YBR094W / PBY1

Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR094W / PBY1

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:-4.38|P-value:7.63E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.74|P-value:2.00E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.95|P-value:7.50E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:2.97|P-value:5.82E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.21|P-value:2.05E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.19|P-value:2.34E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.88|P-value:4.83E-8 ID:SGTC_306|Compound:1672-3436|FD-Score:3.18|P-value:2.51E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-2.82|P-value:9.95E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.97|P-value:5.55E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.05|P-value:4.02E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.95|P-value:6.04E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.57|P-value:4.82E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.23|P-value:2.08E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.05|P-value:4.21E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.13|P-value:3.18E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.20|P-value:2.35E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.27|P-value:1.75E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.14|P-value:2.95E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.77|P-value:1.90E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:-2.84|P-value:9.22E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.80|P-value:1.61E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.44|P-value:8.14E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:-5.39|P-value:1.76E-9 ID:SGTC_1402|Compound:3909-7673|FD-Score:-4.18|P-value:2.25E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.94|P-value:8.33E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.68|P-value:2.65E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.52|P-value:5.84E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.08|P-value:3.83E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.61|P-value:2.26E-7 ID:SGTC_2024|Compound:5144227|FD-Score:2.84|P-value:9.64E-4 ID:SGTC_2086|Compound:5274770|FD-Score:5.09|P-value:1.27E-8 ID:SGTC_2094|Compound:5332512|FD-Score:-3.51|P-value:5.82E-5 ID:SGTC_2102|Compound:5377816|FD-Score:5.15|P-value:8.86E-9 ID:SGTC_2513|Compound:baicalein|FD-Score:4.14|P-value:2.92E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:4.46|P-value:5.34E-7 ID:SGTC_2537|Compound:larixol|FD-Score:2.85|P-value:9.17E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.57|P-value:4.80E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-5.33|P-value:2.49E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.31|P-value:3.05E-9 ID:SGTC_2858|Compound:9025781|FD-Score:3.72|P-value:2.37E-5 ID:SGTC_2928|Compound:9011484|FD-Score:2.91|P-value:7.33E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.88|P-value:8.35E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.05|P-value:4.35E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.33|P-value:1.27E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.38|P-value:7.63E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.74|P-value:2.00E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.95|P-value:7.50E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:2.97|P-value:5.82E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.21|P-value:2.05E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.19|P-value:2.34E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.88|P-value:4.83E-8 ID:SGTC_306|Compound:1672-3436|FD-Score:3.18|P-value:2.51E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-2.82|P-value:9.95E-4 ID:SGTC_456|Compound:gingerol|FD-Score:-2.97|P-value:5.55E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.05|P-value:4.02E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.95|P-value:6.04E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.57|P-value:4.82E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.23|P-value:2.08E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.05|P-value:4.21E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.13|P-value:3.18E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.20|P-value:2.35E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.27|P-value:1.75E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.14|P-value:2.95E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.77|P-value:1.90E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:-2.84|P-value:9.22E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.80|P-value:1.61E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.44|P-value:8.14E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:-5.39|P-value:1.76E-9 ID:SGTC_1402|Compound:3909-7673|FD-Score:-4.18|P-value:2.25E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.94|P-value:8.33E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.68|P-value:2.65E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.52|P-value:5.84E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.08|P-value:3.83E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.61|P-value:2.26E-7 ID:SGTC_2024|Compound:5144227|FD-Score:2.84|P-value:9.64E-4 ID:SGTC_2086|Compound:5274770|FD-Score:5.09|P-value:1.27E-8 ID:SGTC_2094|Compound:5332512|FD-Score:-3.51|P-value:5.82E-5 ID:SGTC_2102|Compound:5377816|FD-Score:5.15|P-value:8.86E-9 ID:SGTC_2513|Compound:baicalein|FD-Score:4.14|P-value:2.92E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:4.46|P-value:5.34E-7 ID:SGTC_2537|Compound:larixol|FD-Score:2.85|P-value:9.17E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.57|P-value:4.80E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-5.33|P-value:2.49E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.31|P-value:3.05E-9 ID:SGTC_2858|Compound:9025781|FD-Score:3.72|P-value:2.37E-5 ID:SGTC_2928|Compound:9011484|FD-Score:2.91|P-value:7.33E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.88|P-value:8.35E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.05|P-value:4.35E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.33|P-value:1.27E-4

Top fitness defect scores for YBR094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2752 diclazuril 5.31 33.1 µM 3.05E-9 69 5.33E-8
2 SGTC_2102 5377816 5.15 72.8 µM 8.86E-9 5 1.30E-7
3 SGTC_2086 5274770 5.09 176.6 µM 1.27E-8 8 1.77E-7
4 SGTC_213 1246-0773 4.88 967.0 nM 4.83E-8 7 5.42E-7
5 SGTC_2022 5136654 4.61 200.0 µM 2.26E-7 11 1.98E-6
6 SGTC_2533 agelasine 4.46 13.7 µM 5.34E-7 ERG2 38 4.08E-6
7 SGTC_151 3013-0144 4.21 2.3 µM 2.05E-6 iron homeostasis 23 1.27E-5
8 SGTC_2513 baicalein 4.14 25.6 µM 2.92E-6 calcium & mitochondrial duress 23 1.70E-5
9 SGTC_1453 4237-0541 3.94 195.0 µM 8.33E-6 heme biosynthesis & mitochondrial translocase 26 4.12E-5
10 SGTC_1348 1493-0373 3.80 93.8 µM 1.61E-5 17 7.18E-5
11 SGTC_1198 1612-1005 3.77 86.7 µM 1.90E-5 17 8.24E-5
12 SGTC_2858 9025781 3.72 9.0 µM 2.37E-5 sphingolipid biosynthesis & PDR1 109 9.94E-5
13 SGTC_2598 perillyl alcohol 3.57 100.0 µM 4.80E-5 48 1.80E-4
14 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.57 150.0 µM 4.82E-5 Golgi 53 1.81E-4
15 SGTC_1590 st077108 3.52 57.8 µM 5.84E-5 10 2.12E-4
16 SGTC_928 2764-0428 3.27 58.7 µM 1.75E-4 cell wall 92 5.36E-4
17 SGTC_501 nsc-95397 3.23 161.0 µM 2.08E-4 31 6.22E-4
18 SGTC_922 1866-0035 3.20 480.0 µM 2.35E-4 excess fatty acid 108 6.89E-4
19 SGTC_306 1672-3436 3.18 11.6 µM 2.51E-4 Golgi 37 7.27E-4
20 SGTC_1181 1222-0449 3.14 220.0 µM 2.95E-4 53 8.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.46E-13 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.116 1.45E-11 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.115 1.97E-11 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.112 6.73E-11 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.102 3.73E-9 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.099 8.02E-9 YLR019W PSR2 hom Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.099 8.22E-9 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.098 1.22E-8 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.094 5.64E-8 YGR028W MSP1 hom Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
0.091 1.16E-7 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.090 1.61E-7 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.089 2.13E-7 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.089 2.20E-7 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.089 2.46E-7 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.088 3.55E-7 YOL154W ZPS1 hom Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH