YBL079W / NUP170

Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL079W / NUP170

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.67|P-value:5.01E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.24|P-value:7.15E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.09|P-value:1.32E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:5.80|P-value:1.00E-7 ID:SGTC_56|Compound:0957-0365|FD-Score:4.07|P-value:1.33E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:7.56|P-value:6.61E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:3.58|P-value:6.58E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.73|P-value:4.09E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.20|P-value:5.80E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:4.90|P-value:5.58E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:5.21|P-value:1.50E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.79|P-value:3.66E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.95|P-value:2.01E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.59|P-value:6.41E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.64|P-value:5.50E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.38|P-value:4.31E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.63|P-value:2.52E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.53|P-value:1.27E-14 ID:SGTC_315|Compound:k915-0449|FD-Score:4.31|P-value:5.49E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.76|P-value:3.72E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.56|P-value:7.02E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.53|P-value:3.69E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:8.35|P-value:3.87E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:5.84|P-value:8.40E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:6.66|P-value:1.25E-9 ID:SGTC_533|Compound:1222-0222|FD-Score:3.78|P-value:3.49E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.30|P-value:1.01E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.76|P-value:1.02E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.95|P-value:4.63E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:5.42|P-value:5.92E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.22|P-value:7.70E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:6.60|P-value:1.74E-9 ID:SGTC_895|Compound:0964-0006|FD-Score:3.90|P-value:2.37E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.53|P-value:7.64E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:6.05|P-value:2.94E-8 ID:SGTC_994|Compound:3910-0338|FD-Score:4.49|P-value:2.86E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.39|P-value:6.95E-7 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.75|P-value:4.21E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.10|P-value:1.18E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.38|P-value:7.31E-7 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.51|P-value:2.68E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.63|P-value:5.61E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.90|P-value:2.35E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.39|P-value:6.74E-7 ID:SGTC_1304|Compound:1165-0502|FD-Score:11.40|P-value:9.48E-25 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.79|P-value:3.42E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.71|P-value:2.52E-12 ID:SGTC_1641|Compound:st009299|FD-Score:3.63|P-value:5.71E-4 ID:SGTC_1687|Compound:st020778|FD-Score:7.40|P-value:1.70E-11 ID:SGTC_1694|Compound:st024011|FD-Score:4.85|P-value:6.78E-6 ID:SGTC_1700|Compound:st030840|FD-Score:5.43|P-value:5.70E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.53|P-value:2.65E-5 ID:SGTC_1750|Compound:st081859|FD-Score:9.19|P-value:9.92E-17 ID:SGTC_1803|Compound:st050068|FD-Score:3.98|P-value:1.81E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.61|P-value:6.01E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:15.10|P-value:9.97E-42 ID:SGTC_1941|Compound:st076221|FD-Score:7.72|P-value:2.37E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.83|P-value:3.21E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.65|P-value:5.33E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.67|P-value:5.06E-4 ID:SGTC_2077|Compound:5212015|FD-Score:6.42|P-value:4.57E-9 ID:SGTC_2084|Compound:5306078|FD-Score:3.95|P-value:1.98E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.64|P-value:5.90E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.71|P-value:4.36E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.30|P-value:4.29E-17 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.83|P-value:7.65E-6 ID:SGTC_2421|Compound:5690543|FD-Score:3.63|P-value:5.60E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.06|P-value:1.37E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.45|P-value:5.19E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.53|P-value:7.66E-4 ID:SGTC_2526|Compound:patulin|FD-Score:7.60|P-value:4.95E-12 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.11|P-value:2.55E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.90|P-value:2.51E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.91|P-value:2.28E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:15.00|P-value:2.80E-41 ID:SGTC_2692|Compound:st077426|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.88|P-value:3.55E-10 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.92|P-value:2.41E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.75|P-value:3.81E-4 ID:SGTC_2858|Compound:9025781|FD-Score:18.50|P-value:8.58E-62 ID:SGTC_2859|Compound:9028643|FD-Score:3.57|P-value:6.75E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.93|P-value:5.08E-6 ID:SGTC_3025|Compound:9087895|FD-Score:5.79|P-value:1.06E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.59|P-value:2.78E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.54|P-value:2.38E-5 ID:SGTC_3084|Compound:9116877|FD-Score:3.88|P-value:2.54E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.67|P-value:5.01E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.24|P-value:7.15E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.09|P-value:1.32E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:5.80|P-value:1.00E-7 ID:SGTC_56|Compound:0957-0365|FD-Score:4.07|P-value:1.33E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:7.56|P-value:6.61E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:3.58|P-value:6.58E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.73|P-value:4.09E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.20|P-value:5.80E-11 ID:SGTC_108|Compound:0509-0257|FD-Score:4.90|P-value:5.58E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:5.21|P-value:1.50E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.79|P-value:3.66E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.95|P-value:2.01E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.59|P-value:6.41E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.64|P-value:5.50E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.38|P-value:4.31E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.63|P-value:2.52E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.53|P-value:1.27E-14 ID:SGTC_315|Compound:k915-0449|FD-Score:4.31|P-value:5.49E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.76|P-value:3.72E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.56|P-value:7.02E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.53|P-value:3.69E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:8.35|P-value:3.87E-14 ID:SGTC_513|Compound:4245-1575|FD-Score:5.84|P-value:8.40E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:6.66|P-value:1.25E-9 ID:SGTC_533|Compound:1222-0222|FD-Score:3.78|P-value:3.49E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.30|P-value:1.01E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.76|P-value:1.02E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.95|P-value:4.63E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:5.42|P-value:5.92E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.22|P-value:7.70E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:6.60|P-value:1.74E-9 ID:SGTC_895|Compound:0964-0006|FD-Score:3.90|P-value:2.37E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.53|P-value:7.64E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:6.05|P-value:2.94E-8 ID:SGTC_994|Compound:3910-0338|FD-Score:4.49|P-value:2.86E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.39|P-value:6.95E-7 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.75|P-value:4.21E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.10|P-value:1.18E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.38|P-value:7.31E-7 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.51|P-value:2.68E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.63|P-value:5.61E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.90|P-value:2.35E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.39|P-value:6.74E-7 ID:SGTC_1304|Compound:1165-0502|FD-Score:11.40|P-value:9.48E-25 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.79|P-value:3.42E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.71|P-value:2.52E-12 ID:SGTC_1641|Compound:st009299|FD-Score:3.63|P-value:5.71E-4 ID:SGTC_1687|Compound:st020778|FD-Score:7.40|P-value:1.70E-11 ID:SGTC_1694|Compound:st024011|FD-Score:4.85|P-value:6.78E-6 ID:SGTC_1700|Compound:st030840|FD-Score:5.43|P-value:5.70E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.53|P-value:2.65E-5 ID:SGTC_1750|Compound:st081859|FD-Score:9.19|P-value:9.92E-17 ID:SGTC_1803|Compound:st050068|FD-Score:3.98|P-value:1.81E-4 ID:SGTC_1826|Compound:st055655|FD-Score:3.61|P-value:6.01E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:15.10|P-value:9.97E-42 ID:SGTC_1941|Compound:st076221|FD-Score:7.72|P-value:2.37E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.83|P-value:3.21E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.65|P-value:5.33E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.67|P-value:5.06E-4 ID:SGTC_2077|Compound:5212015|FD-Score:6.42|P-value:4.57E-9 ID:SGTC_2084|Compound:5306078|FD-Score:3.95|P-value:1.98E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.64|P-value:5.90E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.71|P-value:4.36E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.30|P-value:4.29E-17 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.83|P-value:7.65E-6 ID:SGTC_2421|Compound:5690543|FD-Score:3.63|P-value:5.60E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.06|P-value:1.37E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.45|P-value:5.19E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.53|P-value:7.66E-4 ID:SGTC_2526|Compound:patulin|FD-Score:7.60|P-value:4.95E-12 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.11|P-value:2.55E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.90|P-value:2.51E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.91|P-value:2.28E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:15.00|P-value:2.80E-41 ID:SGTC_2692|Compound:st077426|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.88|P-value:3.55E-10 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.92|P-value:2.41E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.75|P-value:3.81E-4 ID:SGTC_2858|Compound:9025781|FD-Score:18.50|P-value:8.58E-62 ID:SGTC_2859|Compound:9028643|FD-Score:3.57|P-value:6.75E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.93|P-value:5.08E-6 ID:SGTC_3025|Compound:9087895|FD-Score:5.79|P-value:1.06E-7 ID:SGTC_3059|Compound:1327-0034|FD-Score:5.59|P-value:2.78E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.54|P-value:2.38E-5 ID:SGTC_3084|Compound:9116877|FD-Score:3.88|P-value:2.54E-4

Top fitness defect scores for YBL079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2858 9025781 18.50 9.0 µM 8.58E-62 sphingolipid biosynthesis & PDR1 7 1.13E-76
2 SGTC_1877 wortmannin 15.10 25.0 µM 9.97E-42 2 1.31E-51
3 SGTC_2651 1327-0036 15.00 5.0 µM 2.80E-41 5 4.77E-51
4 SGTC_1304 1165-0502 11.40 251.0 µM 9.48E-25 6 2.04E-30
5 SGTC_2322 7413319 9.30 38.2 µM 4.29E-17 ERAD & cell cycle 24 7.17E-21
6 SGTC_1750 st081859 9.19 2.4 µM 9.92E-17 endomembrane recycling 49 2.04E-20
7 SGTC_505 gw-5074 8.35 63.9 µM 3.87E-14 17 3.45E-17
8 SGTC_1941 st076221 7.72 61.8 µM 2.37E-12 sphingolipid biosynthesis & PDR1 23 5.76E-15
9 SGTC_1495 4469-0029 7.71 237.0 µM 2.52E-12 26 6.23E-15
10 SGTC_2526 patulin 7.60 37.6 µM 4.95E-12 17 1.45E-14
11 SGTC_59 0330-0160 7.56 1.3 µM 6.61E-12 17 2.07E-14
12 SGTC_1687 st020778 7.40 55.4 µM 1.70E-11 78 6.70E-14
13 SGTC_103 0844-0104 7.20 51.8 µM 5.80E-11 ERAD & cell cycle 58 3.08E-13
14 SGTC_2752 diclazuril 6.88 33.1 µM 3.55E-10 48 2.93E-12
15 SGTC_528 3492-0019 6.66 172.0 µM 1.25E-9 calcium & mitochondrial duress 104 1.40E-11
16 SGTC_852 0418-0143 6.60 439.0 µM 1.74E-9 calcium & mitochondrial duress 20 2.12E-11
17 SGTC_2077 5212015 6.42 200.0 µM 4.57E-9 20 7.01E-11
18 SGTC_955 1216-0110 6.05 33.0 µM 2.94E-8 sphingolipid biosynthesis & PDR1 31 7.08E-10
19 SGTC_513 4245-1575 5.84 41.7 µM 8.40E-8 unfolded protein response 51 2.61E-9
20 SGTC_52 0329-0193 5.80 875.0 nM 1.00E-7 TSC3-RPN4 10 3.25E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.452 4.45E-168 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.422 4.08E-145 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.411 3.23E-137 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.372 2.12E-110 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.359 1.75E-102 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.358 6.54E-102 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.354 1.29E-99 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.345 2.27E-94 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.331 1.41E-86 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.328 4.30E-85 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.307 3.37E-74 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.302 1.31E-71 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.292 4.24E-67 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.290 3.64E-66 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.289 1.44E-65 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p