YBR083W / TEC1

Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR083W / TEC1

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:-2.72|P-value:7.85E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.67|P-value:9.48E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-2.90|P-value:3.65E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-2.82|P-value:5.21E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.74|P-value:6.99E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.25|P-value:3.64E-7 ID:SGTC_843|Compound:0310-0051|FD-Score:-2.72|P-value:7.65E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-2.94|P-value:3.06E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-2.79|P-value:5.93E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.62|P-value:1.23E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:2.69|P-value:8.47E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.56|P-value:1.66E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.12|P-value:1.43E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.42|P-value:3.37E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:2.70|P-value:8.10E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:2.83|P-value:4.73E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.20|P-value:6.76E-10 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:2.78|P-value:5.83E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-2.82|P-value:5.22E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.29|P-value:6.29E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.10|P-value:1.52E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.78|P-value:6.09E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-2.80|P-value:5.57E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.03|P-value:1.38E-6 ID:SGTC_1638|Compound:st008370|FD-Score:-3.66|P-value:9.97E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-2.81|P-value:5.44E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.30|P-value:2.67E-7 ID:SGTC_1911|Compound:st060208|FD-Score:-2.99|P-value:2.52E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.88|P-value:3.95E-4 ID:SGTC_2175|Compound:5807670|FD-Score:2.98|P-value:2.58E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.85|P-value:4.49E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.00|P-value:2.38E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.15|P-value:1.21E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.30|P-value:6.01E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-2.75|P-value:6.85E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.08|P-value:1.63E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.41|P-value:3.52E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.22|P-value:8.51E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.67|P-value:9.78E-6 ID:SGTC_2923|Compound:7992654|FD-Score:-4.55|P-value:5.83E-8 ID:SGTC_2992|Compound:9074591|FD-Score:-2.90|P-value:3.74E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.93|P-value:3.10E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.72|P-value:7.85E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.67|P-value:9.48E-6 ID:SGTC_398|Compound:bronopol|FD-Score:-2.90|P-value:3.65E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-2.82|P-value:5.21E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.74|P-value:6.99E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.25|P-value:3.64E-7 ID:SGTC_843|Compound:0310-0051|FD-Score:-2.72|P-value:7.65E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-2.94|P-value:3.06E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-2.79|P-value:5.93E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.62|P-value:1.23E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:2.69|P-value:8.47E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.56|P-value:1.66E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.12|P-value:1.43E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.42|P-value:3.37E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:2.70|P-value:8.10E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:2.83|P-value:4.73E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.20|P-value:6.76E-10 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:2.78|P-value:5.83E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-2.82|P-value:5.22E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.29|P-value:6.29E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.10|P-value:1.52E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.78|P-value:6.09E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-2.80|P-value:5.57E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.03|P-value:1.38E-6 ID:SGTC_1638|Compound:st008370|FD-Score:-3.66|P-value:9.97E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-2.81|P-value:5.44E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.30|P-value:2.67E-7 ID:SGTC_1911|Compound:st060208|FD-Score:-2.99|P-value:2.52E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.88|P-value:3.95E-4 ID:SGTC_2175|Compound:5807670|FD-Score:2.98|P-value:2.58E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.85|P-value:4.49E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.00|P-value:2.38E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.15|P-value:1.21E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.30|P-value:6.01E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-2.75|P-value:6.85E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.08|P-value:1.63E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.41|P-value:3.52E-5 ID:SGTC_2602|Compound:kawain|FD-Score:3.22|P-value:8.51E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.67|P-value:9.78E-6 ID:SGTC_2923|Compound:7992654|FD-Score:-4.55|P-value:5.83E-8 ID:SGTC_2992|Compound:9074591|FD-Score:-2.90|P-value:3.74E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.93|P-value:3.10E-4

Top fitness defect scores for YBR083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1734 st037168 4.30 69.4 µM 2.67E-7 15 8.57E-6
2 SGTC_669 0108-0021 4.25 26.2 µM 3.64E-7 fatty acid desaturase (OLE1) 67 1.08E-5
3 SGTC_142 0335-0849 3.67 62.7 µM 9.48E-6 ubiquinone biosynthesis & proteasome 145 1.23E-4
4 SGTC_986 1493-0483 3.62 84.0 µM 1.23E-5 20 1.49E-4
5 SGTC_996 3970-0799 3.56 1.8 µM 1.66E-5 109 1.86E-4
6 SGTC_1058 3448-5425 3.42 97.3 µM 3.37E-5 44 3.17E-4
7 SGTC_2594 a-mangostin 3.41 100.0 µM 3.52E-5 52 3.27E-4
8 SGTC_2346 9031566 3.30 143.8 µM 6.01E-5 Golgi 49 4.89E-4
9 SGTC_1179 1021-1431 3.29 9.3 µM 6.29E-5 74 5.05E-4
10 SGTC_2602 kawain 3.22 100.0 µM 8.51E-5 62 6.34E-4
11 SGTC_2341 7987486 3.15 176.7 µM 1.21E-4 47 8.24E-4
12 SGTC_1184 1269-1718 3.10 139.0 µM 1.52E-4 62 9.79E-4
13 SGTC_2435 5706476 3.08 10.6 µM 1.63E-4 61 0.00103
14 SGTC_2309 7664088 3.00 163.9 µM 2.38E-4 105 0.00137
15 SGTC_2175 5807670 2.98 165.3 µM 2.58E-4 62 0.00146
16 SGTC_3336 9143619 2.93 71.4 µM 3.10E-4 57 0.00167
17 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 2.83 15.5 µM 4.73E-4 81 0.00230
18 SGTC_1116 jasmonic acid 2.78 1.6 µM 5.83E-4 80 0.00269
19 SGTC_1060 3448-7350 2.70 82.0 µM 8.10E-4 Golgi 88 0.00345
20 SGTC_987 1497-1013 2.69 404.0 µM 8.47E-4 67 0.00357

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.306 1.85E-73 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.241 1.60E-45 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.222 9.97E-39 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.207 6.34E-34 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.207 1.24E-33 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.206 1.50E-33 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.199 2.98E-31 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.192 3.15E-29 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.190 1.18E-28 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.189 1.79E-28 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.186 1.49E-27 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.185 4.04E-27 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.183 1.32E-26 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.182 1.98E-26 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.178 2.31E-25 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport