YBR054W / YRO2

Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR054W / YRO2

Click on Significant Values for Screen Details ID:SGTC_259|Compound:usnic acid|FD-Score:3.05|P-value:3.20E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.90|P-value:5.99E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:2.90|P-value:5.80E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.82|P-value:6.25E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.18|P-value:1.33E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:2.78|P-value:9.54E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.69|P-value:9.83E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.22|P-value:1.54E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.01|P-value:3.82E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.69|P-value:1.17E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-2.84|P-value:5.54E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-2.81|P-value:6.29E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.83|P-value:8.75E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:2.90|P-value:6.03E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.46|P-value:3.72E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:2.79|P-value:9.16E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.52|P-value:4.00E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.83|P-value:7.84E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-2.81|P-value:6.27E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.40|P-value:6.89E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.23|P-value:1.01E-6 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.88|P-value:6.28E-4 ID:SGTC_1665|Compound:st014639|FD-Score:-3.80|P-value:6.91E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:2.91|P-value:5.61E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:2.91|P-value:5.68E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.54|P-value:3.69E-5 ID:SGTC_1881|Compound:5652484|FD-Score:2.86|P-value:6.81E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.17|P-value:1.42E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.77|P-value:7.28E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.70|P-value:9.50E-4 ID:SGTC_2123|Compound:5259487|FD-Score:2.97|P-value:4.52E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.74|P-value:8.26E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.81|P-value:6.25E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.96|P-value:4.65E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.96|P-value:7.70E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.86|P-value:6.98E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.01|P-value:2.78E-4 ID:SGTC_2483|Compound:5729050|FD-Score:5.13|P-value:3.90E-9 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.29|P-value:8.17E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.01|P-value:2.78E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-2.73|P-value:8.60E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.84|P-value:8.20E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.25|P-value:9.93E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.33|P-value:1.02E-9 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.20|P-value:1.23E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.78|P-value:1.14E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.70|P-value:6.30E-8 ID:SGTC_3113|Compound:9123498|FD-Score:-3.14|P-value:1.62E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.05|P-value:3.20E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:2.90|P-value:5.99E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:2.90|P-value:5.80E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.82|P-value:6.25E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.18|P-value:1.33E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:2.78|P-value:9.54E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.69|P-value:9.83E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.22|P-value:1.54E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.01|P-value:3.82E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.69|P-value:1.17E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-2.84|P-value:5.54E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-2.81|P-value:6.29E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.83|P-value:8.75E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:2.90|P-value:6.03E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.46|P-value:3.72E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:2.79|P-value:9.16E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.52|P-value:4.00E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.83|P-value:7.84E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-2.81|P-value:6.27E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.40|P-value:6.89E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.23|P-value:1.01E-6 ID:SGTC_1507|Compound:4075-3230|FD-Score:2.88|P-value:6.28E-4 ID:SGTC_1665|Compound:st014639|FD-Score:-3.80|P-value:6.91E-6 ID:SGTC_1693|Compound:xanthone|FD-Score:2.91|P-value:5.61E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:2.91|P-value:5.68E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.54|P-value:3.69E-5 ID:SGTC_1881|Compound:5652484|FD-Score:2.86|P-value:6.81E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.17|P-value:1.42E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-2.77|P-value:7.28E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.70|P-value:9.50E-4 ID:SGTC_2123|Compound:5259487|FD-Score:2.97|P-value:4.52E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-2.74|P-value:8.26E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.81|P-value:6.25E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_2287|Compound:7945887|FD-Score:2.96|P-value:4.65E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-4.96|P-value:7.70E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.86|P-value:6.98E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.01|P-value:2.78E-4 ID:SGTC_2483|Compound:5729050|FD-Score:5.13|P-value:3.90E-9 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.29|P-value:8.17E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.01|P-value:2.78E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-2.73|P-value:8.60E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.84|P-value:8.20E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.25|P-value:9.93E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.33|P-value:1.02E-9 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.20|P-value:1.23E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.78|P-value:1.14E-5 ID:SGTC_2919|Compound:7978188|FD-Score:4.70|P-value:6.30E-8 ID:SGTC_3113|Compound:9123498|FD-Score:-3.14|P-value:1.62E-4

Top fitness defect scores for YBR054W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2604 4'-hydroxychalcone 5.33 11.3 µM 1.02E-9 10 4.95E-8
2 SGTC_2483 5729050 5.13 27.2 µM 3.90E-9 9 1.43E-7
3 SGTC_2919 7978188 4.70 46.4 µM 6.30E-8 10 1.29E-6
4 SGTC_1475 4092-1048 4.23 11.7 µM 1.01E-6 plasma membrane duress 27 1.17E-5
5 SGTC_2572 astragaloside iv 3.84 100.0 µM 8.20E-6 29 6.14E-5
6 SGTC_1182 1222-0449 3.83 220.0 µM 8.75E-6 23 6.46E-5
7 SGTC_2703 st077852 3.78 53.4 µM 1.14E-5 29 7.97E-5
8 SGTC_1836 st055642 3.54 81.0 µM 3.69E-5 32 2.03E-4
9 SGTC_1314 1222-0010 3.52 41.1 µM 4.00E-5 21 2.17E-4
10 SGTC_1464 k208-0027 3.40 110.0 µM 6.89E-5 38 3.34E-4
11 SGTC_1156 4092-0367 3.24 4.9 µM 1.41E-4 56 5.92E-4
12 SGTC_940 3232-1287 3.22 54.8 µM 1.54E-4 NEO1 69 6.37E-4
13 SGTC_2258 7960471 3.19 200.0 µM 1.77E-4 33 7.11E-4
14 SGTC_259 usnic acid 3.05 108.9 µM 3.20E-4 52 0.00114
15 SGTC_1004 4084-0029 3.01 199.0 µM 3.82E-4 60 0.00131
16 SGTC_2123 5259487 2.97 200.0 µM 4.52E-4 59 0.00150
17 SGTC_2287 7945887 2.96 168.8 µM 4.65E-4 38 0.00154
18 SGTC_1693 xanthone 2.91 101.9 µM 5.61E-4 DNA damage response 51 0.00179
19 SGTC_1718 roemerine 2.91 11.9 µM 5.68E-4 redox potentiating 126 0.00181
20 SGTC_704 1310-0270 2.90 142.0 µM 5.80E-4 90 0.00184

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.80E-13 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.111 1.18E-10 YMR271C URA10 hom Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.111 1.26E-10 YOL068C HST1 hom NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance
0.095 3.44E-8 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.094 4.43E-8 YJR037W_d YJR037W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces
0.094 5.68E-8 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.090 1.99E-7 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.084 9.77E-7 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.080 3.42E-6 YMR075W RCO1 hom Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.077 7.35E-6 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.077 7.42E-6 YBL107C MIC23 hom Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)
0.077 7.59E-6 YMR274C RCE1 hom Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
0.077 8.46E-6 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.076 1.15E-5 YLR001C_p YLR001C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
0.075 1.52E-5 YJR107W_p YJR107W_p hom Putative lipase