YBR089C-A / NHP6B

High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR089C-A / NHP6B

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-2.90|P-value:7.93E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.17|P-value:2.23E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.84|P-value:1.06E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.19|P-value:2.07E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.05|P-value:3.68E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.30|P-value:1.28E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.25|P-value:1.30E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:3.98|P-value:5.40E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.14|P-value:2.35E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.76|P-value:1.60E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.33|P-value:1.12E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.04|P-value:3.72E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.07|P-value:3.43E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.91|P-value:7.69E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.09|P-value:3.10E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.19|P-value:2.46E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.74|P-value:8.06E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.80|P-value:9.50E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.11|P-value:3.49E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:2.95|P-value:5.46E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.11|P-value:3.52E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.37|P-value:9.53E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.15|P-value:2.39E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.96|P-value:5.10E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.84|P-value:1.09E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.09|P-value:3.07E-4 ID:SGTC_2156|Compound:5649887|FD-Score:2.83|P-value:8.43E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.50|P-value:5.24E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.07|P-value:4.02E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.81|P-value:9.09E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.71|P-value:1.97E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-4.38|P-value:8.27E-7 ID:SGTC_21|Compound:0849-0113|FD-Score:-2.90|P-value:7.93E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.17|P-value:2.23E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.84|P-value:1.06E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.19|P-value:2.07E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.05|P-value:3.68E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.30|P-value:1.28E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.25|P-value:1.30E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:3.98|P-value:5.40E-6 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.14|P-value:2.35E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.76|P-value:1.60E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.33|P-value:1.12E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.04|P-value:3.72E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.07|P-value:3.43E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.25|P-value:1.57E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.91|P-value:7.69E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.09|P-value:3.10E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:-3.19|P-value:2.46E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.74|P-value:8.06E-8 ID:SGTC_1370|Compound:2001-0092|FD-Score:2.80|P-value:9.50E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.11|P-value:3.49E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:2.95|P-value:5.46E-4 ID:SGTC_1757|Compound:st041620|FD-Score:-4.11|P-value:3.52E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.37|P-value:9.53E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.15|P-value:2.39E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.96|P-value:5.10E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.84|P-value:1.09E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.09|P-value:3.07E-4 ID:SGTC_2156|Compound:5649887|FD-Score:2.83|P-value:8.43E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.50|P-value:5.24E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.07|P-value:4.02E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.81|P-value:9.09E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.71|P-value:1.97E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-4.38|P-value:8.27E-7

Top fitness defect scores for YBR089C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1336 1486-0901 4.74 104.0 µM 8.06E-8 13 1.06E-6
2 SGTC_1061 3448-9325 4.25 110.0 µM 1.30E-6 19 1.07E-5
3 SGTC_1069 diphenylcyclopropenone 4.14 8.5 µM 2.35E-6 29 1.74E-5
4 SGTC_1170 0310-0127 4.07 64.8 µM 3.43E-6 23 2.38E-5
5 SGTC_1064 honokiol 3.98 6.8 µM 5.40E-6 23 3.47E-5
6 SGTC_1203 3992-3522 3.91 103.0 µM 7.69E-6 36 4.65E-5
7 SGTC_69 0096-0274 3.84 206.7 µM 1.06E-5 mitochondrial processes 46 6.07E-5
8 SGTC_1935 st074532 3.84 41.6 µM 1.09E-5 34 6.22E-5
9 SGTC_1072 oxiconazole 3.76 14.9 nM 1.60E-5 ergosterol depletion effects on membrane 59 8.56E-5
10 SGTC_2983 9022671 3.71 13.0 µM 1.97E-5 60S ribosome export 15 1.02E-4
11 SGTC_2350 9023895 3.50 38.9 µM 5.24E-5 ergosterol biosynthesis 45 2.29E-4
12 SGTC_1917 st066507 3.37 28.5 µM 9.53E-5 Golgi 71 3.76E-4
13 SGTC_1164 k060-0068 3.33 93.7 µM 1.12E-4 55 4.31E-4
14 SGTC_919 tnp00227 3.30 403.6 nM 1.28E-4 RNA pol III & RNase P/MRP 71 4.81E-4
15 SGTC_1178 0988-0033 3.25 191.0 µM 1.57E-4 57 5.69E-4
16 SGTC_77 0828-0286 3.19 12.5 µM 2.07E-4 TSC3-RPN4 72 7.17E-4
17 SGTC_65 0798-0905 3.17 35.0 µM 2.23E-4 calcium & mitochondrial duress 144 7.64E-4
18 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.15 70.1 µM 2.39E-4 71 8.09E-4
19 SGTC_2117 5521686 3.09 200.0 µM 3.07E-4 50 9.96E-4
20 SGTC_1216 1165-0504 3.09 9.7 µM 3.10E-4 46 0.00100

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.67E-20 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.123 1.01E-12 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.111 1.32E-10 YAR047C_d YAR047C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.104 1.82E-9 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.102 3.27E-9 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.101 4.70E-9 YLR006C SSK1 hom Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
0.096 2.76E-8 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
0.095 3.66E-8 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.093 6.97E-8 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.093 7.47E-8 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.28E-7 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.089 2.38E-7 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.088 3.21E-7 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.086 6.42E-7 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.086 6.65E-7 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis