YBR063C_p

Putative protein of unknown function; YBR063C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR063C / YBR063C

Click on Significant Values for Screen Details ID:SGTC_195|Compound:4234-0266|FD-Score:3.29|P-value:2.19E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.10|P-value:4.57E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:2.99|P-value:6.92E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.10|P-value:4.60E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-2.96|P-value:7.86E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.37|P-value:1.60E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.13|P-value:4.14E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:2.99|P-value:7.13E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:2.94|P-value:8.32E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-2.99|P-value:7.12E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.27|P-value:2.37E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.23|P-value:2.86E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.48|P-value:1.01E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.01|P-value:9.18E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.25|P-value:2.62E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.90|P-value:9.95E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.06|P-value:5.37E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.25|P-value:2.64E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.02|P-value:6.40E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.41|P-value:1.37E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.94|P-value:8.57E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.17|P-value:3.57E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.75|P-value:1.93E-7 ID:SGTC_2055|Compound:5235184|FD-Score:2.90|P-value:9.76E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.00|P-value:9.51E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.84|P-value:2.03E-5 ID:SGTC_2442|Compound:5158906|FD-Score:2.99|P-value:7.01E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-2.92|P-value:9.12E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.96|P-value:7.80E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.22|P-value:2.98E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.20|P-value:3.64E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.32|P-value:1.94E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.02|P-value:6.19E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.04|P-value:5.89E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.90|P-value:1.59E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.11|P-value:4.51E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.28|P-value:2.26E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.14|P-value:2.07E-8 ID:SGTC_195|Compound:4234-0266|FD-Score:3.29|P-value:2.19E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.10|P-value:4.57E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:2.99|P-value:6.92E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.10|P-value:4.60E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-2.96|P-value:7.86E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.37|P-value:1.60E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.13|P-value:4.14E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:2.99|P-value:7.13E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:2.94|P-value:8.32E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-2.99|P-value:7.12E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.27|P-value:2.37E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:-3.23|P-value:2.86E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.48|P-value:1.01E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.01|P-value:9.18E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.25|P-value:2.62E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.90|P-value:9.95E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.06|P-value:5.37E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.25|P-value:2.64E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.02|P-value:6.40E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.41|P-value:1.37E-4 ID:SGTC_1861|Compound:st057647|FD-Score:2.94|P-value:8.57E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.17|P-value:3.57E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.75|P-value:1.93E-7 ID:SGTC_2055|Compound:5235184|FD-Score:2.90|P-value:9.76E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.00|P-value:9.51E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.84|P-value:2.03E-5 ID:SGTC_2442|Compound:5158906|FD-Score:2.99|P-value:7.01E-4 ID:SGTC_2443|Compound:5493264|FD-Score:-2.92|P-value:9.12E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.96|P-value:7.80E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.22|P-value:2.98E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.20|P-value:3.64E-6 ID:SGTC_2877|Compound:9040724|FD-Score:3.32|P-value:1.94E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.02|P-value:6.19E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.04|P-value:5.89E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.90|P-value:1.59E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.11|P-value:4.51E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.28|P-value:2.26E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.46|P-value:1.09E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.14|P-value:2.07E-8

Top fitness defect scores for YBR063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3334 9142812 5.14 21.9 µM 2.07E-8 11 1.40E-7
2 SGTC_2050 5263056 4.75 171.0 µM 1.93E-7 fatty acid desaturase (OLE1) 28 1.00E-6
3 SGTC_2844 9010103 4.20 26.0 µM 3.64E-6 27 1.34E-5
4 SGTC_2060 5238662 4.00 140.0 µM 9.51E-6 27 3.11E-5
5 SGTC_3217 9129673 3.90 49.5 µM 1.59E-5 41 4.89E-5
6 SGTC_2326 6164455 3.84 177.6 µM 2.03E-5 mitochondrial processes 25 6.08E-5
7 SGTC_1225 1216-0074 3.48 20.6 µM 1.01E-4 39 2.51E-4
8 SGTC_3333 9141820 3.46 12.1 µM 1.09E-4 22 2.69E-4
9 SGTC_1854 st056233 3.41 32.9 µM 1.37E-4 amide catabolism 33 3.29E-4
10 SGTC_541 4513-1321 3.37 94.0 µM 1.60E-4 36 3.77E-4
11 SGTC_2877 9040724 3.32 71.4 µM 1.94E-4 35 4.47E-4
12 SGTC_195 4234-0266 3.29 16.6 µM 2.19E-4 66 4.97E-4
13 SGTC_3326 9140064 3.28 16.4 µM 2.26E-4 36 5.10E-4
14 SGTC_1060 3448-7350 3.27 82.0 µM 2.37E-4 Golgi 57 5.33E-4
15 SGTC_1317 1273-0028 3.25 910.0 nM 2.62E-4 azole & statin 79 5.81E-4
16 SGTC_1548 st061468 3.25 90.8 µM 2.64E-4 24 5.86E-4
17 SGTC_2602 kawain 3.22 100.0 µM 2.98E-4 64 6.52E-4
18 SGTC_607 4491-0986 3.13 66.8 µM 4.14E-4 heme requiring 52 8.73E-4
19 SGTC_3083 9117465 3.12 49.5 µM 4.29E-4 62 9.00E-4
20 SGTC_3323 9138564 3.11 53.9 µM 4.51E-4 52 9.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.71E-14 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.114 3.97E-11 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.111 1.02E-10 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.102 2.62E-9 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.102 3.84E-9 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.092 8.30E-8 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.088 2.99E-7 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.088 2.97E-7 YIL066C RNR3 hom Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
0.087 4.55E-7 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.083 1.31E-6 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.083 1.38E-6 YMR301C ATM1 het Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
0.080 3.43E-6 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.077 8.08E-6 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.077 8.84E-6 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.075 1.29E-5 YHR152W SPO12 hom Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis