YBL083C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL083C / YBL083C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-7.07|P-value:5.61E-13 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.57|P-value:1.55E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.61|P-value:1.33E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:6.23|P-value:2.37E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:6.66|P-value:1.42E-11 ID:SGTC_121|Compound:0557-0495|FD-Score:6.13|P-value:4.45E-10 ID:SGTC_133|Compound:0724-0033|FD-Score:4.14|P-value:1.83E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.92|P-value:4.68E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.60|P-value:1.73E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.34|P-value:7.39E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.17|P-value:7.92E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.87|P-value:4.75E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.78|P-value:2.88E-9 ID:SGTC_329|Compound:k048-0121|FD-Score:3.30|P-value:5.06E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.01|P-value:3.13E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.20|P-value:1.40E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.31|P-value:5.57E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:4.48|P-value:3.83E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:4.39|P-value:5.85E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:4.91|P-value:4.65E-7 ID:SGTC_700|Compound:3453-2283|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.40|P-value:5.74E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:3.19|P-value:7.53E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:5.39|P-value:3.58E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.15|P-value:7.35E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.28|P-value:5.38E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.14|P-value:8.72E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.99|P-value:3.47E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:6.17|P-value:3.55E-10 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.52|P-value:1.90E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:-5.33|P-value:3.86E-8 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.77|P-value:8.70E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.00|P-value:3.37E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:5.10|P-value:1.76E-7 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.66|P-value:1.30E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.29|P-value:5.30E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.92|P-value:4.61E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-4.01|P-value:2.62E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.79|P-value:6.45E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.97|P-value:3.78E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.10|P-value:8.63E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.43|P-value:3.13E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.45|P-value:2.99E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.50|P-value:2.46E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.42|P-value:3.25E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.76|P-value:8.99E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.46|P-value:2.41E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.26|P-value:5.75E-4 ID:SGTC_2021|Compound:4019055|FD-Score:7.91|P-value:1.33E-15 ID:SGTC_2036|Compound:5160441|FD-Score:3.94|P-value:4.25E-5 ID:SGTC_2079|Compound:5212404|FD-Score:3.92|P-value:4.64E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.17|P-value:7.94E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.96|P-value:3.89E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.18|P-value:7.81E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.13|P-value:9.15E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.82|P-value:7.33E-7 ID:SGTC_2312|Compound:7706453|FD-Score:3.63|P-value:1.47E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.11|P-value:2.08E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:4.33E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.07|P-value:2.13E-7 ID:SGTC_2855|Compound:9016525|FD-Score:-3.60|P-value:1.37E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.39|P-value:5.87E-6 ID:SGTC_2954|Compound:9074818|FD-Score:5.73|P-value:5.09E-9 ID:SGTC_2955|Compound:9076254|FD-Score:3.34|P-value:4.42E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.53|P-value:2.19E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.35|P-value:4.25E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.29|P-value:5.20E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.18|P-value:7.76E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.64|P-value:1.19E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.14|P-value:8.80E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.21|P-value:6.99E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.07|P-value:5.61E-13 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.57|P-value:1.55E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.61|P-value:1.33E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:6.23|P-value:2.37E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:6.66|P-value:1.42E-11 ID:SGTC_121|Compound:0557-0495|FD-Score:6.13|P-value:4.45E-10 ID:SGTC_133|Compound:0724-0033|FD-Score:4.14|P-value:1.83E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.92|P-value:4.68E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.60|P-value:1.73E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.34|P-value:7.39E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.17|P-value:7.92E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.87|P-value:4.75E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.78|P-value:2.88E-9 ID:SGTC_329|Compound:k048-0121|FD-Score:3.30|P-value:5.06E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.01|P-value:3.13E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.20|P-value:1.40E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:5.31|P-value:5.57E-8 ID:SGTC_534|Compound:k292-0788|FD-Score:4.48|P-value:3.83E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:4.39|P-value:5.85E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:4.91|P-value:4.65E-7 ID:SGTC_700|Compound:3453-2283|FD-Score:3.53|P-value:2.15E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.40|P-value:5.74E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:3.19|P-value:7.53E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:5.39|P-value:3.58E-8 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.15|P-value:7.35E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.28|P-value:5.38E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.14|P-value:8.72E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.99|P-value:3.47E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:6.17|P-value:3.55E-10 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.52|P-value:1.90E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:-5.33|P-value:3.86E-8 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.77|P-value:8.70E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.00|P-value:3.37E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:5.10|P-value:1.76E-7 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.66|P-value:1.30E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.29|P-value:5.30E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.92|P-value:4.61E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:-4.01|P-value:2.62E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.79|P-value:6.45E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.97|P-value:3.78E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.10|P-value:8.63E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.43|P-value:3.13E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.45|P-value:2.99E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.50|P-value:2.46E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.42|P-value:3.25E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.76|P-value:8.99E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.46|P-value:2.41E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.26|P-value:5.75E-4 ID:SGTC_2021|Compound:4019055|FD-Score:7.91|P-value:1.33E-15 ID:SGTC_2036|Compound:5160441|FD-Score:3.94|P-value:4.25E-5 ID:SGTC_2079|Compound:5212404|FD-Score:3.92|P-value:4.64E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.17|P-value:7.94E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.96|P-value:3.89E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.54|P-value:2.12E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.18|P-value:7.81E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.13|P-value:9.15E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.82|P-value:7.33E-7 ID:SGTC_2312|Compound:7706453|FD-Score:3.63|P-value:1.47E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.11|P-value:2.08E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:4.33E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.07|P-value:2.13E-7 ID:SGTC_2855|Compound:9016525|FD-Score:-3.60|P-value:1.37E-4 ID:SGTC_2902|Compound:5787006|FD-Score:4.39|P-value:5.87E-6 ID:SGTC_2954|Compound:9074818|FD-Score:5.73|P-value:5.09E-9 ID:SGTC_2955|Compound:9076254|FD-Score:3.34|P-value:4.42E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.53|P-value:2.19E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.35|P-value:4.25E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.29|P-value:5.20E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.18|P-value:7.76E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.64|P-value:1.19E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.14|P-value:8.80E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.21|P-value:6.99E-4

Top fitness defect scores for YBL083C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 7.91 173.0 µM 1.33E-15 endomembrane recycling 23 1.33E-15
2 SGTC_115 0527-0192 6.66 112.0 µM 1.42E-11 11 1.38E-11
3 SGTC_114 0364-0001 6.23 490.3 µM 2.37E-10 8 2.30E-10
4 SGTC_1189 1431-2119 6.17 7.3 µM 3.55E-10 4 3.44E-10
5 SGTC_121 0557-0495 6.13 61.3 µM 4.45E-10 calcium & mitochondrial duress 17 4.31E-10
6 SGTC_2954 9074818 5.73 52.7 µM 5.09E-9 11 4.90E-9
7 SGTC_872 0588-0139 5.39 234.0 µM 3.58E-8 11 3.44E-8
8 SGTC_528 3492-0019 5.31 172.0 µM 5.57E-8 calcium & mitochondrial duress 145 5.35E-8
9 SGTC_1341 1486-1360 5.10 280.0 µM 1.76E-7 5 1.69E-7
10 SGTC_2737 bleomycin 5.07 30.5 nM 2.13E-7 Golgi 51 2.04E-7
11 SGTC_576 1073-0113 4.91 22.7 µM 4.65E-7 redox potentiating 37 4.45E-7
12 SGTC_2268 7933382 4.82 153.8 µM 7.33E-7 18 7.01E-7
13 SGTC_534 k292-0788 4.48 63.4 µM 3.83E-6 mitochondrial processes 20 3.65E-6
14 SGTC_708 3448-5400 4.40 146.0 µM 5.74E-6 33 5.47E-6
15 SGTC_542 3381-0244 4.39 89.3 µM 5.85E-6 27 5.58E-6
16 SGTC_2902 5787006 4.39 60.5 µM 5.87E-6 Golgi 19 5.60E-6
17 SGTC_143 4032-1194 4.34 15.7 µM 7.39E-6 49 7.05E-6
18 SGTC_439 amiodarone 4.20 34.4 µM 1.40E-5 NEO1-PIK1 89 1.34E-5
19 SGTC_133 0724-0033 4.14 378.9 µM 1.83E-5 24 1.74E-5
20 SGTC_2325 6158266 4.11 200.0 µM 2.08E-5 18 1.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.36E-35 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.209 1.87E-34 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.208 3.26E-34 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.202 3.37E-32 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.201 5.59E-32 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.197 1.26E-30 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.194 8.64E-30 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.186 1.85E-27 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.184 7.80E-27 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.183 1.47E-26 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.182 1.68E-26 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.182 1.71E-26 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.182 2.63E-26 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.180 7.14E-26 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.179 1.76E-25 YDR156W RPA14 hom RNA polymerase I subunit A14