YBL094C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL094C / YBL094C

Click on Significant Values for Screen Details ID:SGTC_214|Compound:4373-3496|FD-Score:3.06|P-value:3.65E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.00|P-value:3.69E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:2.93|P-value:6.24E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.38|P-value:9.52E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:2.83|P-value:8.92E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.91|P-value:7.65E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.50|P-value:4.10E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.66|P-value:2.59E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.08|P-value:3.37E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.70|P-value:1.60E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.97|P-value:5.32E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.06|P-value:3.67E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:2.87|P-value:7.79E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.33|P-value:1.19E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.87|P-value:7.83E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.36|P-value:1.03E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.23|P-value:1.80E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.87|P-value:7.72E-4 ID:SGTC_1673|Compound:st016611|FD-Score:6.25|P-value:2.05E-12 ID:SGTC_1774|Compound:st048371|FD-Score:2.85|P-value:8.33E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.62|P-value:3.08E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-3.17|P-value:1.77E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.34|P-value:1.11E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.93|P-value:4.74E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.26|P-value:1.20E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.73|P-value:1.81E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.21|P-value:1.96E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.05|P-value:2.95E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-2.82|P-value:7.29E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.46|P-value:4.98E-5 ID:SGTC_2436|Compound:5633522|FD-Score:3.05|P-value:3.85E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-2.75|P-value:9.66E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.18|P-value:1.88E-6 ID:SGTC_2926|Compound:9010726|FD-Score:3.34|P-value:1.13E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.55|P-value:2.28E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.06|P-value:3.65E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.00|P-value:3.69E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:2.93|P-value:6.24E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.38|P-value:9.52E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:2.83|P-value:8.92E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.91|P-value:7.65E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.50|P-value:4.10E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.66|P-value:2.59E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.08|P-value:3.37E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.70|P-value:1.60E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.97|P-value:5.32E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.06|P-value:3.67E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:2.87|P-value:7.79E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.33|P-value:1.19E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.87|P-value:7.83E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.36|P-value:1.03E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.23|P-value:1.80E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.87|P-value:7.72E-4 ID:SGTC_1673|Compound:st016611|FD-Score:6.25|P-value:2.05E-12 ID:SGTC_1774|Compound:st048371|FD-Score:2.85|P-value:8.33E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.62|P-value:3.08E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-3.17|P-value:1.77E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.34|P-value:1.11E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-2.93|P-value:4.74E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.26|P-value:1.20E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.73|P-value:1.81E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.21|P-value:1.96E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.05|P-value:2.95E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-2.82|P-value:7.29E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.46|P-value:4.98E-5 ID:SGTC_2436|Compound:5633522|FD-Score:3.05|P-value:3.85E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-2.75|P-value:9.66E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.18|P-value:1.88E-6 ID:SGTC_2926|Compound:9010726|FD-Score:3.34|P-value:1.13E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.55|P-value:2.28E-7

Top fitness defect scores for YBL094C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1673 st016611 6.25 27.3 µM 2.05E-12 13 2.07E-10
2 SGTC_3016 9080866 4.55 49.5 µM 2.28E-7 15 2.64E-6
3 SGTC_2858 9025781 4.18 9.0 µM 1.88E-6 sphingolipid biosynthesis & PDR1 88 1.48E-5
4 SGTC_545 4218-0007 3.91 221.0 µM 7.65E-6 28 4.64E-5
5 SGTC_2199 6590217 3.73 200.0 µM 1.81E-5 mitochondrial processes 5 9.39E-5
6 SGTC_640 3381-0960 3.66 37.1 µM 2.59E-5 19 1.26E-4
7 SGTC_1790 st045711 3.62 43.5 µM 3.08E-5 18 1.45E-4
8 SGTC_484 loperamide 3.38 105.0 µM 9.52E-5 9 3.67E-4
9 SGTC_1453 4237-0541 3.36 195.0 µM 1.03E-4 heme biosynthesis & mitochondrial translocase 43 3.91E-4
10 SGTC_1916 st067606 3.34 49.2 µM 1.11E-4 67 4.17E-4
11 SGTC_2926 9010726 3.34 65.2 µM 1.13E-4 47 4.23E-4
12 SGTC_1394 3474-0001 3.33 65.7 µM 1.19E-4 endomembrane recycling 61 4.40E-4
13 SGTC_1556 plumbagin 3.23 1.5 µM 1.80E-4 superoxide 34 6.17E-4
14 SGTC_2264 7948757 3.21 110.8 µM 1.96E-4 46 6.64E-4
15 SGTC_690 glyoxal 3.08 20.3 µM 3.37E-4 141 0.00104
16 SGTC_214 4373-3496 3.06 70.0 µM 3.65E-4 125 0.00111
17 SGTC_1349 flufenamic acid 3.06 69.0 µM 3.67E-4 49 0.00111
18 SGTC_2436 5633522 3.05 8.1 µM 3.85E-4 48 0.00116
19 SGTC_1283 0922-0125 2.97 16.4 µM 5.32E-4 63 0.00151
20 SGTC_309 k408-0051 2.93 1.5 µM 6.24E-4 138 0.00172

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.64E-16 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.137 1.69E-15 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.114 3.47E-11 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.111 1.20E-10 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.108 3.42E-10 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.108 3.65E-10 YKR104W YKR104W hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
0.101 5.01E-9 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.101 5.31E-9 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.100 7.22E-9 YML088W UFO1 hom F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
0.096 2.49E-8 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.096 2.72E-8 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.094 5.06E-8 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.093 7.58E-8 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.091 1.50E-7 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.090 1.93E-7 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member