YBR039W / ATP3

Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR039W / ATP3

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.92|P-value:9.31E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:3.59|P-value:4.96E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.88|P-value:1.83E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.79|P-value:5.45E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:2.15E-30 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:1.48E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.51|P-value:9.68E-19 ID:SGTC_310|Compound:1273-0058|FD-Score:5.43|P-value:3.00E-7 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.85|P-value:1.71E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.48|P-value:7.05E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.70|P-value:6.27E-8 ID:SGTC_343|Compound:4130-2827|FD-Score:3.82|P-value:2.26E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:6.94|P-value:8.48E-11 ID:SGTC_386|Compound:1509-0011|FD-Score:4.82|P-value:4.63E-6 ID:SGTC_427|Compound:1354-0053|FD-Score:3.45|P-value:7.71E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.43|P-value:2.37E-7 ID:SGTC_462|Compound:ag-879|FD-Score:3.85|P-value:2.04E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.52|P-value:6.17E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.61|P-value:1.12E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.94|P-value:2.77E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.94|P-value:1.51E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.40|P-value:9.06E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.58|P-value:1.30E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:4.41|P-value:2.58E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.04|P-value:1.03E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.65|P-value:9.72E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:8.30|P-value:1.08E-14 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.98|P-value:1.87E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.31|P-value:5.13E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:9.52|P-value:8.47E-19 ID:SGTC_967|Compound:1306-0166|FD-Score:4.35|P-value:3.29E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.58|P-value:5.20E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.88|P-value:1.81E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.27|P-value:3.62E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.38|P-value:8.24E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.43|P-value:8.42E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.32|P-value:5.06E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.47|P-value:7.30E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-3.45|P-value:6.72E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.68|P-value:8.67E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.60|P-value:9.19E-13 ID:SGTC_1882|Compound:5615643|FD-Score:5.11|P-value:1.30E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.79|P-value:5.44E-6 ID:SGTC_1912|Compound:st060209|FD-Score:3.51|P-value:6.48E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.97|P-value:1.12E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.30|P-value:3.93E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.16|P-value:6.57E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.44|P-value:2.23E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.41|P-value:8.79E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.33|P-value:9.83E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.17|P-value:6.37E-5 ID:SGTC_2183|Compound:6420625|FD-Score:4.86|P-value:3.91E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.18|P-value:1.38E-17 ID:SGTC_2254|Compound:7938975|FD-Score:3.92|P-value:1.61E-4 ID:SGTC_2304|Compound:7443016|FD-Score:6.93|P-value:8.88E-11 ID:SGTC_2306|Compound:7482397|FD-Score:17.30|P-value:2.36E-57 ID:SGTC_2307|Compound:7538926|FD-Score:13.20|P-value:1.54E-34 ID:SGTC_2308|Compound:7584454|FD-Score:-6.30|P-value:2.50E-9 ID:SGTC_2312|Compound:7706453|FD-Score:4.94|P-value:2.85E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.99|P-value:2.29E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.93|P-value:1.56E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.87|P-value:1.93E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.54|P-value:5.00E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.47|P-value:6.22E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.86|P-value:3.13E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.63|P-value:1.10E-12 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.97|P-value:1.10E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.42|P-value:8.43E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.96|P-value:1.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.85|P-value:3.41E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.78|P-value:4.52E-6 ID:SGTC_3072|Compound:9116419|FD-Score:3.51|P-value:6.36E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-4.39|P-value:2.29E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.86|P-value:1.99E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.98|P-value:1.30E-4 ID:SGTC_3240|Compound:9133527|FD-Score:4.62|P-value:1.09E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.06|P-value:9.56E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:6.92|P-value:9.31E-11 ID:SGTC_116|Compound:0155-0182|FD-Score:3.59|P-value:4.96E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.88|P-value:1.83E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.79|P-value:5.45E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:2.15E-30 ID:SGTC_236|Compound:1509-0011|FD-Score:10.00|P-value:1.48E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.51|P-value:9.68E-19 ID:SGTC_310|Compound:1273-0058|FD-Score:5.43|P-value:3.00E-7 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.85|P-value:1.71E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.48|P-value:7.05E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.70|P-value:6.27E-8 ID:SGTC_343|Compound:4130-2827|FD-Score:3.82|P-value:2.26E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:6.94|P-value:8.48E-11 ID:SGTC_386|Compound:1509-0011|FD-Score:4.82|P-value:4.63E-6 ID:SGTC_427|Compound:1354-0053|FD-Score:3.45|P-value:7.71E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.43|P-value:2.37E-7 ID:SGTC_462|Compound:ag-879|FD-Score:3.85|P-value:2.04E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.52|P-value:6.17E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.61|P-value:1.12E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.94|P-value:2.77E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:3.94|P-value:1.51E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.40|P-value:9.06E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.58|P-value:1.30E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:4.41|P-value:2.58E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.04|P-value:1.03E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.65|P-value:9.72E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:8.30|P-value:1.08E-14 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.98|P-value:1.87E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:5.31|P-value:5.13E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:9.52|P-value:8.47E-19 ID:SGTC_967|Compound:1306-0166|FD-Score:4.35|P-value:3.29E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.58|P-value:5.20E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.88|P-value:1.81E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-4.27|P-value:3.62E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.38|P-value:8.24E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.43|P-value:8.42E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.32|P-value:5.06E-7 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.47|P-value:7.30E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:-3.45|P-value:6.72E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.78|P-value:2.61E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.68|P-value:8.67E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.60|P-value:9.19E-13 ID:SGTC_1882|Compound:5615643|FD-Score:5.11|P-value:1.30E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.79|P-value:5.44E-6 ID:SGTC_1912|Compound:st060209|FD-Score:3.51|P-value:6.48E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.97|P-value:1.12E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.30|P-value:3.93E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.16|P-value:6.57E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.44|P-value:2.23E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.41|P-value:8.79E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.33|P-value:9.83E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.17|P-value:6.37E-5 ID:SGTC_2183|Compound:6420625|FD-Score:4.86|P-value:3.91E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.18|P-value:1.38E-17 ID:SGTC_2254|Compound:7938975|FD-Score:3.92|P-value:1.61E-4 ID:SGTC_2304|Compound:7443016|FD-Score:6.93|P-value:8.88E-11 ID:SGTC_2306|Compound:7482397|FD-Score:17.30|P-value:2.36E-57 ID:SGTC_2307|Compound:7538926|FD-Score:13.20|P-value:1.54E-34 ID:SGTC_2308|Compound:7584454|FD-Score:-6.30|P-value:2.50E-9 ID:SGTC_2312|Compound:7706453|FD-Score:4.94|P-value:2.85E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.99|P-value:2.29E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.93|P-value:1.56E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.87|P-value:1.93E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.54|P-value:5.00E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.47|P-value:6.22E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.86|P-value:3.13E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.90|P-value:1.70E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.63|P-value:1.10E-12 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.97|P-value:1.10E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.42|P-value:8.43E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.96|P-value:1.14E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.85|P-value:3.41E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.78|P-value:4.52E-6 ID:SGTC_3072|Compound:9116419|FD-Score:3.51|P-value:6.36E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-4.39|P-value:2.29E-5 ID:SGTC_3181|Compound:9108277|FD-Score:3.86|P-value:1.99E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.98|P-value:1.30E-4 ID:SGTC_3240|Compound:9133527|FD-Score:4.62|P-value:1.09E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.06|P-value:9.56E-5

Top fitness defect scores for YBR039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2306 7482397 17.30 179.5 µM 2.36E-57 RPP1 & pyrimidine depletion 1 5.02E-67
2 SGTC_2307 7538926 13.20 6.3 µM 1.54E-34 1 2.87E-40
3 SGTC_173 1273-0061 12.40 2.7 µM 2.15E-30 mitochondrial stress 22 2.08E-35
4 SGTC_236 1509-0011 10.00 5.3 µM 1.48E-20 196 7.18E-24
5 SGTC_955 1216-0110 9.52 33.0 µM 8.47E-19 sphingolipid biosynthesis & PDR1 15 8.27E-22
6 SGTC_275 trichlorophene 9.51 5.7 µM 9.68E-19 mitochondrial stress 52 9.67E-22
7 SGTC_2250 alverine citrate 9.18 130.0 µM 1.38E-17 14 2.19E-20
8 SGTC_908 3448-7491 8.30 47.7 µM 1.08E-14 mitochondrial stress 16 5.39E-17
9 SGTC_2582 agaric acid 7.63 100.0 µM 1.10E-12 redox potentiating 112 1.22E-14
10 SGTC_365 0121-0052 6.94 13.6 µM 8.48E-11 mitochondrial response to ROS 12 1.98E-12
11 SGTC_2304 7443016 6.93 91.4 µM 8.88E-11 6 2.09E-12
12 SGTC_10 0279-0212 6.92 42.6 µM 9.31E-11 TRP & mitochondrial translation 13 2.21E-12
13 SGTC_310 1273-0058 5.43 1.1 µM 3.00E-7 mitochondrial stress 166 2.86E-8
14 SGTC_1318 1280-3875 5.32 124.0 µM 5.06E-7 7 5.26E-8
15 SGTC_920 mycophenolic acid 5.31 780.4 nM 5.13E-7 5 5.35E-8
16 SGTC_1882 5615643 5.11 20.0 µM 1.30E-6 TRP & mitochondrial translation 16 1.58E-7
17 SGTC_2336 9001819 4.99 198.7 µM 2.29E-6 heme biosynthesis & mitochondrial translocase 18 3.09E-7
18 SGTC_596 1155-0152 4.94 116.0 µM 2.77E-6 TRP & mitochondrial translation 17 3.86E-7
19 SGTC_2312 7706453 4.94 155.7 µM 2.85E-6 15 3.97E-7
20 SGTC_2183 6420625 4.86 130.5 µM 3.91E-6 mitochondrial processes 31 5.77E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.409 1.13E-135 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.403 4.78E-131 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.401 4.82E-130 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.390 1.93E-122 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.383 5.69E-118 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.371 5.03E-110 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.370 4.18E-109 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.364 2.81E-105 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.359 5.87E-103 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.357 2.24E-101 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.355 2.88E-100 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.352 2.86E-98 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.346 3.44E-95 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.346 6.56E-95 YDL202W MRPL11 hom Mitochondrial ribosomal protein of the large subunit
0.345 1.25E-94 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation