YBR058C / UBP14

Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR058C / UBP14

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:4.45|P-value:1.04E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:6.91|P-value:2.53E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:5.02|P-value:7.98E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:3.24|P-value:9.03E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.66|P-value:3.75E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:6.79E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.70|P-value:9.36E-11 ID:SGTC_653|Compound:0203-0016|FD-Score:3.32|P-value:6.96E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.99|P-value:6.63E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.71|P-value:1.86E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.62|P-value:2.55E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.46|P-value:7.09E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.52|P-value:5.92E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.58|P-value:4.83E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.24|P-value:9.06E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-5.78|P-value:3.85E-8 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.30|P-value:7.38E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.16|P-value:4.12E-7 ID:SGTC_1618|Compound:st003135|FD-Score:3.79|P-value:1.39E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.62|P-value:2.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.71|P-value:3.33E-6 ID:SGTC_1682|Compound:st012968|FD-Score:4.41|P-value:1.23E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.09|P-value:5.76E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.60|P-value:4.46E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.78|P-value:2.41E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.60|P-value:2.73E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.22|P-value:9.53E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.52|P-value:5.94E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.30|P-value:7.55E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.38|P-value:1.38E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.52|P-value:3.60E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.56|P-value:3.09E-4 ID:SGTC_2399|Compound:5884133|FD-Score:7.24|P-value:2.84E-12 ID:SGTC_2477|Compound:5967686|FD-Score:5.60|P-value:4.74E-8 ID:SGTC_2485|Compound:5633444|FD-Score:-4.93|P-value:2.47E-6 ID:SGTC_2486|Compound:5283202|FD-Score:-3.65|P-value:3.77E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.10|P-value:4.28E-5 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.50|P-value:3.88E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.37|P-value:5.88E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.40|P-value:8.61E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.54|P-value:3.32E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.94|P-value:7.44E-9 ID:SGTC_3310|Compound:9130229|FD-Score:-3.68|P-value:3.48E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.83|P-value:1.21E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-4.42|P-value:2.12E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:4.45|P-value:1.04E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:6.91|P-value:2.53E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:5.02|P-value:7.98E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:3.24|P-value:9.03E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.66|P-value:3.75E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:6.79E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:6.70|P-value:9.36E-11 ID:SGTC_653|Compound:0203-0016|FD-Score:3.32|P-value:6.96E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.99|P-value:6.63E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.71|P-value:1.86E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.62|P-value:2.55E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.46|P-value:7.09E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:-3.52|P-value:5.92E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.58|P-value:4.83E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.24|P-value:9.06E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-5.78|P-value:3.85E-8 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.30|P-value:7.38E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.16|P-value:4.12E-7 ID:SGTC_1618|Compound:st003135|FD-Score:3.79|P-value:1.39E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.62|P-value:2.51E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.71|P-value:3.33E-6 ID:SGTC_1682|Compound:st012968|FD-Score:4.41|P-value:1.23E-5 ID:SGTC_1750|Compound:st081859|FD-Score:5.09|P-value:5.76E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.60|P-value:4.46E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.78|P-value:2.41E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.60|P-value:2.73E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.22|P-value:9.53E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.52|P-value:5.94E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.30|P-value:7.55E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.38|P-value:1.38E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.52|P-value:3.60E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.56|P-value:3.09E-4 ID:SGTC_2399|Compound:5884133|FD-Score:7.24|P-value:2.84E-12 ID:SGTC_2477|Compound:5967686|FD-Score:5.60|P-value:4.74E-8 ID:SGTC_2485|Compound:5633444|FD-Score:-4.93|P-value:2.47E-6 ID:SGTC_2486|Compound:5283202|FD-Score:-3.65|P-value:3.77E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:4.10|P-value:4.28E-5 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.50|P-value:3.88E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.37|P-value:5.88E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.40|P-value:8.61E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.54|P-value:3.32E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.94|P-value:7.44E-9 ID:SGTC_3310|Compound:9130229|FD-Score:-3.68|P-value:3.48E-4 ID:SGTC_3330|Compound:9141424|FD-Score:3.83|P-value:1.21E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-4.42|P-value:2.12E-5

Top fitness defect scores for YBR058C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2399 5884133 7.24 200.0 µM 2.84E-12 cell wall signaling 18 2.17E-13
2 SGTC_103 0844-0104 6.91 51.8 µM 2.53E-11 ERAD & cell cycle 61 2.49E-12
3 SGTC_568 1193-0097 6.70 7.5 µM 9.36E-11 ERAD & cell cycle 51 1.07E-11
4 SGTC_3142 9086498 5.94 49.5 µM 7.44E-9 iron homeostasis 7 1.40E-9
5 SGTC_2477 5967686 5.60 25.2 µM 4.74E-8 8 1.10E-8
6 SGTC_1604 st002052 5.16 72.4 µM 4.12E-7 TSC3-RPN4 10 1.21E-7
7 SGTC_1750 st081859 5.09 2.4 µM 5.76E-7 endomembrane recycling 135 1.75E-7
8 SGTC_159 3970-0959 5.02 50.0 µM 7.98E-7 42 2.52E-7
9 SGTC_1672 st016598 4.71 6.5 µM 3.33E-6 endomembrane recycling 49 1.23E-6
10 SGTC_66 0109-0187 4.45 42.4 µM 1.04E-5 27 4.32E-6
11 SGTC_1682 st012968 4.41 530.0 nM 1.23E-5 8 5.21E-6
12 SGTC_2347 9049783 4.38 174.8 µM 1.38E-5 13 5.90E-6
13 SGTC_2608 thymoquinone 4.10 42.7 µM 4.28E-5 14 2.07E-5
14 SGTC_745 0469-0705 3.99 296.0 µM 6.63E-5 mitochondrial processes 21 3.35E-5
15 SGTC_3330 9141424 3.83 71.4 µM 1.21E-4 amide catabolism 22 6.50E-5
16 SGTC_1618 st003135 3.79 44.5 µM 1.39E-4 25 7.56E-5
17 SGTC_1103 duloxetine 3.71 36.1 µM 1.86E-4 38 1.04E-4
18 SGTC_1664 st014217 3.62 9.0 µM 2.51E-4 60S ribosome export 17 1.46E-4
19 SGTC_1161 k007-0610 3.62 110.0 µM 2.55E-4 ERAD & cell cycle 137 1.48E-4
20 SGTC_2026 5148700 3.60 152.0 µM 2.73E-4 27 1.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 3.09E-40 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.217 3.44E-37 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.213 7.87E-36 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.195 5.71E-30 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.192 2.85E-29 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.190 1.39E-28 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.186 1.62E-27 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.179 1.15E-25 YPR153W YPR153W hom Putative protein of unknown function
0.177 3.78E-25 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.176 9.97E-25 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.166 5.00E-22 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.165 7.08E-22 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.155 2.07E-19 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.153 4.78E-19 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.151 1.33E-18 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm