YBR084C-A / RPL19A

Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR084C-A / RPL19A

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:-4.08|P-value:9.74E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:-4.75|P-value:6.63E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.82|P-value:4.95E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:5.33|P-value:2.01E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.53|P-value:6.46E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.66|P-value:9.83E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:4.19|P-value:3.19E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.25|P-value:8.92E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.96|P-value:7.60E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:-3.67|P-value:4.10E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.46|P-value:4.60E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-4.55|P-value:1.52E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.37|P-value:6.17E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.43|P-value:4.99E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.23|P-value:5.45E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:4.13|P-value:4.01E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.89|P-value:3.62E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.57|P-value:1.44E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.23|P-value:9.51E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.02|P-value:6.10E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.28|P-value:8.18E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.74|P-value:1.71E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.31|P-value:7.46E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.36|P-value:1.78E-7 ID:SGTC_1618|Compound:st003135|FD-Score:-3.54|P-value:6.39E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.27|P-value:8.35E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.58|P-value:5.54E-4 ID:SGTC_1868|Compound:st057644|FD-Score:5.73|P-value:2.72E-8 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:7.31|P-value:2.35E-12 ID:SGTC_1871|Compound:st057448|FD-Score:4.70|P-value:3.74E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-5.68|P-value:8.85E-8 ID:SGTC_1910|Compound:st062352|FD-Score:3.42|P-value:5.20E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.83|P-value:2.17E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.46|P-value:4.60E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.55|P-value:3.32E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.28|P-value:8.23E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.31|P-value:1.93E-5 ID:SGTC_2487|Compound:5918373|FD-Score:-3.68|P-value:3.93E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.38|P-value:1.50E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.83|P-value:2.38E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-5.52|P-value:1.96E-7 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.33|P-value:6.93E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.47|P-value:4.37E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.50|P-value:3.95E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.24|P-value:7.48E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.11|P-value:5.98E-7 ID:SGTC_2804|Compound:7954240|FD-Score:6.95|P-value:2.39E-11 ID:SGTC_2805|Compound:7950783|FD-Score:-5.86|P-value:3.51E-8 ID:SGTC_2814|Compound:7977482|FD-Score:-3.54|P-value:6.23E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.25|P-value:8.98E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.44|P-value:8.82E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.59|P-value:5.41E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.60|P-value:2.80E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.34|P-value:1.76E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.38|P-value:5.85E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.32|P-value:3.83E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.76|P-value:2.29E-10 ID:SGTC_3348|Compound:9149464|FD-Score:3.25|P-value:8.90E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.27|P-value:2.27E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.08|P-value:9.74E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:-4.75|P-value:6.63E-6 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.82|P-value:4.95E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:5.33|P-value:2.01E-7 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.53|P-value:6.46E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.66|P-value:9.83E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:4.19|P-value:3.19E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:3.25|P-value:8.92E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.96|P-value:7.60E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:-3.67|P-value:4.10E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.46|P-value:4.60E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-4.55|P-value:1.52E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.37|P-value:6.17E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.43|P-value:4.99E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.23|P-value:5.45E-5 ID:SGTC_873|Compound:0591-4978|FD-Score:4.13|P-value:4.01E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.89|P-value:3.62E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.57|P-value:1.44E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.23|P-value:9.51E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.02|P-value:6.10E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.28|P-value:8.18E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.74|P-value:1.71E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.31|P-value:7.46E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.36|P-value:1.78E-7 ID:SGTC_1618|Compound:st003135|FD-Score:-3.54|P-value:6.39E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.27|P-value:8.35E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.58|P-value:5.54E-4 ID:SGTC_1868|Compound:st057644|FD-Score:5.73|P-value:2.72E-8 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:7.31|P-value:2.35E-12 ID:SGTC_1871|Compound:st057448|FD-Score:4.70|P-value:3.74E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:3.55|P-value:3.33E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-5.68|P-value:8.85E-8 ID:SGTC_1910|Compound:st062352|FD-Score:3.42|P-value:5.20E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.83|P-value:2.17E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.46|P-value:4.60E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.55|P-value:3.32E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.28|P-value:8.23E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.31|P-value:1.93E-5 ID:SGTC_2487|Compound:5918373|FD-Score:-3.68|P-value:3.93E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.38|P-value:1.50E-5 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.83|P-value:2.38E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-5.52|P-value:1.96E-7 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.33|P-value:6.93E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.47|P-value:4.37E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.50|P-value:3.95E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.24|P-value:7.48E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.11|P-value:5.98E-7 ID:SGTC_2804|Compound:7954240|FD-Score:6.95|P-value:2.39E-11 ID:SGTC_2805|Compound:7950783|FD-Score:-5.86|P-value:3.51E-8 ID:SGTC_2814|Compound:7977482|FD-Score:-3.54|P-value:6.23E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.25|P-value:8.98E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.44|P-value:8.82E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.59|P-value:5.41E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.60|P-value:2.80E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.63|P-value:2.57E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.34|P-value:1.76E-5 ID:SGTC_3002|Compound:9075603|FD-Score:3.38|P-value:5.85E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.32|P-value:3.83E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-6.76|P-value:2.29E-10 ID:SGTC_3348|Compound:9149464|FD-Score:3.25|P-value:8.90E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.27|P-value:2.27E-5

Top fitness defect scores for YBR084C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1869 3',7'-dimethoxyflavone 7.31 40.3 µM 2.35E-12 1 1.34E-13
2 SGTC_2804 7954240 6.95 19.5 µM 2.39E-11 2 1.84E-12
3 SGTC_1868 st057644 5.73 42.7 µM 2.72E-8 11 5.08E-9
4 SGTC_1528 arabinosylhypoxanthine 5.36 74.6 µM 1.78E-7 6 4.19E-8
5 SGTC_212 3807-4682 5.33 38.8 µM 2.01E-7 tubulin folding & SWR complex 34 4.82E-8
6 SGTC_2688 kanamycin b 5.11 96.7 µM 5.98E-7 calcium & mitochondrial duress 235 1.63E-7
7 SGTC_2035 5154463 4.83 94.6 µM 2.17E-6 5 6.92E-7
8 SGTC_1871 st057448 4.70 67.3 µM 3.74E-6 10 1.28E-6
9 SGTC_2512 diallyl trisulfide 4.38 49.2 µM 1.50E-5 3 6.02E-6
10 SGTC_2952 9073731 4.34 13.8 µM 1.76E-5 tubulin folding & SWR complex 28 7.19E-6
11 SGTC_2483 5729050 4.31 27.2 µM 1.93E-5 15 8.00E-6
12 SGTC_3351 9150312 4.27 21.6 µM 2.27E-5 cell wall 30 9.58E-6
13 SGTC_341 1486-1430 4.19 230.0 µM 3.19E-5 19 1.40E-5
14 SGTC_873 0591-4978 4.13 488.0 µM 4.01E-5 18 1.81E-5
15 SGTC_1146 3579-1023 4.02 7.0 µM 6.10E-5 14 2.89E-5
16 SGTC_549 1661-1316 3.96 519.0 µM 7.60E-5 17 3.69E-5
17 SGTC_1362 1611-0397 3.74 101.0 µM 1.71E-4 24 9.12E-5
18 SGTC_2926 9010726 3.63 65.2 µM 2.57E-4 42 1.43E-4
19 SGTC_2922 7999257 3.60 32.5 µM 2.80E-4 16 1.57E-4
20 SGTC_2246 7293507 3.55 91.6 µM 3.32E-4 38 1.90E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.23E-16 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.132 2.07E-14 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.129 6.94E-14 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.119 6.06E-12 YPR038W_d IRC16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
0.117 9.98E-12 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.115 3.03E-11 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.113 5.25E-11 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.110 1.77E-10 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.105 1.28E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.104 1.45E-9 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.103 2.68E-9 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.100 6.45E-9 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.100 7.64E-9 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.095 4.51E-8 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.094 4.85E-8 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters