YBR097W / VPS15

Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR097W / VPS15

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.50|P-value:1.32E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.17|P-value:4.19E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.56|P-value:1.02E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.30|P-value:1.25E-8 ID:SGTC_72|Compound:0744-0168|FD-Score:4.88|P-value:1.74E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:-4.32|P-value:2.69E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.56|P-value:9.05E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.15|P-value:6.28E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.58|P-value:9.41E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.20|P-value:3.78E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.35|P-value:2.39E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.12|P-value:7.33E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-5.13|P-value:3.49E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.10|P-value:6.08E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.20|P-value:4.31E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.05|P-value:7.25E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.35|P-value:2.11E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.24|P-value:3.28E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.10|P-value:5.47E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.78|P-value:3.41E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-4.98|P-value:8.10E-8 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.19|P-value:3.95E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.01|P-value:8.41E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.13|P-value:4.83E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.15|P-value:4.55E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.11|P-value:5.91E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.85|P-value:2.89E-5 ID:SGTC_1920|Compound:st075728|FD-Score:-3.04|P-value:6.84E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.61|P-value:7.19E-5 ID:SGTC_1931|Compound:st074438|FD-Score:4.27|P-value:4.08E-6 ID:SGTC_1932|Compound:st074806|FD-Score:4.77|P-value:3.21E-7 ID:SGTC_1935|Compound:st074532|FD-Score:3.84|P-value:3.10E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-4.34|P-value:2.47E-6 ID:SGTC_2069|Compound:5228469|FD-Score:-3.62|P-value:6.94E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-2.96|P-value:9.23E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.23|P-value:2.35E-8 ID:SGTC_2484|Compound:5809818|FD-Score:-4.57|P-value:7.83E-7 ID:SGTC_2585|Compound:alliin|FD-Score:-2.95|P-value:9.24E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.40|P-value:1.74E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.16|P-value:5.01E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.98|P-value:9.63E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-4.12|P-value:7.19E-6 ID:SGTC_2784|Compound:7567673|FD-Score:4.39|P-value:2.25E-6 ID:SGTC_2787|Compound:5284540|FD-Score:-4.14|P-value:6.71E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.09|P-value:9.79E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.11|P-value:5.22E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.13|P-value:5.58E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.50|P-value:1.32E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.17|P-value:4.19E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.56|P-value:1.02E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.30|P-value:1.25E-8 ID:SGTC_72|Compound:0744-0168|FD-Score:4.88|P-value:1.74E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:-4.32|P-value:2.69E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.56|P-value:9.05E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.15|P-value:6.28E-6 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.58|P-value:9.41E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.20|P-value:3.78E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.35|P-value:2.39E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.12|P-value:7.33E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-5.13|P-value:3.49E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.10|P-value:6.08E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.20|P-value:4.31E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.05|P-value:7.25E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.35|P-value:2.11E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:-3.24|P-value:3.28E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.10|P-value:5.47E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-3.78|P-value:3.41E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-4.98|P-value:8.10E-8 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.19|P-value:3.95E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.01|P-value:8.41E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.13|P-value:4.83E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:-3.15|P-value:4.55E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.11|P-value:5.91E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.85|P-value:2.89E-5 ID:SGTC_1920|Compound:st075728|FD-Score:-3.04|P-value:6.84E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-3.61|P-value:7.19E-5 ID:SGTC_1931|Compound:st074438|FD-Score:4.27|P-value:4.08E-6 ID:SGTC_1932|Compound:st074806|FD-Score:4.77|P-value:3.21E-7 ID:SGTC_1935|Compound:st074532|FD-Score:3.84|P-value:3.10E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-4.34|P-value:2.47E-6 ID:SGTC_2069|Compound:5228469|FD-Score:-3.62|P-value:6.94E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-2.96|P-value:9.23E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.23|P-value:2.35E-8 ID:SGTC_2484|Compound:5809818|FD-Score:-4.57|P-value:7.83E-7 ID:SGTC_2585|Compound:alliin|FD-Score:-2.95|P-value:9.24E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.40|P-value:1.74E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.16|P-value:5.01E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.98|P-value:9.63E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-4.12|P-value:7.19E-6 ID:SGTC_2784|Compound:7567673|FD-Score:4.39|P-value:2.25E-6 ID:SGTC_2787|Compound:5284540|FD-Score:-4.14|P-value:6.71E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.09|P-value:9.79E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.11|P-value:5.22E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.13|P-value:5.58E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.38|P-value:2.15E-4

Top fitness defect scores for YBR097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2476 5806916 5.23 10.5 µM 2.35E-8 3 8.58E-8
2 SGTC_72 0744-0168 4.88 198.4 µM 1.74E-7 RPP1 & pyrimidine depletion 17 5.36E-7
3 SGTC_1932 st074806 4.77 40.9 µM 3.21E-7 6 9.38E-7
4 SGTC_2784 7567673 4.39 72.7 µM 2.25E-6 iron homeostasis 22 5.60E-6
5 SGTC_1931 st074438 4.27 57.1 µM 4.08E-6 11 9.66E-6
6 SGTC_2791 5663188 4.09 71.4 µM 9.79E-6 RPP1 & pyrimidine depletion 18 2.16E-5
7 SGTC_1676 st018489 3.85 23.4 µM 2.89E-5 60S ribosome export 40 5.83E-5
8 SGTC_1935 st074532 3.84 41.6 µM 3.10E-5 35 6.22E-5
9 SGTC_234 nsc-17383 3.58 10.7 µM 9.41E-5 ERG2 31 1.72E-4
10 SGTC_66 0109-0187 3.56 42.4 µM 1.02E-4 51 1.86E-4
11 SGTC_11 0438-0307 3.50 1.3 µM 1.32E-4 15 2.35E-4
12 SGTC_3343 9148379 3.38 19.0 µM 2.15E-4 14 3.69E-4
13 SGTC_542 3381-0244 3.20 89.3 µM 4.31E-4 74 6.98E-4
14 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.16 100.0 µM 5.01E-4 54 8.02E-4
15 SGTC_3093 9117344 3.13 49.5 µM 5.58E-4 60S ribosome export 54 8.86E-4
16 SGTC_1475 4092-1048 3.11 11.7 µM 5.91E-4 plasma membrane duress 83 9.33E-4
17 SGTC_391 gliotoxin 3.10 8.3 µM 6.08E-4 94 9.58E-4
18 SGTC_694 1315-0438 3.05 43.2 µM 7.25E-4 42 0.00113
19 SGTC_1246 0422-0085 3.01 105.0 µM 8.41E-4 80 0.00129
20 SGTC_2724 maprotiline 2.98 69.6 µM 9.63E-4 ERG2 53 0.00146

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 2.03E-17 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.107 5.05E-10 YJL117W PHO86 hom Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress
0.096 2.22E-8 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.093 6.78E-8 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.092 9.81E-8 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.091 1.15E-7 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.091 1.25E-7 YDR015C_d YDR015C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A
0.088 3.06E-7 YER079W_p YER079W_p hom Putative protein of unknown function
0.087 3.93E-7 YER105C NUP157 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
0.087 4.75E-7 YKR105C_p VBA5_p hom Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p
0.083 1.37E-6 YOL110W SHR5 hom Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization
0.081 2.49E-6 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.081 2.67E-6 YIL103W DPH1 hom Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
0.080 3.05E-6 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.080 3.77E-6 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs