YBR003W / COQ1

Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR003W / COQ1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.14|P-value:1.28E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:16.30|P-value:2.80E-57 ID:SGTC_67|Compound:0335-0847|FD-Score:20.30|P-value:1.42E-87 ID:SGTC_86|Compound:0417-1630|FD-Score:13.40|P-value:2.93E-39 ID:SGTC_87|Compound:0100-0052|FD-Score:4.47|P-value:7.63E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.38|P-value:5.60E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.25|P-value:1.84E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:6.32|P-value:4.20E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:8.31|P-value:3.12E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:2.28E-30 ID:SGTC_165|Compound:k038-0023|FD-Score:14.30|P-value:1.54E-44 ID:SGTC_168|Compound:3970-0862|FD-Score:4.40|P-value:1.03E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:4.20|P-value:2.45E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.87|P-value:9.46E-15 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:5.59E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:9.72|P-value:1.39E-21 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:7.35E-31 ID:SGTC_253|Compound:dyclonine|FD-Score:3.97|P-value:6.32E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.33|P-value:1.44E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.25|P-value:8.94E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.19|P-value:2.60E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.02|P-value:5.94E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:5.23|P-value:1.98E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:4.93|P-value:8.96E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:3.54|P-value:3.17E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.32|P-value:6.97E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.24|P-value:9.06E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.10|P-value:3.81E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.03|P-value:4.93E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.90|P-value:8.29E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.49|P-value:3.79E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:7.17|P-value:1.61E-12 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.30|P-value:1.59E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.50|P-value:3.74E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.82|P-value:1.14E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.66|P-value:2.11E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.24|P-value:9.22E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.02|P-value:5.09E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.53|P-value:3.29E-4 ID:SGTC_2029|Compound:5175081|FD-Score:4.26|P-value:1.90E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.64|P-value:2.03E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.46|P-value:8.19E-6 ID:SGTC_2268|Compound:7933382|FD-Score:5.34|P-value:1.12E-7 ID:SGTC_2384|Compound:9036245|FD-Score:6.25|P-value:6.50E-10 ID:SGTC_2390|Compound:9097792|FD-Score:4.26|P-value:1.93E-5 ID:SGTC_2401|Compound:5128683|FD-Score:4.63|P-value:3.68E-6 ID:SGTC_2433|Compound:5607874|FD-Score:3.45|P-value:4.51E-4 ID:SGTC_2444|Compound:5485484|FD-Score:6.36|P-value:3.20E-10 ID:SGTC_2459|Compound:5811157|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.97|P-value:4.02E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.72|P-value:2.50E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:7.72|P-value:2.95E-14 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-6.82|P-value:7.81E-12 ID:SGTC_2710|Compound:st078562|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.14|P-value:8.74E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.26|P-value:8.54E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.45|P-value:8.34E-6 ID:SGTC_2884|Compound:9058502|FD-Score:3.63|P-value:2.35E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.28|P-value:5.41E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.14|P-value:1.28E-9 ID:SGTC_64|Compound:000l-0018|FD-Score:16.30|P-value:2.80E-57 ID:SGTC_67|Compound:0335-0847|FD-Score:20.30|P-value:1.42E-87 ID:SGTC_86|Compound:0417-1630|FD-Score:13.40|P-value:2.93E-39 ID:SGTC_87|Compound:0100-0052|FD-Score:4.47|P-value:7.63E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.38|P-value:5.60E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.25|P-value:1.84E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:6.32|P-value:4.20E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:8.31|P-value:3.12E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:2.28E-30 ID:SGTC_165|Compound:k038-0023|FD-Score:14.30|P-value:1.54E-44 ID:SGTC_168|Compound:3970-0862|FD-Score:4.40|P-value:1.03E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:4.20|P-value:2.45E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.87|P-value:9.46E-15 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:5.59E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:9.72|P-value:1.39E-21 ID:SGTC_236|Compound:1509-0011|FD-Score:11.80|P-value:7.35E-31 ID:SGTC_253|Compound:dyclonine|FD-Score:3.97|P-value:6.32E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.33|P-value:1.44E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.25|P-value:8.94E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.19|P-value:2.60E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.02|P-value:5.94E-7 ID:SGTC_635|Compound:k038-0028|FD-Score:5.23|P-value:1.98E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:4.93|P-value:8.96E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:3.54|P-value:3.17E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.73|P-value:1.61E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.32|P-value:6.97E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.24|P-value:9.06E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.10|P-value:3.81E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.03|P-value:4.93E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.90|P-value:8.29E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.49|P-value:3.79E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:7.17|P-value:1.61E-12 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.30|P-value:1.59E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.50|P-value:3.74E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.82|P-value:1.14E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.66|P-value:2.11E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.24|P-value:9.22E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.02|P-value:5.09E-5 ID:SGTC_1979|Compound:st071809|FD-Score:3.53|P-value:3.29E-4 ID:SGTC_2029|Compound:5175081|FD-Score:4.26|P-value:1.90E-5 ID:SGTC_2166|Compound:5933061|FD-Score:-4.64|P-value:2.03E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.46|P-value:8.19E-6 ID:SGTC_2268|Compound:7933382|FD-Score:5.34|P-value:1.12E-7 ID:SGTC_2384|Compound:9036245|FD-Score:6.25|P-value:6.50E-10 ID:SGTC_2390|Compound:9097792|FD-Score:4.26|P-value:1.93E-5 ID:SGTC_2401|Compound:5128683|FD-Score:4.63|P-value:3.68E-6 ID:SGTC_2433|Compound:5607874|FD-Score:3.45|P-value:4.51E-4 ID:SGTC_2444|Compound:5485484|FD-Score:6.36|P-value:3.20E-10 ID:SGTC_2459|Compound:5811157|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.97|P-value:4.02E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.72|P-value:2.50E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:7.72|P-value:2.95E-14 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-6.82|P-value:7.81E-12 ID:SGTC_2710|Compound:st078562|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.14|P-value:8.74E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.26|P-value:8.54E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.45|P-value:8.34E-6 ID:SGTC_2884|Compound:9058502|FD-Score:3.63|P-value:2.35E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.28|P-value:5.41E-4

Top fitness defect scores for YBR003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 20.30 266.0 µM 1.42E-87 ubiquinone biosynthesis & proteasome 3 1.28E-91
2 SGTC_64 000l-0018 16.30 272.1 µM 2.80E-57 ubiquinone biosynthesis & proteasome 18 5.65E-60
3 SGTC_165 k038-0023 14.30 64.4 µM 1.54E-44 ubiquinone biosynthesis & proteasome 2 1.17E-46
4 SGTC_86 0417-1630 13.40 471.9 µM 2.93E-39 ubiquinone biosynthesis & proteasome 23 3.86E-41
5 SGTC_236 1509-0011 11.80 5.3 µM 7.35E-31 155 2.36E-32
6 SGTC_158 k038-0087 11.70 26.4 µM 2.28E-30 ubiquinone biosynthesis & proteasome 24 7.71E-32
7 SGTC_216 k038-0035 9.72 28.4 µM 1.39E-21 ubiquinone biosynthesis & proteasome 7 1.21E-22
8 SGTC_142 0335-0849 8.31 62.7 µM 3.12E-16 ubiquinone biosynthesis & proteasome 42 4.85E-17
9 SGTC_200 k038-0079 7.87 37.5 µM 9.46E-15 ubiquinone biosynthesis & proteasome 16 1.73E-15
10 SGTC_2565 isoliquiritigenin 7.72 100.0 µM 2.95E-14 4 5.71E-15
11 SGTC_1426 4048-4480 7.17 71.7 µM 1.61E-12 60S ribosome export 1 3.80E-13
12 SGTC_2444 5485484 6.36 36.4 µM 3.20E-10 4 9.77E-11
13 SGTC_137 0438-0332 6.32 85.4 µM 4.20E-10 ubiquinone biosynthesis & proteasome 58 1.30E-10
14 SGTC_2384 9036245 6.25 200.0 µM 6.50E-10 13 2.06E-10
15 SGTC_36 0335-0881 6.14 14.2 µM 1.28E-9 ubiquinone biosynthesis & proteasome 63 4.19E-10
16 SGTC_2268 7933382 5.34 153.8 µM 1.12E-7 14 4.57E-8
17 SGTC_134 0269-0018 5.25 6.9 µM 1.84E-7 96 7.74E-8
18 SGTC_635 k038-0028 5.23 24.7 µM 1.98E-7 ubiquinone biosynthesis & proteasome 25 8.33E-8
19 SGTC_386 1509-0011 5.02 3.1 µM 5.94E-7 107 2.65E-7
20 SGTC_794 k038-0031 4.93 316.0 µM 8.96E-7 ubiquinone biosynthesis & proteasome 82 4.08E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.670 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.659 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.635 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.633 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.628 0 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.624 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.610 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.571 6.54E-290 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.560 6.85E-277 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.545 2.47E-259 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.525 3.99E-237 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.522 2.28E-233 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.515 1.49E-226 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.510 1.64E-221 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.485 1.57E-197 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated