HIPHOP chemogenomics database

YBR084C-A / RPL19A

Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR084C-A / RPL19A

Click on Significant Values for Screen Details

Top fitness defect scores for YBR084C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1869	3',7'-dimethoxyflavone	7.31	40.3 µM	2.35E-12		1	1.34E-13
2	SGTC_2804	7954240	6.95	19.5 µM	2.39E-11		2	1.84E-12
3	SGTC_1868	st057644	5.73	42.7 µM	2.72E-8		11	5.08E-9
4	SGTC_1528	arabinosylhypoxanthine	5.36	74.6 µM	1.78E-7		6	4.19E-8
5	SGTC_212	3807-4682	5.33	38.8 µM	2.01E-7	tubulin folding & SWR complex	34	4.82E-8
6	SGTC_2688	kanamycin b	5.11	96.7 µM	5.98E-7	calcium & mitochondrial duress	235	1.63E-7
7	SGTC_2035	5154463	4.83	94.6 µM	2.17E-6		5	6.92E-7
8	SGTC_1871	st057448	4.70	67.3 µM	3.74E-6		10	1.28E-6
9	SGTC_2512	diallyl trisulfide	4.38	49.2 µM	1.50E-5		3	6.02E-6
10	SGTC_2952	9073731	4.34	13.8 µM	1.76E-5	tubulin folding & SWR complex	28	7.19E-6
11	SGTC_2483	5729050	4.31	27.2 µM	1.93E-5		15	8.00E-6
12	SGTC_3351	9150312	4.27	21.6 µM	2.27E-5	cell wall	30	9.58E-6
13	SGTC_341	1486-1430	4.19	230.0 µM	3.19E-5		19	1.40E-5
14	SGTC_873	0591-4978	4.13	488.0 µM	4.01E-5		18	1.81E-5
15	SGTC_1146	3579-1023	4.02	7.0 µM	6.10E-5		14	2.89E-5
16	SGTC_549	1661-1316	3.96	519.0 µM	7.60E-5		17	3.69E-5
17	SGTC_1362	1611-0397	3.74	101.0 µM	1.71E-4		24	9.12E-5
18	SGTC_2926	9010726	3.63	65.2 µM	2.57E-4		42	1.43E-4
19	SGTC_2922	7999257	3.60	32.5 µM	2.80E-4		16	1.57E-4
20	SGTC_2246	7293507	3.55	91.6 µM	3.32E-4		38	1.90E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.141	2.23E-16	YDR417C_d	YDR417C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.132	2.07E-14	YOR234C	RPL33B	hom	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.129	6.94E-14	YDL082W	RPL13A	hom	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.119	6.06E-12	YPR038W_d	IRC16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
0.117	9.98E-12	YNL067W	RPL9B	hom	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.115	3.03E-11	YFR031C-A	RPL2A	hom	Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.113	5.25E-11	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.110	1.77E-10	YGR085C	RPL11B	hom	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.105	1.28E-9	YBL034C	STU1	het	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.104	1.45E-9	YLL045C	RPL8B	hom	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.103	2.68E-9	YPL125W	KAP120	hom	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.100	6.45E-9	YHL033C	RPL8A	hom	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.100	7.64E-9	YML019W	OST6	hom	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.095	4.51E-8	YGR212W	SLI1	hom	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.094	4.85E-8	YIL088C	AVT7	hom	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters