YBL086C_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL086C / YBL086C

Click on Significant Values for Screen Details ID:SGTC_377|Compound:3970-0964|FD-Score:3.00|P-value:5.62E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.03|P-value:5.34E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.57|P-value:5.33E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.50|P-value:7.77E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:2.96|P-value:6.60E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.00|P-value:5.83E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.95|P-value:9.82E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:-2.86|P-value:9.84E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.14|P-value:3.38E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.56|P-value:3.76E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.81|P-value:1.45E-17 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.11|P-value:3.84E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.53|P-value:6.82E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.11|P-value:4.17E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.60|P-value:4.85E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.71|P-value:3.06E-5 ID:SGTC_1629|Compound:st005085|FD-Score:2.98|P-value:6.03E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.49|P-value:8.02E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-4.28|P-value:1.82E-6 ID:SGTC_1917|Compound:st066507|FD-Score:-4.96|P-value:4.06E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.98|P-value:8.45E-6 ID:SGTC_1964|Compound:st076914|FD-Score:2.90|P-value:8.27E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.14|P-value:3.42E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.99|P-value:5.95E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.48|P-value:7.99E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.60|P-value:6.36E-10 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-2.87|P-value:9.61E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.12|P-value:3.60E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.28|P-value:1.83E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.50|P-value:7.63E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-8.52|P-value:1.49E-20 ID:SGTC_2858|Compound:9025781|FD-Score:2.97|P-value:6.24E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.12|P-value:3.76E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.29|P-value:1.77E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.69|P-value:3.16E-5 ID:SGTC_3109|Compound:9122853|FD-Score:2.85|P-value:9.97E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.64|P-value:3.94E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.33|P-value:1.51E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.04|P-value:6.26E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:3.00|P-value:5.62E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.03|P-value:5.34E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.57|P-value:5.33E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.50|P-value:7.77E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:2.96|P-value:6.60E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.00|P-value:5.83E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.95|P-value:9.82E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:-2.86|P-value:9.84E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.14|P-value:3.38E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.56|P-value:3.76E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.81|P-value:1.45E-17 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.11|P-value:3.84E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.53|P-value:6.82E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.11|P-value:4.17E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.60|P-value:4.85E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.71|P-value:3.06E-5 ID:SGTC_1629|Compound:st005085|FD-Score:2.98|P-value:6.03E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.49|P-value:8.02E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-4.28|P-value:1.82E-6 ID:SGTC_1917|Compound:st066507|FD-Score:-4.96|P-value:4.06E-8 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.98|P-value:8.45E-6 ID:SGTC_1964|Compound:st076914|FD-Score:2.90|P-value:8.27E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.14|P-value:3.42E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.99|P-value:5.95E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.48|P-value:7.99E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.60|P-value:6.36E-10 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-2.87|P-value:9.61E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.12|P-value:3.60E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.28|P-value:1.83E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.50|P-value:7.63E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-8.52|P-value:1.49E-20 ID:SGTC_2858|Compound:9025781|FD-Score:2.97|P-value:6.24E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.12|P-value:3.76E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.29|P-value:1.77E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.69|P-value:3.16E-5 ID:SGTC_3109|Compound:9122853|FD-Score:2.85|P-value:9.97E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.64|P-value:3.94E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.33|P-value:1.51E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.04|P-value:6.26E-6

Top fitness defect scores for YBL086C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 5.60 64.0 µM 6.36E-10 sphingolipid biosynthesis & PDR1 22 1.07E-8
2 SGTC_955 1216-0110 4.56 33.0 µM 3.76E-7 sphingolipid biosynthesis & PDR1 50 2.53E-6
3 SGTC_1375 2910-0797 4.11 186.0 µM 4.17E-6 22 1.99E-5
4 SGTC_3108 9121785 3.69 49.5 µM 3.16E-5 19 1.13E-4
5 SGTC_3120 9124077 3.64 49.5 µM 3.94E-5 30 1.36E-4
6 SGTC_445 e6 berbamine 3.57 66.0 µM 5.33E-5 NEO1-PIK1 138 1.77E-4
7 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.48 3.7 µM 7.99E-5 130 2.50E-4
8 SGTC_3156 9099931 3.33 49.5 µM 1.51E-4 22 4.33E-4
9 SGTC_2987 9018338 3.29 71.4 µM 1.77E-4 RPP1 & pyrimidine depletion 46 4.97E-4
10 SGTC_2758 dehydroepiandrosterone 3.28 69.3 µM 1.83E-4 71 5.10E-4
11 SGTC_2640 pentamidine 3.12 10.4 µM 3.60E-4 mitochondrial processes 62 9.13E-4
12 SGTC_377 3970-0964 3.00 33.1 µM 5.62E-4 109 0.00134
13 SGTC_2270 7924575 2.99 90.9 µM 5.95E-4 RPP1 & pyrimidine depletion 61 0.00141
14 SGTC_1629 st005085 2.98 44.9 µM 6.03E-4 RPP1 & pyrimidine depletion 86 0.00142
15 SGTC_2858 9025781 2.97 9.0 µM 6.24E-4 sphingolipid biosynthesis & PDR1 167 0.00147
16 SGTC_528 3492-0019 2.96 172.0 µM 6.60E-4 calcium & mitochondrial duress 315 0.00154
17 SGTC_1964 st076914 2.90 61.0 µM 8.27E-4 RPP1 & pyrimidine depletion 68 0.00187
18 SGTC_3109 9122853 2.85 49.5 µM 9.97E-4 43 0.00220
19 SGTC_1819 st053448 2.80 58.6 µM 0.00117 amide catabolism 78 0.00253
20 SGTC_2607 solasodine 2.78 47.4 µM 0.00126 120 0.00269

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.343 1.67E-93 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.291 2.66E-66 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.263 7.29E-54 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.257 1.14E-51 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.252 1.46E-49 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.239 1.13E-44 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.230 1.91E-41 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.215 1.87E-36 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.211 4.89E-35 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 4.99E-35 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.210 9.28E-35 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.209 1.46E-34 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.209 2.53E-34 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.206 1.28E-33 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.204 6.18E-33 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS