YBL105C / PKC1

Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBL105C / PKC1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.09|P-value:3.22E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.40|P-value:1.47E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.22|P-value:1.71E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:12.80|P-value:3.98E-18 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.68|P-value:6.05E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:5.46|P-value:1.25E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.26|P-value:2.10E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:6.52|P-value:5.99E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.53|P-value:1.04E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:6.74|P-value:3.05E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-6.42|P-value:6.90E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:5.40|P-value:1.48E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.31|P-value:1.84E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-5.85|P-value:3.75E-5 ID:SGTC_251|Compound:melphalan|FD-Score:4.77|P-value:6.94E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.76|P-value:5.56E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.39|P-value:1.31E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.80|P-value:5.69E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.55|P-value:1.00E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.88|P-value:5.36E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.89|P-value:1.17E-11 ID:SGTC_462|Compound:ag-879|FD-Score:5.57|P-value:9.30E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.81|P-value:6.29E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.89|P-value:5.24E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:6.34|P-value:1.05E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:7.52|P-value:2.18E-7 ID:SGTC_629|Compound:3448-6466|FD-Score:-4.56|P-value:9.88E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.56|P-value:9.62E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:5.58|P-value:9.20E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:6.64|P-value:4.22E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:8.88|P-value:1.23E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:5.33|P-value:1.77E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.68|P-value:8.54E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.63|P-value:9.72E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:9.10|P-value:4.88E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.49|P-value:2.46E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.86|P-value:2.04E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:8.18|P-value:1.94E-8 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.74|P-value:5.91E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.80|P-value:4.98E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.73|P-value:6.06E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.86|P-value:5.62E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:9.71|P-value:3.42E-11 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:7.01|P-value:1.27E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:-5.80|P-value:4.25E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:7.25|P-value:5.62E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:-4.91|P-value:4.43E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.22|P-value:2.31E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.65|P-value:7.63E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.92|P-value:4.86E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:7.63|P-value:1.48E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:8.07|P-value:2.94E-8 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.87|P-value:4.80E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-6.93|P-value:1.38E-6 ID:SGTC_1567|Compound:st069303|FD-Score:5.42|P-value:1.40E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.59|P-value:5.87E-11 ID:SGTC_1602|Compound:st001878|FD-Score:-4.90|P-value:4.49E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.79|P-value:2.56E-6 ID:SGTC_1652|Compound:st011932|FD-Score:7.60|P-value:1.65E-7 ID:SGTC_1687|Compound:st020778|FD-Score:8.85|P-value:1.40E-9 ID:SGTC_1693|Compound:xanthone|FD-Score:4.67|P-value:8.87E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.66|P-value:9.04E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.92|P-value:4.89E-4 ID:SGTC_1769|Compound:st044406|FD-Score:5.04|P-value:3.69E-4 ID:SGTC_1773|Compound:st048542|FD-Score:8.16|P-value:2.14E-8 ID:SGTC_1793|Compound:st048256|FD-Score:7.70|P-value:1.16E-7 ID:SGTC_1801|Compound:st050089|FD-Score:4.90|P-value:5.09E-4 ID:SGTC_1831|Compound:st055328|FD-Score:6.74|P-value:3.00E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.63|P-value:6.97E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:8.22|P-value:1.67E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:9.27|P-value:2.34E-10 ID:SGTC_2019|Compound:4016004|FD-Score:6.56|P-value:5.42E-6 ID:SGTC_2021|Compound:4019055|FD-Score:6.87|P-value:2.02E-6 ID:SGTC_2124|Compound:5246320|FD-Score:4.75|P-value:7.31E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:10.20|P-value:3.20E-12 ID:SGTC_2183|Compound:6420625|FD-Score:6.64|P-value:4.21E-6 ID:SGTC_2223|Compound:6903751|FD-Score:5.44|P-value:1.31E-4 ID:SGTC_2225|Compound:6654152|FD-Score:7.50|P-value:2.41E-7 ID:SGTC_2229|Compound:7354935|FD-Score:6.70|P-value:3.48E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.21|P-value:1.77E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.83|P-value:5.36E-4 ID:SGTC_2289|Compound:7946404|FD-Score:11.80|P-value:8.26E-16 ID:SGTC_2307|Compound:7538926|FD-Score:10.20|P-value:3.48E-12 ID:SGTC_2308|Compound:7584454|FD-Score:8.40|P-value:8.42E-9 ID:SGTC_2309|Compound:7664088|FD-Score:-5.83|P-value:3.97E-5 ID:SGTC_2336|Compound:9001819|FD-Score:11.20|P-value:3.22E-14 ID:SGTC_2344|Compound:7990960|FD-Score:8.53|P-value:5.00E-9 ID:SGTC_2348|Compound:9022543|FD-Score:11.10|P-value:4.68E-14 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.96|P-value:8.92E-10 ID:SGTC_2430|Compound:5571206|FD-Score:9.85|P-value:1.79E-11 ID:SGTC_2431|Compound:5490079|FD-Score:5.41|P-value:1.42E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-5.50|P-value:9.75E-5 ID:SGTC_2471|Compound:5466956|FD-Score:9.90|P-value:1.46E-11 ID:SGTC_2475|Compound:5812728|FD-Score:15.80|P-value:1.03E-26 ID:SGTC_2508|Compound:celastrol|FD-Score:7.83|P-value:7.35E-8 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:13.70|P-value:1.24E-20 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:10.70|P-value:3.58E-13 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.57|P-value:9.84E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:8.12|P-value:2.45E-8 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.66|P-value:7.44E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.64|P-value:9.36E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.95|P-value:3.88E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.90|P-value:3.82E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:9.47|P-value:1.01E-10 ID:SGTC_2776|Compound:terbinafine|FD-Score:-5.92|P-value:3.05E-5 ID:SGTC_2825|Compound:7998094|FD-Score:8.77|P-value:1.95E-9 ID:SGTC_2858|Compound:9025781|FD-Score:6.32|P-value:1.10E-5 ID:SGTC_2926|Compound:9010726|FD-Score:-4.72|P-value:6.84E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.75|P-value:7.39E-4 ID:SGTC_2968|Compound:9090663|FD-Score:11.60|P-value:3.41E-15 ID:SGTC_2993|Compound:9054257|FD-Score:6.16|P-value:1.81E-5 ID:SGTC_3003|Compound:9075612|FD-Score:4.63|P-value:9.64E-4 ID:SGTC_3006|Compound:9075424|FD-Score:5.00|P-value:4.02E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.85|P-value:4.41E-5 ID:SGTC_3033|Compound:9090887|FD-Score:5.00|P-value:3.99E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.96|P-value:1.49E-6 ID:SGTC_3091|Compound:9116372|FD-Score:6.72|P-value:3.28E-6 ID:SGTC_3126|Compound:9127922|FD-Score:10.10|P-value:4.80E-12 ID:SGTC_3142|Compound:9086498|FD-Score:9.23|P-value:2.85E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-7.77|P-value:7.50E-8 ID:SGTC_3201|Compound:9113999|FD-Score:4.68|P-value:8.50E-4 ID:SGTC_3216|Compound:9129716|FD-Score:7.22|P-value:6.21E-7 ID:SGTC_3218|Compound:9131285|FD-Score:5.47|P-value:1.24E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.55|P-value:9.83E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.69|P-value:8.44E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-5.67|P-value:6.23E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:5.09|P-value:3.22E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.40|P-value:1.47E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:8.22|P-value:1.71E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:12.80|P-value:3.98E-18 ID:SGTC_71|Compound:0417-1750|FD-Score:-5.68|P-value:6.05E-5 ID:SGTC_104|Compound:0074-0074|FD-Score:5.46|P-value:1.25E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.26|P-value:2.10E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:6.52|P-value:5.99E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.53|P-value:1.04E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:6.74|P-value:3.05E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-6.42|P-value:6.90E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:5.40|P-value:1.48E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.31|P-value:1.84E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:-5.85|P-value:3.75E-5 ID:SGTC_251|Compound:melphalan|FD-Score:4.77|P-value:6.94E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.76|P-value:5.56E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.39|P-value:1.31E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.80|P-value:5.69E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.55|P-value:1.00E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.88|P-value:5.36E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.89|P-value:1.17E-11 ID:SGTC_462|Compound:ag-879|FD-Score:5.57|P-value:9.30E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.81|P-value:6.29E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.89|P-value:5.24E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:6.34|P-value:1.05E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:7.52|P-value:2.18E-7 ID:SGTC_629|Compound:3448-6466|FD-Score:-4.56|P-value:9.88E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.56|P-value:9.62E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:5.58|P-value:9.20E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:6.64|P-value:4.22E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:8.88|P-value:1.23E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:5.33|P-value:1.77E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.68|P-value:8.54E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.63|P-value:9.72E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:9.10|P-value:4.88E-10 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.49|P-value:2.46E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.86|P-value:2.04E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:8.18|P-value:1.94E-8 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.74|P-value:5.91E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.80|P-value:4.98E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.73|P-value:6.06E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.86|P-value:5.62E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:9.71|P-value:3.42E-11 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:7.01|P-value:1.27E-6 ID:SGTC_1318|Compound:1280-3875|FD-Score:-5.80|P-value:4.25E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:7.25|P-value:5.62E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:-4.91|P-value:4.43E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.22|P-value:2.31E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.65|P-value:7.63E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.92|P-value:4.86E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:7.63|P-value:1.48E-7 ID:SGTC_1556|Compound:plumbagin|FD-Score:8.07|P-value:2.94E-8 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:-4.87|P-value:4.80E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-6.93|P-value:1.38E-6 ID:SGTC_1567|Compound:st069303|FD-Score:5.42|P-value:1.40E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:9.59|P-value:5.87E-11 ID:SGTC_1602|Compound:st001878|FD-Score:-4.90|P-value:4.49E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.79|P-value:2.56E-6 ID:SGTC_1652|Compound:st011932|FD-Score:7.60|P-value:1.65E-7 ID:SGTC_1687|Compound:st020778|FD-Score:8.85|P-value:1.40E-9 ID:SGTC_1693|Compound:xanthone|FD-Score:4.67|P-value:8.87E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.66|P-value:9.04E-4 ID:SGTC_1749|Compound:st037932|FD-Score:4.92|P-value:4.89E-4 ID:SGTC_1769|Compound:st044406|FD-Score:5.04|P-value:3.69E-4 ID:SGTC_1773|Compound:st048542|FD-Score:8.16|P-value:2.14E-8 ID:SGTC_1793|Compound:st048256|FD-Score:7.70|P-value:1.16E-7 ID:SGTC_1801|Compound:st050089|FD-Score:4.90|P-value:5.09E-4 ID:SGTC_1831|Compound:st055328|FD-Score:6.74|P-value:3.00E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-5.63|P-value:6.97E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:8.22|P-value:1.67E-8 ID:SGTC_1875|Compound:nocodazole|FD-Score:9.27|P-value:2.34E-10 ID:SGTC_2019|Compound:4016004|FD-Score:6.56|P-value:5.42E-6 ID:SGTC_2021|Compound:4019055|FD-Score:6.87|P-value:2.02E-6 ID:SGTC_2124|Compound:5246320|FD-Score:4.75|P-value:7.31E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:10.20|P-value:3.20E-12 ID:SGTC_2183|Compound:6420625|FD-Score:6.64|P-value:4.21E-6 ID:SGTC_2223|Compound:6903751|FD-Score:5.44|P-value:1.31E-4 ID:SGTC_2225|Compound:6654152|FD-Score:7.50|P-value:2.41E-7 ID:SGTC_2229|Compound:7354935|FD-Score:6.70|P-value:3.48E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.21|P-value:1.77E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.83|P-value:5.36E-4 ID:SGTC_2289|Compound:7946404|FD-Score:11.80|P-value:8.26E-16 ID:SGTC_2307|Compound:7538926|FD-Score:10.20|P-value:3.48E-12 ID:SGTC_2308|Compound:7584454|FD-Score:8.40|P-value:8.42E-9 ID:SGTC_2309|Compound:7664088|FD-Score:-5.83|P-value:3.97E-5 ID:SGTC_2336|Compound:9001819|FD-Score:11.20|P-value:3.22E-14 ID:SGTC_2344|Compound:7990960|FD-Score:8.53|P-value:5.00E-9 ID:SGTC_2348|Compound:9022543|FD-Score:11.10|P-value:4.68E-14 ID:SGTC_2408|Compound:sulbentine|FD-Score:8.96|P-value:8.92E-10 ID:SGTC_2430|Compound:5571206|FD-Score:9.85|P-value:1.79E-11 ID:SGTC_2431|Compound:5490079|FD-Score:5.41|P-value:1.42E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-5.50|P-value:9.75E-5 ID:SGTC_2471|Compound:5466956|FD-Score:9.90|P-value:1.46E-11 ID:SGTC_2475|Compound:5812728|FD-Score:15.80|P-value:1.03E-26 ID:SGTC_2508|Compound:celastrol|FD-Score:7.83|P-value:7.35E-8 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:13.70|P-value:1.24E-20 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:10.70|P-value:3.58E-13 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.57|P-value:9.84E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:8.12|P-value:2.45E-8 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.66|P-value:7.44E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.64|P-value:9.36E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.95|P-value:3.88E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.90|P-value:3.82E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:9.47|P-value:1.01E-10 ID:SGTC_2776|Compound:terbinafine|FD-Score:-5.92|P-value:3.05E-5 ID:SGTC_2825|Compound:7998094|FD-Score:8.77|P-value:1.95E-9 ID:SGTC_2858|Compound:9025781|FD-Score:6.32|P-value:1.10E-5 ID:SGTC_2926|Compound:9010726|FD-Score:-4.72|P-value:6.84E-4 ID:SGTC_2928|Compound:9011484|FD-Score:4.75|P-value:7.39E-4 ID:SGTC_2968|Compound:9090663|FD-Score:11.60|P-value:3.41E-15 ID:SGTC_2993|Compound:9054257|FD-Score:6.16|P-value:1.81E-5 ID:SGTC_3003|Compound:9075612|FD-Score:4.63|P-value:9.64E-4 ID:SGTC_3006|Compound:9075424|FD-Score:5.00|P-value:4.02E-4 ID:SGTC_3027|Compound:9089541|FD-Score:5.85|P-value:4.41E-5 ID:SGTC_3033|Compound:9090887|FD-Score:5.00|P-value:3.99E-4 ID:SGTC_3081|Compound:9117243|FD-Score:6.96|P-value:1.49E-6 ID:SGTC_3091|Compound:9116372|FD-Score:6.72|P-value:3.28E-6 ID:SGTC_3126|Compound:9127922|FD-Score:10.10|P-value:4.80E-12 ID:SGTC_3142|Compound:9086498|FD-Score:9.23|P-value:2.85E-10 ID:SGTC_3152|Compound:9099253|FD-Score:-7.77|P-value:7.50E-8 ID:SGTC_3201|Compound:9113999|FD-Score:4.68|P-value:8.50E-4 ID:SGTC_3216|Compound:9129716|FD-Score:7.22|P-value:6.21E-7 ID:SGTC_3218|Compound:9131285|FD-Score:5.47|P-value:1.24E-4 ID:SGTC_3247|Compound:9135149|FD-Score:5.55|P-value:9.83E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.69|P-value:8.44E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-5.67|P-value:6.23E-5

Top fitness defect scores for YBL105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2475 5812728 15.80 15.0 µM 1.03E-26 mitochondrial processes 4 1.35E-56 6.70
2 SGTC_2510 benzyl isothiocyanate 13.70 8.3 µM 1.24E-20 2 2.98E-43 4.51
3 SGTC_70 0141-0289 12.80 43.3 µM 3.98E-18 mitochondrial stress 1 9.31E-38 2.37
4 SGTC_2289 7946404 11.80 165.1 µM 8.26E-16 4 1.11E-32 3.89
5 SGTC_2968 9090663 11.60 33.4 µM 3.41E-15 1 2.47E-31 4.46
6 SGTC_2336 9001819 11.20 198.7 µM 3.22E-14 heme biosynthesis & mitochondrial translocase 6 3.36E-29 0.13
7 SGTC_2348 9022543 11.10 33.4 µM 4.68E-14 mitochondrial processes 6 7.63E-29 1.04
8 SGTC_2519 cryptotanshinone 10.70 88.0 µM 3.58E-13 heme biosynthesis & mitochondrial translocase 4 6.51E-27 1.66
9 SGTC_2129 girgensonine 10.20 121.0 µM 3.20E-12 heme biosynthesis & mitochondrial translocase 5 7.84E-25 2.17
10 SGTC_2307 7538926 10.20 6.3 µM 3.48E-12 1 9.39E-25 1.17
11 SGTC_3126 9127922 10.10 49.5 µM 4.80E-12 fatty acid desaturase (OLE1) 5 1.90E-24 1.50
12 SGTC_2471 5466956 9.90 24.8 µM 1.46E-11 mitochondrial processes 6 2.15E-23 3.14
13 SGTC_2430 5571206 9.85 200.0 µM 1.79E-11 3 3.34E-23 2.06
14 SGTC_1188 1403-0014 9.71 4.6 µM 3.42E-11 mitochondrial stress 1 1.38E-22 1.64
15 SGTC_1597 7-benzyloxygramine 9.59 47.5 µM 5.87E-11 calcium & mitochondrial duress 18 4.49E-22 0.39
16 SGTC_2766 oltipraz 9.47 83.9 µM 1.01E-10 heme requiring 5 1.46E-21 0.11
17 SGTC_1875 nocodazole 9.27 6.0 µM 2.34E-10 tubulin folding & SWR complex 9 9.16E-21 0.39
18 SGTC_3142 9086498 9.23 49.5 µM 2.85E-10 iron homeostasis 9 1.41E-20 0.20
19 SGTC_966 1300-0360 9.10 30.2 µM 4.88E-10 heme requiring 3 4.55E-20 2.11
20 SGTC_2408 sulbentine 8.96 18.4 µM 8.92E-10 7 1.69E-19 0.63

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.320 1.41E-80 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.274 1.04E-58 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.263 2.69E-54 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.261 2.68E-53 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.236 1.03E-43 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.234 6.35E-43 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.221 1.68E-38 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.212 2.02E-35 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.212 2.78E-35 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.210 1.17E-34 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.200 1.40E-31 YKL165C MCD4 het Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
0.193 1.39E-29 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.190 1.06E-28 YGL048C RPT6 het ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
0.188 5.31E-28 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.187 1.15E-27 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p