YBR090C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR090C / YBR090C

Click on Significant Values for Screen Details ID:SGTC_336|Compound:4111-0029|FD-Score:-3.52|P-value:4.82E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.09|P-value:3.09E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.65|P-value:2.92E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.70|P-value:2.26E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.23|P-value:1.75E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.88|P-value:7.73E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.47|P-value:6.17E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.73|P-value:1.96E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.02|P-value:4.37E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:2.96|P-value:5.58E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-2.95|P-value:5.46E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.78|P-value:1.43E-22 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.73|P-value:1.99E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.45|P-value:4.31E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.94|P-value:5.97E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.82|P-value:9.56E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.20|P-value:1.94E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.83|P-value:8.57E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.14|P-value:2.54E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.39|P-value:8.84E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.95|P-value:5.39E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.23|P-value:1.58E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-3.23|P-value:1.72E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.11|P-value:2.92E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.11|P-value:2.82E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.58|P-value:3.63E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.19|P-value:2.26E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.18|P-value:2.36E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.23|P-value:1.45E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.96|P-value:5.53E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.24|P-value:1.79E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.78|P-value:6.02E-8 ID:SGTC_2623|Compound:humulene|FD-Score:4.92|P-value:2.88E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.38|P-value:9.67E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.29|P-value:1.16E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.83|P-value:1.15E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.05|P-value:3.66E-4 ID:SGTC_3080|Compound:9117754|FD-Score:5.49|P-value:7.05E-10 ID:SGTC_3082|Compound:9117008|FD-Score:-3.43|P-value:7.28E-5 ID:SGTC_3085|Compound:9117376|FD-Score:-3.46|P-value:6.47E-5 ID:SGTC_3097|Compound:9117246|FD-Score:-3.05|P-value:3.60E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-2.91|P-value:6.30E-4 ID:SGTC_3251|Compound:9135047|FD-Score:2.86|P-value:8.07E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.87|P-value:7.42E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.94|P-value:6.50E-6 ID:SGTC_3313|Compound:9133968|FD-Score:4.02|P-value:4.68E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-4.33|P-value:8.19E-7 ID:SGTC_3329|Compound:9141233|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.96|P-value:5.79E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.52|P-value:4.82E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.09|P-value:3.09E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.65|P-value:2.92E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.70|P-value:2.26E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.23|P-value:1.75E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.88|P-value:7.73E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.47|P-value:6.17E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.73|P-value:1.96E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.02|P-value:4.37E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:2.96|P-value:5.58E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:-2.95|P-value:5.46E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.78|P-value:1.43E-22 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.73|P-value:1.99E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.45|P-value:4.31E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.94|P-value:5.97E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.82|P-value:9.56E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.20|P-value:1.94E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-2.83|P-value:8.57E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.14|P-value:2.54E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.39|P-value:8.84E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.95|P-value:5.39E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.23|P-value:1.58E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-3.23|P-value:1.72E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.11|P-value:2.92E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.11|P-value:2.82E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.58|P-value:3.63E-5 ID:SGTC_2511|Compound:berberine|FD-Score:3.19|P-value:2.26E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.18|P-value:2.36E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.23|P-value:1.45E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.96|P-value:5.53E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.24|P-value:1.79E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.78|P-value:6.02E-8 ID:SGTC_2623|Compound:humulene|FD-Score:4.92|P-value:2.88E-8 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.38|P-value:9.67E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.29|P-value:1.16E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:-3.83|P-value:1.15E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.05|P-value:3.66E-4 ID:SGTC_3080|Compound:9117754|FD-Score:5.49|P-value:7.05E-10 ID:SGTC_3082|Compound:9117008|FD-Score:-3.43|P-value:7.28E-5 ID:SGTC_3085|Compound:9117376|FD-Score:-3.46|P-value:6.47E-5 ID:SGTC_3097|Compound:9117246|FD-Score:-3.05|P-value:3.60E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-2.91|P-value:6.30E-4 ID:SGTC_3251|Compound:9135047|FD-Score:2.86|P-value:8.07E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-2.87|P-value:7.42E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.94|P-value:6.50E-6 ID:SGTC_3313|Compound:9133968|FD-Score:4.02|P-value:4.68E-6 ID:SGTC_3326|Compound:9140064|FD-Score:-4.33|P-value:8.19E-7 ID:SGTC_3329|Compound:9141233|FD-Score:-3.11|P-value:2.91E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.96|P-value:5.79E-6

Top fitness defect scores for YBR090C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3080 9117754 5.49 49.5 µM 7.05E-10 3 1.99E-8
2 SGTC_2623 humulene 4.92 100.0 µM 2.88E-8 9 4.27E-7
3 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.29 100.0 µM 1.16E-6 20 9.08E-6
4 SGTC_1996 st072960 4.23 66.8 µM 1.58E-6 11 1.17E-5
5 SGTC_3313 9133968 4.02 57.0 µM 4.68E-6 6 2.89E-5
6 SGTC_964 1287-0107 3.73 19.4 µM 1.96E-5 cell wall 52 9.46E-5
7 SGTC_1125 tnp00248 3.73 1.3 µM 1.99E-5 36 9.59E-5
8 SGTC_551 k048-0028 3.70 34.9 µM 2.26E-5 23 1.07E-4
9 SGTC_382 3229-0966 3.65 23.2 µM 2.92E-5 32 1.32E-4
10 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.38 100.0 µM 9.67E-5 59 3.57E-4
11 SGTC_2567 aureobasidin a 3.24 60.0 nM 1.79E-4 133 5.95E-4
12 SGTC_2511 berberine 3.19 10.5 µM 2.26E-4 60S ribosome export 47 7.22E-4
13 SGTC_2516 gossypol 3.18 71.5 µM 2.36E-4 46 7.49E-4
14 SGTC_1003 4049-0218 3.02 100.0 µM 4.37E-4 68 0.00125
15 SGTC_2564 betulinic acid 2.96 100.0 µM 5.53E-4 82 0.00152
16 SGTC_1058 3448-5425 2.96 97.3 µM 5.58E-4 69 0.00154
17 SGTC_1131 3454-3128 2.94 32.3 µM 5.97E-4 97 0.00163
18 SGTC_922 1866-0035 2.88 480.0 µM 7.73E-4 excess fatty acid 137 0.00201
19 SGTC_3251 9135047 2.86 49.5 µM 8.07E-4 60S ribosome export 31 0.00209
20 SGTC_1143 3454-2408 2.82 5.1 µM 9.56E-4 60S ribosome export 25 0.00241

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 1.77E-39 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.208 5.88E-34 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.197 1.25E-30 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.193 1.38E-29 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.192 3.04E-29 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.191 8.66E-29 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.190 1.44E-28 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.188 4.32E-28 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.187 1.18E-27 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.184 7.26E-27 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.178 2.42E-25 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.173 5.53E-24 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.168 1.36E-22 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.167 2.03E-22 YMR150C IMP1 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.166 5.21E-22 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3