YBR068C / BAP2

High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR068C / BAP2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:12.80|P-value:3.62E-43 ID:SGTC_8|Compound:0354-0001|FD-Score:7.33|P-value:2.05E-15 ID:SGTC_12|Compound:0849-0099|FD-Score:4.91|P-value:7.38E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:16.10|P-value:1.62E-67 ID:SGTC_21|Compound:0849-0113|FD-Score:5.53|P-value:1.54E-9 ID:SGTC_31|Compound:0508-1974|FD-Score:5.49|P-value:2.00E-9 ID:SGTC_34|Compound:0469-0683|FD-Score:10.70|P-value:9.77E-31 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.06|P-value:6.81E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:7.43|P-value:8.08E-16 ID:SGTC_59|Compound:0330-0160|FD-Score:19.20|P-value:6.50E-95 ID:SGTC_84|Compound:0443-0269|FD-Score:5.97|P-value:7.82E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:4.20|P-value:3.47E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.42|P-value:1.09E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:3.98|P-value:1.04E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:16.90|P-value:3.56E-74 ID:SGTC_195|Compound:4234-0266|FD-Score:5.82|P-value:2.23E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:5.61|P-value:9.55E-10 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.30|P-value:2.11E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:6.43|P-value:2.69E-12 ID:SGTC_384|Compound:k007-0144|FD-Score:3.74|P-value:3.15E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.86|P-value:9.87E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.18|P-value:3.08E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.41|P-value:1.19E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.76|P-value:2.83E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.06|P-value:5.44E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.51|P-value:8.55E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.00|P-value:6.13E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.48|P-value:9.85E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.13|P-value:4.16E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.18|P-value:3.89E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.57|P-value:6.80E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:23.30|P-value:3.77E-138 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.16|P-value:3.31E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:2.97|P-value:7.49E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.75|P-value:3.06E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.25|P-value:2.58E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.58|P-value:6.48E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.29|P-value:2.18E-6 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.72|P-value:3.42E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.28|P-value:2.05E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:-4.02|P-value:7.24E-6 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.16|P-value:3.62E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1605|Compound:st000082|FD-Score:2.89|P-value:9.98E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.13|P-value:4.03E-4 ID:SGTC_1656|Compound:st012921|FD-Score:14.40|P-value:7.37E-54 ID:SGTC_1699|Compound:st031318|FD-Score:2.90|P-value:9.76E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.46|P-value:9.50E-5 ID:SGTC_2132|Compound:5317594|FD-Score:11.10|P-value:2.96E-33 ID:SGTC_2258|Compound:7960471|FD-Score:3.17|P-value:3.52E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.64|P-value:3.45E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.14|P-value:3.90E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.07|P-value:5.14E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.18|P-value:3.05E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.46|P-value:9.55E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.51|P-value:8.53E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.81|P-value:2.28E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.95|P-value:7.27E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.10|P-value:3.34E-33 ID:SGTC_2696|Compound:st077691|FD-Score:3.31|P-value:1.99E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.14|P-value:3.51E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.41|P-value:1.34E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.22|P-value:1.16E-8 ID:SGTC_2938|Compound:9059746|FD-Score:3.61|P-value:5.69E-5 ID:SGTC_2976|Compound:9009005|FD-Score:19.10|P-value:4.13E-94 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.43|P-value:1.03E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.55|P-value:5.69E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.36|P-value:1.56E-6 ID:SGTC_3245|Compound:9134821|FD-Score:-3.46|P-value:9.51E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-5.80|P-value:2.14E-10 ID:SGTC_3291|Compound:9121177|FD-Score:-3.57|P-value:5.96E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.18|P-value:3.02E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.82|P-value:1.88E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.10|P-value:4.16E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:12.80|P-value:3.62E-43 ID:SGTC_8|Compound:0354-0001|FD-Score:7.33|P-value:2.05E-15 ID:SGTC_12|Compound:0849-0099|FD-Score:4.91|P-value:7.38E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:16.10|P-value:1.62E-67 ID:SGTC_21|Compound:0849-0113|FD-Score:5.53|P-value:1.54E-9 ID:SGTC_31|Compound:0508-1974|FD-Score:5.49|P-value:2.00E-9 ID:SGTC_34|Compound:0469-0683|FD-Score:10.70|P-value:9.77E-31 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.06|P-value:6.81E-6 ID:SGTC_55|Compound:0767-0285|FD-Score:7.43|P-value:8.08E-16 ID:SGTC_59|Compound:0330-0160|FD-Score:19.20|P-value:6.50E-95 ID:SGTC_84|Compound:0443-0269|FD-Score:5.97|P-value:7.82E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:4.20|P-value:3.47E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:4.42|P-value:1.09E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:3.98|P-value:1.04E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:16.90|P-value:3.56E-74 ID:SGTC_195|Compound:4234-0266|FD-Score:5.82|P-value:2.23E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:5.61|P-value:9.55E-10 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.30|P-value:2.11E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:6.43|P-value:2.69E-12 ID:SGTC_384|Compound:k007-0144|FD-Score:3.74|P-value:3.15E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.86|P-value:9.87E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.18|P-value:3.08E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.41|P-value:1.19E-6 ID:SGTC_657|Compound:3534-0529|FD-Score:3.76|P-value:2.83E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:3.06|P-value:5.44E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.51|P-value:8.55E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.00|P-value:6.13E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.48|P-value:9.85E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.13|P-value:4.16E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.18|P-value:3.89E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.57|P-value:6.80E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:23.30|P-value:3.77E-138 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.16|P-value:3.31E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:2.97|P-value:7.49E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.75|P-value:3.06E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.25|P-value:2.58E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.58|P-value:6.48E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.29|P-value:2.18E-6 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.72|P-value:3.42E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.28|P-value:2.05E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:-4.02|P-value:7.24E-6 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.16|P-value:3.62E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.09|P-value:4.69E-4 ID:SGTC_1605|Compound:st000082|FD-Score:2.89|P-value:9.98E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.13|P-value:4.03E-4 ID:SGTC_1656|Compound:st012921|FD-Score:14.40|P-value:7.37E-54 ID:SGTC_1699|Compound:st031318|FD-Score:2.90|P-value:9.76E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.47|P-value:1.01E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.46|P-value:9.50E-5 ID:SGTC_2132|Compound:5317594|FD-Score:11.10|P-value:2.96E-33 ID:SGTC_2258|Compound:7960471|FD-Score:3.17|P-value:3.52E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.64|P-value:3.45E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.14|P-value:3.90E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.07|P-value:5.14E-4 ID:SGTC_2365|Compound:9042475|FD-Score:-3.18|P-value:3.05E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.46|P-value:9.55E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.51|P-value:8.53E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.81|P-value:2.28E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.95|P-value:7.27E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.10|P-value:3.34E-33 ID:SGTC_2696|Compound:st077691|FD-Score:3.31|P-value:1.99E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.46|P-value:1.07E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.14|P-value:3.51E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.41|P-value:1.34E-4 ID:SGTC_2932|Compound:9016711|FD-Score:5.22|P-value:1.16E-8 ID:SGTC_2938|Compound:9059746|FD-Score:3.61|P-value:5.69E-5 ID:SGTC_2976|Compound:9009005|FD-Score:19.10|P-value:4.13E-94 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.43|P-value:1.03E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:4.55|P-value:5.69E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.36|P-value:1.56E-6 ID:SGTC_3245|Compound:9134821|FD-Score:-3.46|P-value:9.51E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-5.80|P-value:2.14E-10 ID:SGTC_3291|Compound:9121177|FD-Score:-3.57|P-value:5.96E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.18|P-value:3.02E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.82|P-value:1.88E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.10|P-value:4.16E-4

Top fitness defect scores for YBR068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1226 3909-7979 23.30 35.4 µM 3.77E-138 2 2.99E-120
2 SGTC_59 0330-0160 19.20 1.3 µM 6.50E-95 3 1.02E-82
3 SGTC_2976 9009005 19.10 19.5 µM 4.13E-94 2 5.05E-82
4 SGTC_163 1327-0036 16.90 7.5 µM 3.56E-74 5 1.03E-64
5 SGTC_18 0111-0177 16.10 500.0 nM 1.62E-67 1 6.21E-59
6 SGTC_1656 st012921 14.40 11.0 µM 7.37E-54 4 4.53E-47
7 SGTC_7 0192-1582 12.80 4.2 µM 3.62E-43 5 8.78E-38
8 SGTC_2132 5317594 11.10 122.7 µM 2.96E-33 SWF1 & branched chain AA biosynthesis 3 3.61E-29
9 SGTC_2651 1327-0036 11.10 5.0 µM 3.34E-33 18 4.01E-29
10 SGTC_34 0469-0683 10.70 81.8 µM 9.77E-31 SWF1 & branched chain AA biosynthesis 3 5.58E-27
11 SGTC_55 0767-0285 7.43 6.6 µM 8.08E-16 11 5.28E-14
12 SGTC_8 0354-0001 7.33 70.0 µM 2.05E-15 16 1.19E-13
13 SGTC_315 k915-0449 6.43 187.0 µM 2.69E-12 17 6.17E-11
14 SGTC_84 0443-0269 5.97 128.8 µM 7.82E-11 3 1.17E-9
15 SGTC_195 4234-0266 5.82 16.6 µM 2.23E-10 9 2.91E-9
16 SGTC_236 1509-0011 5.61 5.3 µM 9.55E-10 301 1.04E-8
17 SGTC_21 0849-0113 5.53 23.0 µM 1.54E-9 11 1.57E-8
18 SGTC_31 0508-1974 5.49 57.2 µM 2.00E-9 5 1.98E-8
19 SGTC_2932 9016711 5.22 44.5 µM 1.16E-8 21 9.15E-8
20 SGTC_12 0849-0099 4.91 9.3 µM 7.38E-8 11 4.60E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.422 1.07E-144 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.409 1.07E-135 YPR060C ARO7 hom Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
0.382 1.02E-116 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.273 1.42E-58 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.258 3.75E-52 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.256 3.12E-51 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.254 1.26E-50 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.250 6.30E-49 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.248 2.99E-48 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.244 1.49E-46 YHL011C PRS3 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.243 3.89E-46 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.242 5.13E-46 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.236 1.10E-43 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.236 1.49E-43 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.234 5.24E-43 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion