HIPHOP chemogenomics database

YBR052C / RFS1

Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR052C / RFS1

Click on Significant Values for Screen Details

Top fitness defect scores for YBR052C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3210	9128157	4.54	49.5 µM	2.55E-8		33	2.88E-6
2	SGTC_2698	st077697	4.15	67.5 µM	3.09E-7		15	1.66E-5
3	SGTC_259	usnic acid	4.06	108.9 µM	5.39E-7		16	2.46E-5
4	SGTC_2160	5660466	3.65	132.9 µM	5.67E-6	60S ribosome export	27	1.30E-4
5	SGTC_1840	st055363	3.50	71.0 µM	1.29E-5		25	2.32E-4
6	SGTC_1971	st069429	3.36	63.5 µM	2.67E-5	60S ribosome export	27	3.88E-4
7	SGTC_808	0711-0032	3.35	135.0 µM	2.77E-5		34	3.97E-4
8	SGTC_1140	3229-1848	3.23	3.0 µM	5.07E-5		22	6.10E-4
9	SGTC_456	gingerol	3.23	170.0 µM	5.11E-5		46	6.14E-4
10	SGTC_2158	5657123	3.22	3.6 µM	5.32E-5		19	6.32E-4
11	SGTC_183	3914-0051	3.15	30.6 µM	7.71E-5	60S ribosome export	54	8.22E-4
12	SGTC_1824	st053723	3.14	68.6 µM	8.20E-5		67	8.59E-4
13	SGTC_1388	3346-4487	3.09	254.0 µM	1.02E-4		56	0.00100
14	SGTC_453	enantio-paf c16	3.08	10.0 µM	1.07E-4		235	0.00104
15	SGTC_368	fentichlor	3.08	4.6 µM	1.08E-4		58	0.00104
16	SGTC_1251	0490-5699	3.03	265.0 µM	1.34E-4		83	0.00122
17	SGTC_2334	9017922	3.03	200.0 µM	1.35E-4		60	0.00123
18	SGTC_407	eburnamonine	3.03	100.0 µM	1.38E-4		48	0.00124
19	SGTC_182	3448-4371	3.00	550.5 µM	1.56E-4		58	0.00135
20	SGTC_973	1325-0077	2.97	65.9 µM	1.80E-4		46	0.00150

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.136	2.51E-15	YAL042W	ERV46	hom	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
0.136	2.64E-15	YGR035W-A_p	YGR035W-A_p	hom	Putative protein of unknown function
0.127	1.67E-13	YLL017W	YLL017W	hom	Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.119	4.05E-12	YBR203W	COS111	hom	Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.118	8.24E-12	YDL079C	MRK1	hom	Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.115	2.05E-11	YAR019C	CDC15	het	Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
0.114	3.32E-11	YJR010W	MET3	hom	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.113	4.70E-11	YMR302C	YME2	hom	Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
0.109	2.79E-10	YLR166C	SEC10	het	Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion
0.107	4.71E-10	YJL200C	ACO2	hom	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.106	8.35E-10	YMR183C	SSO2	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.101	5.10E-9	YDR105C	TMS1	hom	Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.098	1.11E-8	YGL142C	GPI10	het	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.096	2.38E-8	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.093	7.86E-8	YLR390W-A	CCW14	hom	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall