HIPHOP chemogenomics database

YBR094W / PBY1

Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR094W / PBY1

Click on Significant Values for Screen Details

Top fitness defect scores for YBR094W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2752	diclazuril	5.31	33.1 µM	3.05E-9		69	5.33E-8
2	SGTC_2102	5377816	5.15	72.8 µM	8.86E-9		5	1.30E-7
3	SGTC_2086	5274770	5.09	176.6 µM	1.27E-8		8	1.77E-7
4	SGTC_213	1246-0773	4.88	967.0 nM	4.83E-8		7	5.42E-7
5	SGTC_2022	5136654	4.61	200.0 µM	2.26E-7		11	1.98E-6
6	SGTC_2533	agelasine	4.46	13.7 µM	5.34E-7	ERG2	38	4.08E-6
7	SGTC_151	3013-0144	4.21	2.3 µM	2.05E-6	iron homeostasis	23	1.27E-5
8	SGTC_2513	baicalein	4.14	25.6 µM	2.92E-6	calcium & mitochondrial duress	23	1.70E-5
9	SGTC_1453	4237-0541	3.94	195.0 µM	8.33E-6	heme biosynthesis & mitochondrial translocase	26	4.12E-5
10	SGTC_1348	1493-0373	3.80	93.8 µM	1.61E-5		17	7.18E-5
11	SGTC_1198	1612-1005	3.77	86.7 µM	1.90E-5		17	8.24E-5
12	SGTC_2858	9025781	3.72	9.0 µM	2.37E-5	sphingolipid biosynthesis & PDR1	109	9.94E-5
13	SGTC_2598	perillyl alcohol	3.57	100.0 µM	4.80E-5		48	1.80E-4
14	SGTC_498	2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)	3.57	150.0 µM	4.82E-5	Golgi	53	1.81E-4
15	SGTC_1590	st077108	3.52	57.8 µM	5.84E-5		10	2.12E-4
16	SGTC_928	2764-0428	3.27	58.7 µM	1.75E-4	cell wall	92	5.36E-4
17	SGTC_501	nsc-95397	3.23	161.0 µM	2.08E-4		31	6.22E-4
18	SGTC_922	1866-0035	3.20	480.0 µM	2.35E-4	excess fatty acid	108	6.89E-4
19	SGTC_306	1672-3436	3.18	11.6 µM	2.51E-4	Golgi	37	7.27E-4
20	SGTC_1181	1222-0449	3.14	220.0 µM	2.95E-4		53	8.34E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.123	8.46E-13	YPL265W	DIP5	hom	Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.116	1.45E-11	YIL170W	HXT12	hom	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.115	1.97E-11	YPR159C-A_p	YPR159C-A_p	hom	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.112	6.73E-11	YLR247C	IRC20	hom	Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.102	3.73E-9	YGL035C	MIG1	hom	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.099	8.02E-9	YLR019W	PSR2	hom	Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.099	8.22E-9	YKL063C_p	YKL063C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.098	1.22E-8	YNR001C	CIT1	hom	Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.094	5.64E-8	YGR028W	MSP1	hom	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
0.091	1.16E-7	YEL060C	PRB1	hom	Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.090	1.61E-7	YDR120C	TRM1	hom	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.089	2.13E-7	YLR055C	SPT8	hom	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.089	2.20E-7	YBR101C	FES1	hom	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.089	2.46E-7	YGL066W	SGF73	hom	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.088	3.55E-7	YOL154W	ZPS1	hom	Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH