YBL043W / ECM13

Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL043W / ECM13

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.11|P-value:1.52E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-2.78|P-value:7.40E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:2.97|P-value:2.77E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.08|P-value:2.10E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.90|P-value:4.57E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.01|P-value:2.85E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.99|P-value:2.54E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.07|P-value:2.23E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.64|P-value:1.17E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.90|P-value:3.80E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.00|P-value:2.45E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.86|P-value:3.72E-6 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.57|P-value:1.67E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.67|P-value:1.01E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.33|P-value:5.51E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.92|P-value:4.22E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.53|P-value:2.10E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.61|P-value:1.40E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.06|P-value:2.27E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.55|P-value:1.88E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.55|P-value:1.91E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.84|P-value:5.85E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.94|P-value:3.13E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.53|P-value:2.03E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-2.89|P-value:4.72E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.00|P-value:2.93E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.08|P-value:2.14E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-4.28|P-value:4.44E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-5.19|P-value:1.25E-9 ID:SGTC_3301|Compound:9125354|FD-Score:-2.72|P-value:9.36E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-2.89|P-value:4.63E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.11|P-value:1.52E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-2.78|P-value:7.40E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:2.97|P-value:2.77E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.08|P-value:2.10E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.90|P-value:4.57E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.01|P-value:2.85E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:2.99|P-value:2.54E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.07|P-value:2.23E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.64|P-value:1.17E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.90|P-value:3.80E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.00|P-value:2.45E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.86|P-value:3.72E-6 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.57|P-value:1.67E-5 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.67|P-value:1.01E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.33|P-value:5.51E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.92|P-value:4.22E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.53|P-value:2.10E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.61|P-value:1.40E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.06|P-value:2.27E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:3.55|P-value:1.88E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.55|P-value:1.91E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.84|P-value:5.85E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:2.94|P-value:3.13E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.53|P-value:2.03E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-2.89|P-value:4.72E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.00|P-value:2.93E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.08|P-value:2.14E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-4.28|P-value:4.44E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-5.19|P-value:1.25E-9 ID:SGTC_3301|Compound:9125354|FD-Score:-2.72|P-value:9.36E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-2.89|P-value:4.63E-4

Top fitness defect scores for YBL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1203 3992-3522 3.86 103.0 µM 3.72E-6 38 5.66E-5
2 SGTC_1262 0737-0114 3.67 49.6 µM 1.01E-5 24 1.21E-4
3 SGTC_968 1309-0633 3.64 340.0 µM 1.17E-5 20 1.35E-4
4 SGTC_2046 4110841 3.61 106.0 µM 1.40E-5 iron homeostasis 35 1.54E-4
5 SGTC_1219 1469-0211 3.57 33.1 µM 1.67E-5 22 1.76E-4
6 SGTC_2491 paeonol 3.55 100.0 µM 1.88E-5 12 1.93E-4
7 SGTC_2533 agelasine 3.55 13.7 µM 1.91E-5 ERG2 62 1.96E-4
8 SGTC_2625 euphol 3.53 100.0 µM 2.03E-5 39 2.05E-4
9 SGTC_1725 st036284 3.53 20.6 µM 2.10E-5 46 2.10E-4
10 SGTC_1636 st007707 3.33 68.9 µM 5.51E-5 71 4.37E-4
11 SGTC_65 0798-0905 3.11 35.0 µM 1.52E-4 calcium & mitochondrial duress 153 9.43E-4
12 SGTC_1009 4106-0057 3.00 9.9 µM 2.45E-4 44 0.00135
13 SGTC_716 1683-5115 2.99 658.0 µM 2.54E-4 66 0.00140
14 SGTC_279 1273-0055 2.97 2.9 µM 2.77E-4 azole & statin 87 0.00149
15 SGTC_2620 irigenin 2.94 100.0 µM 3.13E-4 89 0.00163
16 SGTC_1008 4106-0037 2.90 6.0 µM 3.80E-4 PDR1 55 0.00189
17 SGTC_358 0075-0058 2.58 9.4 µM 0.00133 194 0.00493
18 SGTC_2490 carminic acid 2.55 95.4 µM 0.00152 55 0.00544
19 SGTC_2421 5690543 2.51 90.7 µM 0.00173 111 0.00602
20 SGTC_164 4100-3994 2.47 89.6 µM 0.00200 155 0.00674

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 9.87E-34 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.187 1.00E-27 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.181 5.43E-26 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.164 1.61E-21 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.164 1.47E-21 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.161 8.19E-21 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.158 3.36E-20 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.158 4.69E-20 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.148 5.55E-18 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.147 1.29E-17 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.144 4.98E-17 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.143 1.05E-16 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.142 1.40E-16 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.139 7.08E-16 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.134 5.65E-15 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress