YBR052C / RFS1

Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR052C / RFS1

Click on Significant Values for Screen Details ID:SGTC_165|Compound:k038-0023|FD-Score:-2.61|P-value:9.16E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.00|P-value:1.56E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.15|P-value:7.71E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:4.06|P-value:5.39E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:3.08|P-value:1.08E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.77|P-value:4.33E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:2.85|P-value:3.12E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.03|P-value:1.38E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.08|P-value:1.07E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.23|P-value:5.11E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.63|P-value:8.27E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-2.75|P-value:5.10E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:2.63|P-value:7.89E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.79|P-value:3.99E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.35|P-value:2.77E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:2.57|P-value:9.79E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:2.96|P-value:1.82E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:2.94|P-value:2.06E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.70|P-value:5.92E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:2.97|P-value:1.80E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.23|P-value:5.07E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.03|P-value:1.34E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.19|P-value:6.65E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.09|P-value:1.02E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.78|P-value:4.13E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:2.80|P-value:3.85E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.84|P-value:3.20E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-2.59|P-value:9.85E-4 ID:SGTC_1637|Compound:st007924|FD-Score:2.92|P-value:2.21E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.14|P-value:8.20E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.50|P-value:1.29E-5 ID:SGTC_1885|Compound:st057546|FD-Score:2.81|P-value:3.68E-4 ID:SGTC_1966|Compound:st070145|FD-Score:2.63|P-value:7.90E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.36|P-value:2.67E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-2.83|P-value:3.60E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.22|P-value:5.32E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.65|P-value:5.67E-6 ID:SGTC_2290|Compound:7904846|FD-Score:2.70|P-value:5.74E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.03|P-value:1.35E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.40|P-value:2.37E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.15|P-value:8.32E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.76|P-value:4.80E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.15|P-value:3.09E-7 ID:SGTC_2795|Compound:7780010|FD-Score:-2.60|P-value:9.34E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-2.81|P-value:3.85E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.74|P-value:4.82E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.04|P-value:1.39E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.70|P-value:5.77E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.54|P-value:2.55E-8 ID:SGTC_3252|Compound:9135871|FD-Score:2.60|P-value:8.90E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-2.79|P-value:4.24E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-2.61|P-value:9.16E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.00|P-value:1.56E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.15|P-value:7.71E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:4.06|P-value:5.39E-7 ID:SGTC_368|Compound:fentichlor|FD-Score:3.08|P-value:1.08E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.77|P-value:4.33E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:2.85|P-value:3.12E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.03|P-value:1.38E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.08|P-value:1.07E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.23|P-value:5.11E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.63|P-value:8.27E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-2.75|P-value:5.10E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:2.63|P-value:7.89E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.79|P-value:3.99E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.35|P-value:2.77E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:2.57|P-value:9.79E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:2.96|P-value:1.82E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:2.94|P-value:2.06E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:2.70|P-value:5.92E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:2.97|P-value:1.80E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.23|P-value:5.07E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.03|P-value:1.34E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.19|P-value:6.65E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.09|P-value:1.02E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.78|P-value:4.13E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:2.80|P-value:3.85E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.84|P-value:3.20E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:-2.59|P-value:9.85E-4 ID:SGTC_1637|Compound:st007924|FD-Score:2.92|P-value:2.21E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.14|P-value:8.20E-5 ID:SGTC_1840|Compound:st055363|FD-Score:3.50|P-value:1.29E-5 ID:SGTC_1885|Compound:st057546|FD-Score:2.81|P-value:3.68E-4 ID:SGTC_1966|Compound:st070145|FD-Score:2.63|P-value:7.90E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.36|P-value:2.67E-5 ID:SGTC_2132|Compound:5317594|FD-Score:-2.83|P-value:3.60E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.22|P-value:5.32E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.65|P-value:5.67E-6 ID:SGTC_2290|Compound:7904846|FD-Score:2.70|P-value:5.74E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.03|P-value:1.35E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-3.40|P-value:2.37E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.15|P-value:8.32E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.76|P-value:4.80E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.15|P-value:3.09E-7 ID:SGTC_2795|Compound:7780010|FD-Score:-2.60|P-value:9.34E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-2.81|P-value:3.85E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.74|P-value:4.82E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.04|P-value:1.39E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.70|P-value:5.77E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.54|P-value:2.55E-8 ID:SGTC_3252|Compound:9135871|FD-Score:2.60|P-value:8.90E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-2.79|P-value:4.24E-4

Top fitness defect scores for YBR052C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3210 9128157 4.54 49.5 µM 2.55E-8 33 2.88E-6
2 SGTC_2698 st077697 4.15 67.5 µM 3.09E-7 15 1.66E-5
3 SGTC_259 usnic acid 4.06 108.9 µM 5.39E-7 16 2.46E-5
4 SGTC_2160 5660466 3.65 132.9 µM 5.67E-6 60S ribosome export 27 1.30E-4
5 SGTC_1840 st055363 3.50 71.0 µM 1.29E-5 25 2.32E-4
6 SGTC_1971 st069429 3.36 63.5 µM 2.67E-5 60S ribosome export 27 3.88E-4
7 SGTC_808 0711-0032 3.35 135.0 µM 2.77E-5 34 3.97E-4
8 SGTC_1140 3229-1848 3.23 3.0 µM 5.07E-5 22 6.10E-4
9 SGTC_456 gingerol 3.23 170.0 µM 5.11E-5 46 6.14E-4
10 SGTC_2158 5657123 3.22 3.6 µM 5.32E-5 19 6.32E-4
11 SGTC_183 3914-0051 3.15 30.6 µM 7.71E-5 60S ribosome export 54 8.22E-4
12 SGTC_1824 st053723 3.14 68.6 µM 8.20E-5 67 8.59E-4
13 SGTC_1388 3346-4487 3.09 254.0 µM 1.02E-4 56 0.00100
14 SGTC_453 enantio-paf c16 3.08 10.0 µM 1.07E-4 235 0.00104
15 SGTC_368 fentichlor 3.08 4.6 µM 1.08E-4 58 0.00104
16 SGTC_1251 0490-5699 3.03 265.0 µM 1.34E-4 83 0.00122
17 SGTC_2334 9017922 3.03 200.0 µM 1.35E-4 60 0.00123
18 SGTC_407 eburnamonine 3.03 100.0 µM 1.38E-4 48 0.00124
19 SGTC_182 3448-4371 3.00 550.5 µM 1.56E-4 58 0.00135
20 SGTC_973 1325-0077 2.97 65.9 µM 1.80E-4 46 0.00150

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.51E-15 YAL042W ERV46 hom Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
0.136 2.64E-15 YGR035W-A_p YGR035W-A_p hom Putative protein of unknown function
0.127 1.67E-13 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.119 4.05E-12 YBR203W COS111 hom Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.118 8.24E-12 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.115 2.05E-11 YAR019C CDC15 het Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.114 3.32E-11 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.113 4.70E-11 YMR302C YME2 hom Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
0.109 2.79E-10 YLR166C SEC10 het Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion
0.107 4.71E-10 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.106 8.35E-10 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.101 5.10E-9 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.098 1.11E-8 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.096 2.38E-8 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.093 7.86E-8 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall