YBL058W / SHP1

UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL058W / SHP1

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.72|P-value:4.16E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.45|P-value:3.17E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.51|P-value:8.26E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.58|P-value:6.71E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-3.56|P-value:6.97E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.39|P-value:3.51E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.83|P-value:2.82E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-4.87|P-value:4.68E-6 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.57|P-value:6.74E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:-3.51|P-value:8.35E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.94|P-value:5.30E-5 ID:SGTC_1927|Compound:st060202|FD-Score:-3.96|P-value:1.79E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.02|P-value:3.96E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-3.54|P-value:7.41E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.91|P-value:2.11E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.49|P-value:2.32E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.64|P-value:1.66E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-4.66|P-value:1.20E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.69|P-value:1.34E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.62|P-value:1.74E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.68|P-value:4.77E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-4.08|P-value:1.17E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.95|P-value:1.86E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.14|P-value:2.39E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-3.53|P-value:7.70E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.48|P-value:9.27E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.23|P-value:6.81E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.98|P-value:1.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.71|P-value:4.32E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.42|P-value:3.61E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.99|P-value:2.80E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-3.64|P-value:5.43E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.06|P-value:3.26E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.56|P-value:2.16E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.42|P-value:7.61E-6 ID:SGTC_3137|Compound:9097352|FD-Score:4.41|P-value:7.98E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-6.13|P-value:9.88E-9 ID:SGTC_3203|Compound:9113543|FD-Score:-5.28|P-value:7.46E-7 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.72|P-value:4.16E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.45|P-value:3.17E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.51|P-value:8.26E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.58|P-value:6.71E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-3.56|P-value:6.97E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-4.39|P-value:3.51E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.83|P-value:2.82E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-4.87|P-value:4.68E-6 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.57|P-value:6.74E-4 ID:SGTC_1553|Compound:gossypol|FD-Score:-3.51|P-value:8.35E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.19|P-value:7.55E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.94|P-value:5.30E-5 ID:SGTC_1927|Compound:st060202|FD-Score:-3.96|P-value:1.79E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.02|P-value:3.96E-5 ID:SGTC_2198|Compound:6589944|FD-Score:-3.54|P-value:7.41E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.91|P-value:2.11E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.49|P-value:2.32E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.64|P-value:1.66E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-4.66|P-value:1.20E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.69|P-value:1.34E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.62|P-value:1.74E-4 ID:SGTC_2369|Compound:9071472|FD-Score:-3.68|P-value:4.77E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-4.08|P-value:1.17E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.95|P-value:1.86E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.14|P-value:2.39E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-3.53|P-value:7.70E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.48|P-value:9.27E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.23|P-value:6.81E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.98|P-value:1.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.71|P-value:4.32E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.42|P-value:3.61E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-4.99|P-value:2.80E-6 ID:SGTC_2960|Compound:9079389|FD-Score:-3.64|P-value:5.43E-4 ID:SGTC_2962|Compound:9082311|FD-Score:4.06|P-value:3.26E-5 ID:SGTC_3027|Compound:9089541|FD-Score:3.56|P-value:2.16E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.42|P-value:7.61E-6 ID:SGTC_3137|Compound:9097352|FD-Score:4.41|P-value:7.98E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-6.13|P-value:9.88E-9 ID:SGTC_3203|Compound:9113543|FD-Score:-5.28|P-value:7.46E-7

Top fitness defect scores for YBL058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3136 9095672 4.42 49.5 µM 7.61E-6 14 5.00E-6
2 SGTC_3137 9097352 4.41 49.5 µM 7.98E-6 29 5.26E-6
3 SGTC_2399 5884133 4.14 200.0 µM 2.39E-5 cell wall signaling 65 1.72E-5
4 SGTC_2962 9082311 4.06 13.2 µM 3.26E-5 20 2.41E-5
5 SGTC_1944 st076371 4.02 56.9 µM 3.96E-5 19 2.97E-5
6 SGTC_1766 st045414 3.94 44.8 µM 5.30E-5 RPP1 & pyrimidine depletion 27 4.06E-5
7 SGTC_45 0kpi-0036 3.73 14.9 µM 1.17E-4 excess fatty acid 34 9.53E-5
8 SGTC_2333 9017922 3.69 200.0 µM 1.34E-4 34 1.10E-4
9 SGTC_2279 7948423 3.64 32.9 µM 1.66E-4 20 1.38E-4
10 SGTC_2334 9017922 3.62 200.0 µM 1.74E-4 35 1.46E-4
11 SGTC_3027 9089541 3.56 49.5 µM 2.16E-4 fatty acid desaturase (OLE1) 33 1.84E-4
12 SGTC_43 0570-0105 3.45 72.5 µM 3.17E-4 ERG2 138 2.78E-4
13 SGTC_2950 9072895 3.42 21.5 µM 3.61E-4 66 3.19E-4
14 SGTC_2643 anethole 3.23 100.0 µM 6.81E-4 41 6.28E-4
15 SGTC_1684 st024538 3.19 14.6 µM 7.55E-4 28 7.02E-4
16 SGTC_2524 avocatin b 3.10 10.6 µM 0.00102 48 9.71E-4
17 SGTC_1526 st051518 3.04 75.0 µM 0.00122 53 0.00117
18 SGTC_2270 7924575 2.93 90.9 µM 0.00173 RPP1 & pyrimidine depletion 66 0.00169
19 SGTC_3217 9129673 2.90 49.5 µM 0.00190 104 0.00188
20 SGTC_1428 4049-0204 2.88 61.7 µM 0.00200 61 0.00198

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.14E-12 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.092 1.01E-7 YJL115W ASF1 hom Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
0.090 1.85E-7 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.086 7.12E-7 YLR231C BNA5 hom Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.085 8.34E-7 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.084 1.11E-6 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.81E-6 YPR161C SGV1 het Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
0.077 8.61E-6 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.077 8.35E-6 YBL003C HTA2 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.075 1.37E-5 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.075 1.50E-5 YKL053C-A MDM35 hom Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.072 2.78E-5 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.072 2.97E-5 YLR284C ECI1 hom Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
0.072 2.98E-5 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.071 4.08E-5 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations