HIPHOP chemogenomics database
YBL063W / KIP1 
Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YBL063W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.171 | 1.60E-23 | YDR411C | DFM1 | hom | Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p |
| 0.165 | 8.41E-22 | YBL055C | YBL055C | hom | 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases |
| 0.162 | 3.07E-21 | YBR085W | AAC3 | hom | Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication |
| 0.161 | 6.62E-21 | YOR012W_p | YOR012W_p | hom | Putative protein of unknown function |
| 0.160 | 1.08E-20 | YDR499W | LCD1 | het | Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress |
| 0.158 | 2.66E-20 | YDR122W | KIN1 | hom | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p |
| 0.153 | 5.69E-19 | YGR097W | ASK10 | hom | Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication |
| 0.152 | 1.06E-18 | YER064C | VHR2 | hom | Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
| 0.148 | 6.63E-18 | YDR299W | BFR2 | het | Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock |
| 0.147 | 1.13E-17 | YBR070C | ALG14 | het | Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases |
| 0.143 | 9.59E-17 | YBL044W_p | YBL044W_p | hom | Putative protein of unknown function; YBL044W is not an essential protein |
| 0.141 | 2.50E-16 | YCR088W | ABP1 | hom | Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences |
| 0.140 | 3.06E-16 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |
| 0.139 | 5.33E-16 | YMR150C | IMP1 | hom | Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p |
| 0.134 | 5.82E-15 | YML074C | FPR3 | hom | Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p |