YBR029C / CDS1

Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR029C / CDS1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:-4.36|P-value:1.40E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.94|P-value:1.98E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:-4.56|P-value:7.20E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-5.99|P-value:3.15E-7 ID:SGTC_901|Compound:1112-0062|FD-Score:5.89|P-value:6.86E-7 ID:SGTC_997|Compound:3996-0078|FD-Score:-5.08|P-value:1.20E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-5.22|P-value:6.92E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.83|P-value:7.00E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.63|P-value:2.00E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.76|P-value:8.52E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.13|P-value:9.74E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.85|P-value:3.69E-5 ID:SGTC_1782|Compound:st039423|FD-Score:4.91|P-value:2.89E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.64|P-value:1.34E-6 ID:SGTC_1797|Compound:st048695|FD-Score:4.25|P-value:2.57E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.03|P-value:5.00E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.95|P-value:2.58E-5 ID:SGTC_1904|Compound:st060225|FD-Score:4.26|P-value:2.51E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.89|P-value:6.93E-7 ID:SGTC_1912|Compound:st060209|FD-Score:6.92|P-value:7.02E-9 ID:SGTC_1915|Compound:st067105|FD-Score:4.29|P-value:2.26E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.75|P-value:5.06E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.02|P-value:5.20E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-6.02|P-value:2.82E-7 ID:SGTC_2488|Compound:5268135|FD-Score:-3.97|P-value:4.56E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.47|P-value:9.68E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.53|P-value:1.05E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.94|P-value:5.06E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.17|P-value:1.15E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.74|P-value:9.00E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.02|P-value:1.46E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.93|P-value:5.18E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.81|P-value:7.36E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.73|P-value:4.13E-5 ID:SGTC_2905|Compound:7799065|FD-Score:-9.62|P-value:7.70E-16 ID:SGTC_2968|Compound:9090663|FD-Score:-3.74|P-value:8.89E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.07|P-value:4.48E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.43|P-value:1.47E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:-4.36|P-value:1.40E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.94|P-value:1.98E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:-4.56|P-value:7.20E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-5.99|P-value:3.15E-7 ID:SGTC_901|Compound:1112-0062|FD-Score:5.89|P-value:6.86E-7 ID:SGTC_997|Compound:3996-0078|FD-Score:-5.08|P-value:1.20E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-5.22|P-value:6.92E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.83|P-value:7.00E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.63|P-value:2.00E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.76|P-value:8.52E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.13|P-value:9.74E-6 ID:SGTC_1750|Compound:st081859|FD-Score:4.85|P-value:3.69E-5 ID:SGTC_1782|Compound:st039423|FD-Score:4.91|P-value:2.89E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.64|P-value:1.34E-6 ID:SGTC_1797|Compound:st048695|FD-Score:4.25|P-value:2.57E-4 ID:SGTC_1900|Compound:st060200|FD-Score:4.03|P-value:5.00E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.95|P-value:2.58E-5 ID:SGTC_1904|Compound:st060225|FD-Score:4.26|P-value:2.51E-4 ID:SGTC_1911|Compound:st060208|FD-Score:5.89|P-value:6.93E-7 ID:SGTC_1912|Compound:st060209|FD-Score:6.92|P-value:7.02E-9 ID:SGTC_1915|Compound:st067105|FD-Score:4.29|P-value:2.26E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.75|P-value:5.06E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.02|P-value:5.20E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-6.02|P-value:2.82E-7 ID:SGTC_2488|Compound:5268135|FD-Score:-3.97|P-value:4.56E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-4.47|P-value:9.68E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.53|P-value:1.05E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.94|P-value:5.06E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:5.17|P-value:1.15E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.74|P-value:9.00E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.02|P-value:1.46E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.93|P-value:5.18E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.81|P-value:7.36E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.73|P-value:4.13E-5 ID:SGTC_2905|Compound:7799065|FD-Score:-9.62|P-value:7.70E-16 ID:SGTC_2968|Compound:9090663|FD-Score:-3.74|P-value:8.89E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.07|P-value:4.48E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.43|P-value:1.47E-4

Top fitness defect scores for YBR029C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1912 st060209 6.92 90.8 µM 7.02E-9 2 2.32E-12 1.09
2 SGTC_901 1112-0062 5.89 60.1 µM 6.86E-7 1 1.89E-9 1.11
3 SGTC_1911 st060208 5.89 74.3 µM 6.93E-7 2 1.92E-9 0.42
4 SGTC_1375 2910-0797 5.63 186.0 µM 2.00E-6 1 9.00E-9 0.86
5 SGTC_2636 apigenin dimethyl ether 5.17 100.0 µM 1.15E-5 2 1.16E-7 0.05
6 SGTC_1902 st060212 4.95 70.5 µM 2.58E-5 3 3.77E-7 0.22
7 SGTC_1782 st039423 4.91 80.6 µM 2.89E-5 1 4.44E-7 0.50
8 SGTC_1750 st081859 4.85 2.4 µM 3.69E-5 endomembrane recycling 21 6.33E-7 0.01
9 SGTC_1916 st067606 4.75 49.2 µM 5.06E-5 2 1.00E-6 0.09
10 SGTC_2602 kawain 4.53 100.0 µM 1.05E-4 4 2.91E-6 0.34
11 SGTC_3146 9095609 4.43 49.5 µM 1.47E-4 3 4.72E-6 0.17
12 SGTC_1915 st067105 4.29 30.6 µM 2.26E-4 RNA pol III & RNase P/MRP 31 8.81E-6 0.12
13 SGTC_1904 st060225 4.26 78.0 µM 2.51E-4 3 1.03E-5 0.10
14 SGTC_1797 st048695 4.25 56.8 µM 2.57E-4 NEO1 12 1.07E-5 0.08
15 SGTC_3033 9090887 4.07 49.5 µM 4.48E-4 fatty acid desaturase (OLE1) 12 2.38E-5 0.02
16 SGTC_1900 st060200 4.03 72.8 µM 5.00E-4 4 2.79E-5 0.13
17 SGTC_2064 5220758 4.02 200.0 µM 5.20E-4 5 2.96E-5 0.02
18 SGTC_36 0335-0881 3.76 14.2 µM 0.00108 ubiquinone biosynthesis & proteasome 36 8.56E-5 0.12
19 SGTC_2796 7949634 3.75 45.5 µM 0.00111 11 8.89E-5 0.07
20 SGTC_568 1193-0097 3.69 7.5 µM 0.00131 ERAD & cell cycle 26 1.12E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.89E-22 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.154 3.76E-19 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.150 1.95E-18 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.150 2.00E-18 YBR140C IRA1 het GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
0.143 6.77E-17 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.139 6.02E-16 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.131 2.68E-14 YAL032C PRP45 het Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
0.118 5.90E-12 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.113 4.73E-11 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.113 5.16E-11 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.112 6.99E-11 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.112 7.60E-11 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.111 1.35E-10 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.110 1.78E-10 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.109 2.35E-10 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress