HIPHOP chemogenomics database

YBL043W / ECM13

Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YBL043W / ECM13

Click on Significant Values for Screen Details

Top fitness defect scores for YBL043W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1203	3992-3522	3.86	103.0 µM	3.72E-6		38	5.66E-5
2	SGTC_1262	0737-0114	3.67	49.6 µM	1.01E-5		24	1.21E-4
3	SGTC_968	1309-0633	3.64	340.0 µM	1.17E-5		20	1.35E-4
4	SGTC_2046	4110841	3.61	106.0 µM	1.40E-5	iron homeostasis	35	1.54E-4
5	SGTC_1219	1469-0211	3.57	33.1 µM	1.67E-5		22	1.76E-4
6	SGTC_2491	paeonol	3.55	100.0 µM	1.88E-5		12	1.93E-4
7	SGTC_2533	agelasine	3.55	13.7 µM	1.91E-5	ERG2	62	1.96E-4
8	SGTC_2625	euphol	3.53	100.0 µM	2.03E-5		39	2.05E-4
9	SGTC_1725	st036284	3.53	20.6 µM	2.10E-5		46	2.10E-4
10	SGTC_1636	st007707	3.33	68.9 µM	5.51E-5		71	4.37E-4
11	SGTC_65	0798-0905	3.11	35.0 µM	1.52E-4	calcium & mitochondrial duress	153	9.43E-4
12	SGTC_1009	4106-0057	3.00	9.9 µM	2.45E-4		44	0.00135
13	SGTC_716	1683-5115	2.99	658.0 µM	2.54E-4		66	0.00140
14	SGTC_279	1273-0055	2.97	2.9 µM	2.77E-4	azole & statin	87	0.00149
15	SGTC_2620	irigenin	2.94	100.0 µM	3.13E-4		89	0.00163
16	SGTC_1008	4106-0037	2.90	6.0 µM	3.80E-4	PDR1	55	0.00189
17	SGTC_358	0075-0058	2.58	9.4 µM	0.00133		194	0.00493
18	SGTC_2490	carminic acid	2.55	95.4 µM	0.00152		55	0.00544
19	SGTC_2421	5690543	2.51	90.7 µM	0.00173		111	0.00602
20	SGTC_164	4100-3994	2.47	89.6 µM	0.00200		155	0.00674

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.207	9.87E-34	YLR189C	ATG26	hom	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.187	1.00E-27	YLR199C	PBA1	hom	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.181	5.43E-26	YBR115C	LYS2	hom	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.164	1.61E-21	YDR193W_d	YDR193W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.164	1.47E-21	YOR268C_p	YOR268C_p	hom	Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.161	8.19E-21	YNR039C	ZRG17	hom	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.158	3.36E-20	YDL121C_p	YDL121C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.158	4.69E-20	YGR001C_p	YGR001C_p	hom	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.148	5.55E-18	YNL086W_p	SNN1_p	hom	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.147	1.29E-17	YHL016C	DUR3	hom	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.144	4.98E-17	YIL010W	DOT5	hom	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.143	1.05E-16	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.142	1.40E-16	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.139	7.08E-16	YOR062C_p	YOR062C_p	hom	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.134	5.65E-15	YML116W	ATR1	hom	Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress