HIPHOP chemogenomics database

YBL058W / SHP1

UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate

Zygosity: Homozygous strain

fixedexpanded
Profile for YBL058W / SHP1

Click on Significant Values for Screen Details

Top fitness defect scores for YBL058W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3136	9095672	4.42	49.5 µM	7.61E-6		14	5.00E-6
2	SGTC_3137	9097352	4.41	49.5 µM	7.98E-6		29	5.26E-6
3	SGTC_2399	5884133	4.14	200.0 µM	2.39E-5	cell wall signaling	65	1.72E-5
4	SGTC_2962	9082311	4.06	13.2 µM	3.26E-5		20	2.41E-5
5	SGTC_1944	st076371	4.02	56.9 µM	3.96E-5		19	2.97E-5
6	SGTC_1766	st045414	3.94	44.8 µM	5.30E-5	RPP1 & pyrimidine depletion	27	4.06E-5
7	SGTC_45	0kpi-0036	3.73	14.9 µM	1.17E-4	excess fatty acid	34	9.53E-5
8	SGTC_2333	9017922	3.69	200.0 µM	1.34E-4		34	1.10E-4
9	SGTC_2279	7948423	3.64	32.9 µM	1.66E-4		20	1.38E-4
10	SGTC_2334	9017922	3.62	200.0 µM	1.74E-4		35	1.46E-4
11	SGTC_3027	9089541	3.56	49.5 µM	2.16E-4	fatty acid desaturase (OLE1)	33	1.84E-4
12	SGTC_43	0570-0105	3.45	72.5 µM	3.17E-4	ERG2	138	2.78E-4
13	SGTC_2950	9072895	3.42	21.5 µM	3.61E-4		66	3.19E-4
14	SGTC_2643	anethole	3.23	100.0 µM	6.81E-4		41	6.28E-4
15	SGTC_1684	st024538	3.19	14.6 µM	7.55E-4		28	7.02E-4
16	SGTC_2524	avocatin b	3.10	10.6 µM	0.00102		48	9.71E-4
17	SGTC_1526	st051518	3.04	75.0 µM	0.00122		53	0.00117
18	SGTC_2270	7924575	2.93	90.9 µM	0.00173	RPP1 & pyrimidine depletion	66	0.00169
19	SGTC_3217	9129673	2.90	49.5 µM	0.00190		104	0.00188
20	SGTC_1428	4049-0204	2.88	61.7 µM	0.00200		61	0.00198

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.118	6.14E-12	YJL175W_d	YJL175W_d	hom	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.092	1.01E-7	YJL115W	ASF1	hom	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
0.090	1.85E-7	YDR379W	RGA2	hom	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.086	7.12E-7	YLR231C	BNA5	hom	Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.085	8.34E-7	YGL089C	MF(ALPHA)2	hom	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.084	1.11E-6	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081	2.81E-6	YPR161C	SGV1	het	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
0.077	8.61E-6	YNR030W	ALG12	hom	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.077	8.35E-6	YBL003C	HTA2	hom	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.075	1.37E-5	YFL034C-B	MOB2	het	Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.075	1.50E-5	YKL053C-A	MDM35	hom	Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.072	2.78E-5	YPR026W	ATH1	hom	Acid trehalase required for utilization of extracellular trehalose
0.072	2.97E-5	YLR284C	ECI1	hom	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
0.072	2.98E-5	YBR260C	RGD1	hom	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.071	4.08E-5	YGL181W	GTS1	hom	Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations