YBR049C / REB1

RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR049C / REB1

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:9.89|P-value:1.85E-22 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.95|P-value:5.87E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-5.34|P-value:7.73E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.22|P-value:8.37E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.64|P-value:1.93E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.31|P-value:6.14E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.38|P-value:9.42E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:3.98|P-value:5.21E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.21|P-value:1.96E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:1.93E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.66|P-value:1.60E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.68|P-value:2.40E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.30|P-value:5.83E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.72|P-value:1.44E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.28|P-value:6.24E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.97|P-value:4.69E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.57|P-value:2.46E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:5.19|P-value:1.98E-7 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.00|P-value:4.69E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.23|P-value:1.80E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.39|P-value:1.74E-10 ID:SGTC_1718|Compound:roemerine|FD-Score:3.22|P-value:8.53E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.37|P-value:4.98E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.81|P-value:1.14E-14 ID:SGTC_2046|Compound:4110841|FD-Score:3.33|P-value:5.80E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.43|P-value:3.74E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.18|P-value:9.52E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.54|P-value:2.79E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.44|P-value:3.95E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.20|P-value:8.11E-4 ID:SGTC_2585|Compound:alliin|FD-Score:4.24|P-value:1.74E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.88|P-value:9.17E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.05|P-value:3.44E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.56|P-value:2.27E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.96|P-value:3.45E-15 ID:SGTC_2701|Compound:st077767|FD-Score:3.39|P-value:4.69E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.19|P-value:9.28E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.48|P-value:3.13E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.56|P-value:2.33E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.57|P-value:2.22E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.25|P-value:7.57E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.54|P-value:4.69E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.44|P-value:3.96E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.71|P-value:1.46E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:9.89|P-value:1.85E-22 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.95|P-value:5.87E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-5.34|P-value:7.73E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.22|P-value:8.37E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.64|P-value:1.93E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.31|P-value:6.14E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.38|P-value:9.42E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:3.98|P-value:5.21E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:4.21|P-value:1.96E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.22|P-value:1.93E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.66|P-value:1.60E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.68|P-value:2.40E-6 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.30|P-value:5.83E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.72|P-value:1.44E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.28|P-value:6.24E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.97|P-value:4.69E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.57|P-value:2.46E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:5.19|P-value:1.98E-7 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.00|P-value:4.69E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.23|P-value:1.80E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:-6.39|P-value:1.74E-10 ID:SGTC_1718|Compound:roemerine|FD-Score:3.22|P-value:8.53E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.37|P-value:4.98E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.81|P-value:1.14E-14 ID:SGTC_2046|Compound:4110841|FD-Score:3.33|P-value:5.80E-4 ID:SGTC_2073|Compound:5212005|FD-Score:-3.43|P-value:3.74E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.18|P-value:9.52E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.54|P-value:2.79E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.44|P-value:3.95E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.20|P-value:8.11E-4 ID:SGTC_2585|Compound:alliin|FD-Score:4.24|P-value:1.74E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.88|P-value:9.17E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.05|P-value:3.44E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.56|P-value:2.27E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.96|P-value:3.45E-15 ID:SGTC_2701|Compound:st077767|FD-Score:3.39|P-value:4.69E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.19|P-value:9.28E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.48|P-value:3.13E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.56|P-value:2.33E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.57|P-value:2.22E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.25|P-value:7.57E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.54|P-value:4.69E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.44|P-value:3.96E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.71|P-value:1.46E-4

Top fitness defect scores for YBR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 9.89 7.5 µM 1.85E-22 17 2.21E-23 1.22
2 SGTC_2679 rapamycin 7.96 1.0 nM 3.45E-15 15 8.48E-16 0.02
3 SGTC_1844 rapamycin 7.81 4.0 nM 1.14E-14 15 2.94E-15 0.42
4 SGTC_1101 ebselen 5.19 5.3 µM 1.98E-7 3 1.05E-7 1.12
5 SGTC_2610 ononetin 4.88 44.2 µM 9.17E-7 3 5.20E-7 0.66
6 SGTC_674 0498-0004 4.68 451.0 µM 2.40E-6 heme requiring 10 1.42E-6 0.12
7 SGTC_3194 9111903 4.54 49.5 µM 4.69E-6 2 2.85E-6 0.50
8 SGTC_560 2332-1943 4.38 155.0 µM 9.42E-6 1 5.90E-6 0.34
9 SGTC_2585 alliin 4.24 100.0 µM 1.74E-5 6 1.12E-5 0.52
10 SGTC_1361 1608-0041 4.23 5.6 µM 1.80E-5 RPP1 & pyrimidine depletion 5 1.16E-5 0.97
11 SGTC_584 0986-0246 4.22 15.4 µM 1.93E-5 heme requiring 22 1.25E-5 0.02
12 SGTC_572 0960-0087 4.21 17.7 µM 1.96E-5 10 1.27E-5 0.14
13 SGTC_1273 0849-0096 4.00 14.1 µM 4.69E-5 RPP1 & pyrimidine depletion 7 3.15E-5 0.10
14 SGTC_561 1550-0330 3.98 72.9 µM 5.21E-5 3 3.52E-5 0.07
15 SGTC_262 fenpropimorph 3.95 62.5 µM 5.87E-5 ergosterol depletion effects on membrane 15 3.98E-5 0.15
16 SGTC_802 4112-3352 3.72 742.0 µM 1.44E-4 5 1.01E-4 0.42
17 SGTC_3280 9140961 3.71 49.5 µM 1.46E-4 60S ribosome export 7 1.03E-4 0.21
18 SGTC_522 1273-0010 3.64 11.6 µM 1.93E-4 60S ribosome export 7 1.37E-4 0.00
19 SGTC_1039 k821-0043 3.57 94.0 µM 2.46E-4 Golgi 7 1.78E-4 0.02
20 SGTC_2274 7947094 3.54 46.1 µM 2.79E-4 10 2.02E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 3.79E-79 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.274 1.17E-58 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.243 2.56E-46 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.237 3.17E-44 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.236 8.28E-44 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis
0.236 1.18E-43 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.214 5.76E-36 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.210 1.04E-34 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.209 2.83E-34 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.205 5.32E-33 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.195 4.21E-30 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.194 6.92E-30 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.191 4.65E-29 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.189 2.51E-28 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.186 1.25E-27 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M