HIPHOP chemogenomics database

YBR048W / RPS11B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR048W / RPS11B

Click on Significant Values for Screen Details

Top fitness defect scores for YBR048W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2688	kanamycin b	10.80	96.7 µM	1.24E-25	calcium & mitochondrial duress	18	1.16E-27
2	SGTC_2977	9011197	7.61	71.4 µM	1.40E-13		1	1.36E-14
3	SGTC_2845	9003024	6.65	43.0 µM	8.84E-11	amide catabolism	14	1.47E-11
4	SGTC_1518	st038567	6.02	90.8 µM	3.89E-9		3	8.91E-10
5	SGTC_358	0075-0058	5.73	9.4 µM	1.88E-8		20	4.90E-9
6	SGTC_625	k213-0058	5.56	121.0 µM	4.74E-8	translation	46	1.34E-8
7	SGTC_2610	ononetin	5.27	44.2 µM	2.09E-7		12	6.65E-8
8	SGTC_656	4090-1979	5.11	187.0 µM	4.82E-7		5	1.65E-7
9	SGTC_490	phenamil	5.10	164.0 µM	4.86E-7	heme requiring	4	1.66E-7
10	SGTC_1885	st057546	4.92	99.9 µM	1.16E-6		6	4.28E-7
11	SGTC_118	0083-0097	4.90	135.3 µM	1.28E-6	translation	64	4.75E-7
12	SGTC_2694	st077685	4.65	81.9 µM	4.05E-6	endomembrane recycling	16	1.65E-6
13	SGTC_665	3914-0008	4.51	307.0 µM	7.61E-6		11	3.26E-6
14	SGTC_1347	1493-0251	4.48	600.0 nM	8.57E-6	mitochondrial response to ROS	10	3.71E-6
15	SGTC_2911	7942208	4.47	15.6 µM	8.99E-6	mitochondrial response to ROS	11	3.91E-6
16	SGTC_620	0109-0052	4.30	432.0 µM	1.83E-5		10	8.42E-6
17	SGTC_2750	bromebric acid	4.27	70.2 µM	2.14E-5		21	9.98E-6
18	SGTC_1726	st035556	4.26	14.6 µM	2.18E-5		30	1.02E-5
19	SGTC_1348	1493-0373	4.01	93.8 µM	5.96E-5		12	3.02E-5
20	SGTC_2284	7945075	3.95	39.2 µM	7.45E-5	mitochondrial processes	26	3.85E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.202	3.73E-32	YLR367W	RPS22B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.196	2.52E-30	YDR447C	RPS17B	hom	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.195	4.36E-30	YLL045C	RPL8B	hom	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.164	1.20E-21	YFL036W	RPO41	hom	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.157	6.17E-20	YCR046C	IMG1	hom	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
0.153	4.10E-19	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.148	7.03E-18	YGR214W	RPS0A	hom	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.148	8.47E-18	YDL052C	SLC1	hom	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.143	7.05E-17	YBR191W	RPL21A	hom	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.138	9.41E-16	YNL227C	JJJ1	hom	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.131	3.20E-14	YER048C	CAJ1	hom	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.129	7.64E-14	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.128	1.18E-13	YGR118W	RPS23A	hom	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.124	6.96E-13	YLR402W_d	YLR402W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.123	8.81E-13	YNL067W	RPL9B	hom	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6