YBR091C / TIM12

Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR091C / TIM12

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.94|P-value:5.88E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:6.99|P-value:4.18E-12 ID:SGTC_54|Compound:0159-0055|FD-Score:4.58|P-value:3.77E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:13.90|P-value:1.35E-42 ID:SGTC_61|Compound:0978-8327|FD-Score:4.89|P-value:8.76E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:3.83|P-value:8.99E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.53|P-value:2.79E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.80|P-value:1.01E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:17.10|P-value:4.78E-63 ID:SGTC_157|Compound:1348-1695|FD-Score:8.01|P-value:2.34E-15 ID:SGTC_168|Compound:3970-0862|FD-Score:3.47|P-value:3.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.79|P-value:1.43E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:5.09|P-value:3.22E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:8.03|P-value:1.99E-15 ID:SGTC_284|Compound:0988-0104|FD-Score:3.57|P-value:2.44E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:6.26|P-value:4.62E-10 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.25|P-value:7.51E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.88|P-value:7.54E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:8.87|P-value:2.01E-18 ID:SGTC_360|Compound:0957-0399|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.62|P-value:3.06E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:4.46|P-value:6.34E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.88|P-value:8.38E-12 ID:SGTC_514|Compound:4466-0038|FD-Score:4.79|P-value:1.44E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.26|P-value:7.09E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:8.55|P-value:3.15E-17 ID:SGTC_549|Compound:1661-1316|FD-Score:3.97|P-value:5.26E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.89|P-value:7.21E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.67|P-value:2.48E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:6.98|P-value:4.44E-12 ID:SGTC_610|Compound:4215-0184|FD-Score:4.19|P-value:2.07E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:6.03|P-value:1.91E-9 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.48|P-value:3.27E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.57|P-value:2.50E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.96|P-value:5.40E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:4.90|P-value:8.19E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:3.20|P-value:8.89E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:8.16|P-value:7.41E-16 ID:SGTC_839|Compound:0122-0028|FD-Score:5.12|P-value:2.77E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.71|P-value:1.40E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:6.68|P-value:3.23E-11 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.73|P-value:1.34E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:7.58|P-value:6.13E-14 ID:SGTC_883|Compound:0850-0245|FD-Score:4.39|P-value:8.90E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.36|P-value:5.05E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.19|P-value:1.04E-12 ID:SGTC_928|Compound:2764-0428|FD-Score:5.61|P-value:2.03E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:3.54|P-value:2.66E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:11.60|P-value:2.66E-30 ID:SGTC_1190|Compound:1486-1332|FD-Score:-4.13|P-value:2.69E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:5.00|P-value:5.18E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.36|P-value:5.11E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.04|P-value:4.19E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.67|P-value:1.67E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.99|P-value:7.19E-19 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.92|P-value:6.45E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.58|P-value:3.70E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.71|P-value:2.01E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.95|P-value:5.54E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.31|P-value:5.95E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.19|P-value:9.01E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.24|P-value:1.72E-5 ID:SGTC_1652|Compound:st011932|FD-Score:8.64|P-value:1.45E-17 ID:SGTC_1707|Compound:st032323|FD-Score:6.24|P-value:5.32E-10 ID:SGTC_1745|Compound:st081495|FD-Score:8.00|P-value:2.51E-15 ID:SGTC_1754|Compound:st042065|FD-Score:6.84|P-value:1.13E-11 ID:SGTC_1800|Compound:st050079|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.25|P-value:7.35E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-3.45|P-value:3.71E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.24|P-value:7.60E-4 ID:SGTC_1915|Compound:st067105|FD-Score:7.92|P-value:4.98E-15 ID:SGTC_1959|Compound:st077091|FD-Score:6.41|P-value:1.82E-10 ID:SGTC_2041|Compound:5107442|FD-Score:3.35|P-value:5.23E-4 ID:SGTC_2109|Compound:5483026|FD-Score:10.60|P-value:1.43E-25 ID:SGTC_2111|Compound:5486399|FD-Score:3.51|P-value:3.02E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.36|P-value:5.06E-4 ID:SGTC_2192|Compound:5915882|FD-Score:8.79|P-value:4.26E-18 ID:SGTC_2275|Compound:7947463|FD-Score:4.14|P-value:2.58E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.98|P-value:5.02E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-4.05|P-value:3.74E-5 ID:SGTC_2311|Compound:7694451|FD-Score:5.10|P-value:3.05E-7 ID:SGTC_2342|Compound:7990637|FD-Score:3.63|P-value:1.94E-4 ID:SGTC_2361|Compound:9034121|FD-Score:6.25|P-value:5.04E-10 ID:SGTC_2363|Compound:9053361|FD-Score:5.57|P-value:2.64E-8 ID:SGTC_2378|Compound:9074213|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.47|P-value:3.49E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.34|P-value:5.51E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.22|P-value:8.30E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.32|P-value:5.89E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.91|P-value:5.25E-15 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.26|P-value:1.52E-5 ID:SGTC_2800|Compound:7887935|FD-Score:5.06|P-value:3.66E-7 ID:SGTC_2912|Compound:7964298|FD-Score:11.60|P-value:2.86E-30 ID:SGTC_3347|Compound:9188721|FD-Score:7.39|P-value:2.56E-13 ID:SGTC_16|Compound:erodoxin|FD-Score:3.94|P-value:5.88E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:6.99|P-value:4.18E-12 ID:SGTC_54|Compound:0159-0055|FD-Score:4.58|P-value:3.77E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:13.90|P-value:1.35E-42 ID:SGTC_61|Compound:0978-8327|FD-Score:4.89|P-value:8.76E-7 ID:SGTC_62|Compound:0180-0423|FD-Score:3.83|P-value:8.99E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.53|P-value:2.79E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.80|P-value:1.01E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:17.10|P-value:4.78E-63 ID:SGTC_157|Compound:1348-1695|FD-Score:8.01|P-value:2.34E-15 ID:SGTC_168|Compound:3970-0862|FD-Score:3.47|P-value:3.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.79|P-value:1.43E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:5.09|P-value:3.22E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:8.03|P-value:1.99E-15 ID:SGTC_284|Compound:0988-0104|FD-Score:3.57|P-value:2.44E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:6.26|P-value:4.62E-10 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.25|P-value:7.51E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.88|P-value:7.54E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:8.87|P-value:2.01E-18 ID:SGTC_360|Compound:0957-0399|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.62|P-value:3.06E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:4.46|P-value:6.34E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.88|P-value:8.38E-12 ID:SGTC_514|Compound:4466-0038|FD-Score:4.79|P-value:1.44E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.26|P-value:7.09E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:8.55|P-value:3.15E-17 ID:SGTC_549|Compound:1661-1316|FD-Score:3.97|P-value:5.26E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.89|P-value:7.21E-5 ID:SGTC_584|Compound:0986-0246|FD-Score:4.67|P-value:2.48E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:6.98|P-value:4.44E-12 ID:SGTC_610|Compound:4215-0184|FD-Score:4.19|P-value:2.07E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:6.03|P-value:1.91E-9 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.48|P-value:3.27E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.57|P-value:2.50E-8 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.96|P-value:5.40E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:4.90|P-value:8.19E-7 ID:SGTC_825|Compound:1988-2224|FD-Score:3.20|P-value:8.89E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:8.16|P-value:7.41E-16 ID:SGTC_839|Compound:0122-0028|FD-Score:5.12|P-value:2.77E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.71|P-value:1.40E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:6.68|P-value:3.23E-11 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.73|P-value:1.34E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:7.58|P-value:6.13E-14 ID:SGTC_883|Compound:0850-0245|FD-Score:4.39|P-value:8.90E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.36|P-value:5.05E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.19|P-value:1.04E-12 ID:SGTC_928|Compound:2764-0428|FD-Score:5.61|P-value:2.03E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:3.54|P-value:2.66E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:11.60|P-value:2.66E-30 ID:SGTC_1190|Compound:1486-1332|FD-Score:-4.13|P-value:2.69E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:5.00|P-value:5.18E-7 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.36|P-value:5.11E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.04|P-value:4.19E-7 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.67|P-value:1.67E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.99|P-value:7.19E-19 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.92|P-value:6.45E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.58|P-value:3.70E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.71|P-value:2.01E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.95|P-value:5.54E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.31|P-value:5.95E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.19|P-value:9.01E-4 ID:SGTC_1651|Compound:st011928|FD-Score:4.24|P-value:1.72E-5 ID:SGTC_1652|Compound:st011932|FD-Score:8.64|P-value:1.45E-17 ID:SGTC_1707|Compound:st032323|FD-Score:6.24|P-value:5.32E-10 ID:SGTC_1745|Compound:st081495|FD-Score:8.00|P-value:2.51E-15 ID:SGTC_1754|Compound:st042065|FD-Score:6.84|P-value:1.13E-11 ID:SGTC_1800|Compound:st050079|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.25|P-value:7.35E-4 ID:SGTC_1833|Compound:st055984|FD-Score:-3.45|P-value:3.71E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.24|P-value:7.60E-4 ID:SGTC_1915|Compound:st067105|FD-Score:7.92|P-value:4.98E-15 ID:SGTC_1959|Compound:st077091|FD-Score:6.41|P-value:1.82E-10 ID:SGTC_2041|Compound:5107442|FD-Score:3.35|P-value:5.23E-4 ID:SGTC_2109|Compound:5483026|FD-Score:10.60|P-value:1.43E-25 ID:SGTC_2111|Compound:5486399|FD-Score:3.51|P-value:3.02E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.36|P-value:5.06E-4 ID:SGTC_2192|Compound:5915882|FD-Score:8.79|P-value:4.26E-18 ID:SGTC_2275|Compound:7947463|FD-Score:4.14|P-value:2.58E-5 ID:SGTC_2277|Compound:7947813|FD-Score:3.98|P-value:5.02E-5 ID:SGTC_2286|Compound:7945697|FD-Score:-4.05|P-value:3.74E-5 ID:SGTC_2311|Compound:7694451|FD-Score:5.10|P-value:3.05E-7 ID:SGTC_2342|Compound:7990637|FD-Score:3.63|P-value:1.94E-4 ID:SGTC_2361|Compound:9034121|FD-Score:6.25|P-value:5.04E-10 ID:SGTC_2363|Compound:9053361|FD-Score:5.57|P-value:2.64E-8 ID:SGTC_2378|Compound:9074213|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.47|P-value:3.49E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.34|P-value:5.51E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.22|P-value:8.30E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.44|P-value:3.86E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.32|P-value:5.89E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.91|P-value:5.25E-15 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.26|P-value:1.52E-5 ID:SGTC_2800|Compound:7887935|FD-Score:5.06|P-value:3.66E-7 ID:SGTC_2912|Compound:7964298|FD-Score:11.60|P-value:2.86E-30 ID:SGTC_3347|Compound:9188721|FD-Score:7.39|P-value:2.56E-13

Top fitness defect scores for YBR091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_138 0850-0259 17.10 40.9 µM 4.78E-63 cell wall 3 7.86E-66 1.97
2 SGTC_58 0957-0393 13.90 9.0 µM 1.35E-42 cell wall 2 1.90E-44 0.65
3 SGTC_1133 3473-0247 11.60 50.0 µM 2.66E-30 RSC complex & mRNA processing 4 1.35E-31 0.91
4 SGTC_2912 7964298 11.60 10.9 µM 2.86E-30 cell wall 10 1.45E-31 0.67
5 SGTC_2109 5483026 10.60 200.0 µM 1.43E-25 RSC complex & mRNA processing 6 1.19E-26 0.27
6 SGTC_1374 2889-5571 8.99 141.0 µM 7.19E-19 RSC complex & mRNA processing 14 1.20E-19 0.06
7 SGTC_354 2783-3500 8.87 4.9 µM 2.01E-18 cell wall 5 3.50E-19 1.33
8 SGTC_2192 5915882 8.79 198.5 µM 4.26E-18 RNA processing & uracil transport 3 7.69E-19 0.16
9 SGTC_1652 st011932 8.64 78.0 µM 1.45E-17 RSC complex & mRNA processing 14 2.76E-18 0.26
10 SGTC_525 k781-2675 8.55 26.7 µM 3.15E-17 redox potentiating 6 6.22E-18 0.51
11 SGTC_829 1635-0120 8.16 117.0 µM 7.41E-16 DNA damage response 13 1.69E-16 0.11
12 SGTC_268 camptothecin 8.03 39.6 µM 1.99E-15 DNA damage response 12 4.75E-16 0.58
13 SGTC_157 1348-1695 8.01 65.8 µM 2.34E-15 iron homeostasis 13 5.61E-16 0.04
14 SGTC_1745 st081495 8.00 74.0 µM 2.51E-15 RNA processing & uracil transport 9 6.04E-16 0.44
15 SGTC_1915 st067105 7.92 30.6 µM 4.98E-15 RNA pol III & RNase P/MRP 11 1.24E-15 0.16
16 SGTC_2679 rapamycin 7.91 1.0 nM 5.25E-15 17 1.31E-15 0.03
17 SGTC_871 0574-0004 7.58 149.0 µM 6.13E-14 12 1.70E-14 1.22
18 SGTC_3347 9188721 7.39 44.7 µM 2.56E-13 6 7.60E-14 1.27
19 SGTC_916 4466-0038 7.19 42.0 nM 1.04E-12 cell wall 10 3.27E-13 0.39
20 SGTC_22 0964-0034 6.99 14.5 µM 4.18E-12 unfolded protein response 9 1.40E-12 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.649 0 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.594 2.59E-319 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.552 4.83E-267 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.512 6.61E-223 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.479 1.93E-192 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.435 7.67E-155 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.429 2.04E-150 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.392 8.04E-124 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.388 4.71E-121 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.369 4.25E-109 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.364 1.57E-105 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.360 2.52E-103 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.347 1.13E-95 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.343 3.02E-93 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.335 5.17E-89 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2