HIPHOP chemogenomics database

YBL071C-B_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain

fixedexpanded
Profile for YBL071C-B / YBL071C-B

Click on Significant Values for Screen Details

Top fitness defect scores for YBL071C-B deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2125	5246583	5.86	200.0 µM	1.70E-8	tubulin folding & SWR complex	17	2.31E-9
2	SGTC_450	aminopyrene	5.61	156.0 nM	6.22E-8		10	9.93E-9
3	SGTC_1920	st075728	5.49	45.7 µM	1.20E-7		2	2.07E-8
4	SGTC_1249	0481-0015	5.44	10.2 µM	1.50E-7		10	2.66E-8
5	SGTC_1728	st035614	5.05	33.8 µM	9.77E-7		20	2.18E-7
6	SGTC_118	0083-0097	5.04	135.3 µM	1.05E-6	translation	57	2.35E-7
7	SGTC_2802	7925815	4.95	54.5 µM	1.58E-6		18	3.72E-7
8	SGTC_2688	kanamycin b	4.94	96.7 µM	1.62E-6	calcium & mitochondrial duress	249	3.84E-7
9	SGTC_1056	3448-1962	4.94	115.0 µM	1.67E-6	amide catabolism	11	3.96E-7
10	SGTC_1781	st038725	4.61	66.3 µM	6.98E-6	NEO1	82	1.97E-6
11	SGTC_800	3448-7362	4.58	155.0 µM	7.92E-6	translation	112	2.27E-6
12	SGTC_991	3996-0057	4.55	64.7 µM	9.05E-6		10	2.64E-6
13	SGTC_1998	st075797	4.40	76.8 µM	1.70E-5	mitochondrial response to ROS	10	5.34E-6
14	SGTC_1252	0493-0875	4.36	34.8 µM	2.01E-5		18	6.44E-6
15	SGTC_2679	rapamycin	4.18	1.0 nM	4.13E-5		128	1.44E-5
16	SGTC_408	cantharidin	4.10	100.0 µM	5.69E-5	cell wall signaling	19	2.07E-5
17	SGTC_2832	7992762	4.04	52.0 µM	7.15E-5		28	2.67E-5
18	SGTC_2288	7946289	3.98	167.3 µM	8.82E-5		25	3.37E-5
19	SGTC_176	1486-1328	3.96	72.8 µM	9.54E-5		51	3.68E-5
20	SGTC_2834	9001755	3.89	58.4 µM	1.25E-4		37	4.98E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.213	8.85E-36	YGR162W	TIF4631	hom	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.176	1.19E-24	YJL136C	RPS21B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.161	7.14E-21	YLR264C-A_p	YLR264C-A_p	hom	Putative protein of unknown function
0.155	1.37E-19	YLR048W	RPS0B	hom	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.139	5.46E-16	YLR264W	RPS28B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.132	1.55E-14	YLR061W	RPL22A	hom	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.131	2.91E-14	YJL189W	RPL39	hom	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.124	4.73E-13	YPL101W	ELP4	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.124	5.49E-13	YDR241W_d	BUD26_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.124	5.84E-13	YFR032C-B_p	YFR032C-B_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.123	1.01E-12	YBR191W	RPL21A	hom	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.121	2.16E-12	YGR118W	RPS23A	hom	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.119	5.73E-12	YOR293W	RPS10A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.117	9.64E-12	YJL188C_d	BUD19_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.113	5.44E-11	YOL040C	RPS15	het	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19