YBR051W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR051W / YBR051W

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.73|P-value:9.91E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.83|P-value:7.76E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:-4.13|P-value:2.21E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.65|P-value:1.37E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.93|P-value:5.19E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:3.19|P-value:7.28E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.65|P-value:2.10E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.43|P-value:3.13E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.66|P-value:1.65E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:4.54|P-value:2.99E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:3.35|P-value:4.12E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.88|P-value:5.34E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:5.01|P-value:2.94E-7 ID:SGTC_958|Compound:1222-0007|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.47|P-value:3.00E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.24|P-value:6.84E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.26|P-value:1.09E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:-4.91|P-value:5.75E-7 ID:SGTC_1312|Compound:1218-2183|FD-Score:4.45|P-value:4.64E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.36|P-value:3.96E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.11|P-value:9.59E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.97|P-value:3.70E-5 ID:SGTC_1676|Compound:st018489|FD-Score:4.02|P-value:3.03E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.10|P-value:2.11E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.03|P-value:2.89E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.40|P-value:5.60E-6 ID:SGTC_1920|Compound:st075728|FD-Score:3.55|P-value:1.96E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.30|P-value:8.88E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.96|P-value:4.49E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.16|P-value:7.93E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.65|P-value:1.54E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.48|P-value:4.64E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.32|P-value:5.69E-8 ID:SGTC_2802|Compound:7925815|FD-Score:-3.43|P-value:3.50E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.37|P-value:3.83E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.54|P-value:2.37E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.92|P-value:4.51E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.73|P-value:9.91E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.83|P-value:7.76E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:-4.13|P-value:2.21E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.65|P-value:1.37E-4 ID:SGTC_276|Compound:colchicine|FD-Score:-3.93|P-value:5.19E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:3.19|P-value:7.28E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:-4.65|P-value:2.10E-6 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.43|P-value:3.13E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.66|P-value:1.65E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:4.54|P-value:2.99E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:3.35|P-value:4.12E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.88|P-value:5.34E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.50|P-value:2.41E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:5.01|P-value:2.94E-7 ID:SGTC_958|Compound:1222-0007|FD-Score:3.57|P-value:1.85E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.47|P-value:3.00E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.24|P-value:6.84E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:4.26|P-value:1.09E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:-4.91|P-value:5.75E-7 ID:SGTC_1312|Compound:1218-2183|FD-Score:4.45|P-value:4.64E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.36|P-value:3.96E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.11|P-value:9.59E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.97|P-value:3.70E-5 ID:SGTC_1676|Compound:st018489|FD-Score:4.02|P-value:3.03E-5 ID:SGTC_1779|Compound:st039427|FD-Score:4.10|P-value:2.11E-5 ID:SGTC_1859|Compound:st055998|FD-Score:4.03|P-value:2.89E-5 ID:SGTC_1860|Compound:st056228|FD-Score:4.40|P-value:5.60E-6 ID:SGTC_1920|Compound:st075728|FD-Score:3.55|P-value:1.96E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.30|P-value:8.88E-6 ID:SGTC_1932|Compound:st074806|FD-Score:-3.96|P-value:4.49E-5 ID:SGTC_1945|Compound:st075991|FD-Score:3.16|P-value:7.93E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.65|P-value:1.54E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.48|P-value:4.64E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.32|P-value:5.69E-8 ID:SGTC_2802|Compound:7925815|FD-Score:-3.43|P-value:3.50E-4 ID:SGTC_2879|Compound:9041815|FD-Score:3.37|P-value:3.83E-4 ID:SGTC_3051|Compound:9093778|FD-Score:-3.54|P-value:2.37E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.92|P-value:4.51E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.50|P-value:2.41E-4

Top fitness defect scores for YBR051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 5.32 100.0 µM 5.69E-8 redox potentiating 35 5.14E-8
2 SGTC_822 1487-0950 5.01 154.0 µM 2.94E-7 2 2.71E-7
3 SGTC_523 1934-0222 4.66 13.7 µM 1.65E-6 18 1.55E-6
4 SGTC_535 2293-4129 4.54 48.2 µM 2.99E-6 NEO1 47 2.81E-6
5 SGTC_1312 1218-2183 4.45 165.0 µM 4.64E-6 4 4.38E-6
6 SGTC_1860 st056228 4.40 74.6 µM 5.60E-6 7 5.30E-6
7 SGTC_1923 st058458 4.30 19.1 µM 8.88E-6 24 8.43E-6
8 SGTC_1229 0139-0193 4.26 12.2 µM 1.09E-5 RSC complex & mRNA processing 5 1.04E-5
9 SGTC_1779 st039427 4.10 55.0 µM 2.11E-5 24 2.02E-5
10 SGTC_1859 st055998 4.03 20.0 µM 2.89E-5 19 2.77E-5
11 SGTC_1676 st018489 4.02 23.4 µM 3.03E-5 60S ribosome export 32 2.91E-5
12 SGTC_1559 coumarin 343 3.97 70.1 µM 3.70E-5 13 3.56E-5
13 SGTC_3214 9129694 3.92 49.5 µM 4.51E-5 28 4.35E-5
14 SGTC_558 k064-0027 3.88 21.3 µM 5.34E-5 DNA damage response 26 5.15E-5
15 SGTC_65 0798-0905 3.73 35.0 µM 9.91E-5 calcium & mitochondrial duress 98 9.62E-5
16 SGTC_261 5-fluorouridine 3.65 15.4 µM 1.37E-4 exosome 19 1.33E-4
17 SGTC_958 1222-0007 3.57 33.0 µM 1.85E-4 40 1.81E-4
18 SGTC_1920 st075728 3.55 45.7 µM 1.96E-4 40 1.92E-4
19 SGTC_780 0109-0199 3.50 192.0 µM 2.41E-4 32 2.35E-4
20 SGTC_3216 9129716 3.50 49.5 µM 2.41E-4 RPP1 & pyrimidine depletion 40 2.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 1.76E-21 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.137 1.62E-15 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.130 4.30E-14 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.110 1.86E-10 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.096 2.58E-8 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.094 4.57E-8 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.093 7.91E-8 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.091 1.52E-7 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.088 3.32E-7 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.082 1.85E-6 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member
0.081 2.35E-6 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.079 4.19E-6 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.076 1.19E-5 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.075 1.29E-5 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.075 1.32E-5 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner