium & mitochondrial duress 5 4.60E-4 0.15
17 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.22 14.9 µM 9.20E-5 14 6.37E-4 0.01
18 SGTC_1090 efavirenz 3.02 20.7 µM 2.26E-4 11 0.00126 0.03
19 SGTC_2354 9060492 2.96 162.0 µM 2.99E-4 16 0.00155 0.25
20 SGTC_1472 k841-0093 2.91 193.0 µM 3.57E-4 12 0.00178 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.381 4.40E-116 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.327 2.74E-84 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.240 4.53E-45 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.236 1.26E-43 YDL146W LDB17 hom Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.233 1.92E-42 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.231 7.34E-42 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.228 1.11E-40 YBR216C YBP1 hom Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication
0.216 6.77E-37 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.213 1.15E-35 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.206 1.38E-33 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.194 6.45E-30 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.190 1.08E-28 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.190 1.30E-28 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.185 3.44E-27 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.184 4.90E-27 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin