YBR045C / GIP1

Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR045C / GIP1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:8.07E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.18|P-value:3.73E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.72|P-value:2.22E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.36|P-value:1.89E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-6.06|P-value:4.82E-9 ID:SGTC_438|Compound:sphingosine|FD-Score:4.60|P-value:6.77E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:3.92|P-value:1.06E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.32|P-value:8.58E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.27|P-value:9.76E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.43|P-value:1.43E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.33|P-value:2.10E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.69|P-value:3.65E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.29|P-value:9.43E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.72|P-value:2.21E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.82|P-value:1.51E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:5.00|P-value:1.15E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.33|P-value:8.21E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.16|P-value:4.09E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.64|P-value:2.89E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.43|P-value:5.68E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.50|P-value:4.76E-4 ID:SGTC_1811|Compound:st050069|FD-Score:6.17|P-value:2.68E-9 ID:SGTC_1892|Compound:st058411|FD-Score:-4.00|P-value:7.43E-5 ID:SGTC_2150|Compound:5556613|FD-Score:-3.71|P-value:2.15E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.81|P-value:1.59E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.20|P-value:3.60E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.59|P-value:3.32E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.27|P-value:9.66E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.79|P-value:2.23E-8 ID:SGTC_2426|Compound:5582046|FD-Score:-5.39|P-value:1.66E-7 ID:SGTC_2432|Compound:5630864|FD-Score:-4.16|P-value:3.97E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.50|P-value:4.70E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.46|P-value:5.11E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.89|P-value:1.93E-6 ID:SGTC_2913|Compound:7966556|FD-Score:-3.44|P-value:5.47E-4 ID:SGTC_2986|Compound:9022445|FD-Score:4.48|P-value:1.12E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.55|P-value:3.95E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.14|P-value:4.28E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:8.07E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.18|P-value:3.73E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.72|P-value:2.22E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.36|P-value:1.89E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-6.06|P-value:4.82E-9 ID:SGTC_438|Compound:sphingosine|FD-Score:4.60|P-value:6.77E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:3.92|P-value:1.06E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.32|P-value:8.58E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.27|P-value:9.76E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.43|P-value:1.43E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.33|P-value:2.10E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.69|P-value:3.65E-8 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.29|P-value:9.43E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.72|P-value:2.21E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.82|P-value:1.51E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:5.00|P-value:1.15E-6 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.33|P-value:8.21E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.16|P-value:4.09E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.64|P-value:2.89E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-3.43|P-value:5.68E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.50|P-value:4.76E-4 ID:SGTC_1811|Compound:st050069|FD-Score:6.17|P-value:2.68E-9 ID:SGTC_1892|Compound:st058411|FD-Score:-4.00|P-value:7.43E-5 ID:SGTC_2150|Compound:5556613|FD-Score:-3.71|P-value:2.15E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.81|P-value:1.59E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.20|P-value:3.60E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.59|P-value:3.32E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.27|P-value:9.66E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.79|P-value:2.23E-8 ID:SGTC_2426|Compound:5582046|FD-Score:-5.39|P-value:1.66E-7 ID:SGTC_2432|Compound:5630864|FD-Score:-4.16|P-value:3.97E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.50|P-value:4.70E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.46|P-value:5.11E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.89|P-value:1.93E-6 ID:SGTC_2913|Compound:7966556|FD-Score:-3.44|P-value:5.47E-4 ID:SGTC_2986|Compound:9022445|FD-Score:4.48|P-value:1.12E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.55|P-value:3.95E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.14|P-value:4.28E-5

Top fitness defect scores for YBR045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1811 st050069 6.17 61.5 µM 2.68E-9 1 3.38E-10
2 SGTC_2409 alverine citrate 5.79 64.0 µM 2.23E-8 23 3.58E-9
3 SGTC_1257 0669-0121 5.69 16.0 µM 3.65E-8 4 6.21E-9
4 SGTC_1083 didemethylchlorpromazine sulfoxide 5.43 707.4 nM 1.43E-7 redox potentiating 38 2.83E-8
5 SGTC_1372 2752-0194 5.00 270.0 µM 1.15E-6 8 2.89E-7
6 SGTC_2797 7859098 4.89 81.8 µM 1.93E-6 11 5.14E-7
7 SGTC_438 sphingosine 4.60 6.7 µM 6.77E-6 13 2.08E-6
8 SGTC_2986 9022445 4.48 71.4 µM 1.12E-5 7 3.66E-6
9 SGTC_328 k915-0120 4.36 63.5 µM 1.89E-5 TSC3-RPN4 14 6.54E-6
10 SGTC_1245 0418-0076 4.33 17.2 µM 2.10E-5 ERG2 23 7.34E-6
11 SGTC_2251 lansoprazole 4.20 556.0 µM 3.60E-5 16 1.33E-5
12 SGTC_550 4123-0385 3.92 25.7 µM 1.06E-4 TSC3-RPN4 26 4.44E-5
13 SGTC_1239 0337-0584 3.84 35.4 µM 1.44E-4 unfolded protein response 60 6.24E-5
14 SGTC_1329 1447-1697 3.82 50.6 µM 1.51E-4 21 6.58E-5
15 SGTC_2200 6600604 3.81 21.9 µM 1.59E-4 tubulin folding & SWR complex 57 6.98E-5
16 SGTC_1294 1000-1494 3.72 117.0 µM 2.21E-4 28 1.00E-4
17 SGTC_313 3474-0040 3.72 5.0 µM 2.22E-4 NEO1-PIK1 81 1.01E-4
18 SGTC_1407 3909-7909 3.64 12.3 µM 2.89E-4 60S ribosome export 21 1.35E-4
19 SGTC_369 0957-0393 3.59 4.5 µM 3.45E-4 cell wall signaling 35 1.65E-4
20 SGTC_2367 9070478 3.59 135.4 µM 3.45E-4 cell wall 49 1.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.00E-21 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.138 8.05E-16 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.119 5.04E-12 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.117 1.26E-11 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.70E-11 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.114 3.29E-11 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.098 1.16E-8 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.094 4.34E-8 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.093 6.71E-8 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.092 1.04E-7 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.091 1.30E-7 YKR030W GMH1 hom Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
0.090 1.77E-7 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.089 2.71E-7 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.089 2.80E-7 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.084 1.18E-6 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication