HIPHOP chemogenomics database

YBR062C_p

Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR062C / YBR062C

Click on Significant Values for Screen Details

Top fitness defect scores for YBR062C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1989	st071868	5.65	50.2 µM	2.85E-10		1	7.83E-9
2	SGTC_1634	st006576	5.62	41.0 µM	3.65E-10	TSC3-RPN4	7	9.63E-9
3	SGTC_1979	st071809	5.31	45.3 µM	3.00E-9	RPP1 & pyrimidine depletion	3	5.57E-8
4	SGTC_2127	5253358	4.89	187.9 µM	4.27E-8		7	5.13E-7
5	SGTC_453	enantio-paf c16	4.80	10.0 µM	7.26E-8		96	7.99E-7
6	SGTC_1630	st005209	4.47	31.3 µM	4.83E-7		15	3.90E-6
7	SGTC_1723	st034307	4.19	2.5 µM	2.18E-6	mitochondrial processes	25	1.37E-5
8	SGTC_212	3807-4682	4.11	38.8 µM	3.37E-6	tubulin folding & SWR complex	62	1.98E-5
9	SGTC_662	k832-1615	3.89	104.0 µM	9.97E-6		18	4.91E-5
10	SGTC_834	0312-0008	3.82	75.7 µM	1.45E-5	NEO1	43	6.74E-5
11	SGTC_3211	9128781	3.79	49.5 µM	1.62E-5		67	7.40E-5
12	SGTC_862	0452-0056	3.53	10.2 µM	5.62E-5	azole & statin	42	2.10E-4
13	SGTC_1202	1988-0068	3.38	29.6 µM	1.07E-4	RNA processing & uracil transport	47	3.61E-4
14	SGTC_3058	9093861	3.26	49.5 µM	1.79E-4		44	5.55E-4
15	SGTC_1362	1611-0397	3.23	101.0 µM	2.04E-4		43	6.19E-4
16	SGTC_46	0329-0187a	3.22	2.2 µM	2.09E-4		111	6.32E-4
17	SGTC_2437	5741531	3.22	144.2 µM	2.14E-4		71	6.46E-4
18	SGTC_188	3229-0966	3.18	278.5 µM	2.46E-4		68	7.25E-4
19	SGTC_494	Boc-Gly-Val-Val-CHO	3.18	140.0 µM	2.48E-4		23	7.31E-4
20	SGTC_1717	st033143	3.13	58.0 µM	3.08E-4		87	8.77E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.168	1.40E-22	YER069W	ARG5,6	hom	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.127	1.38E-13	YMR195W	ICY1	hom	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.123	7.39E-13	YML101C-A_d	YML101C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111	1.01E-10	YBR232C_d	YBR232C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.108	3.57E-10	YBL034C	STU1	het	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.104	1.61E-9	YGR161W-C_p	YGR161W-C_p	hom	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.103	2.05E-9	YDL146W	LDB17	hom	Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
0.098	1.13E-8	YMR214W	SCJ1	hom	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.097	1.66E-8	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.097	1.95E-8	YOL140W	ARG8	hom	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.095	3.58E-8	YDL188C	PPH22	hom	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.093	7.16E-8	YLL020C_d	YLL020C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
0.092	1.08E-7	YLR298C	YHC1	het	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.091	1.34E-7	YBL005W	PDR3	hom	Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.091	1.39E-7	YLR042C_p	YLR042C_p	hom	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene