YBR118W / TEF2

Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR118W / TEF2

Click on Significant Values for Screen Details ID:SGTC_374|Compound:0880-0231|FD-Score:2.97|P-value:7.53E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.03|P-value:9.13E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.97|P-value:9.30E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.92|P-value:1.47E-13 ID:SGTC_798|Compound:1287-0182|FD-Score:3.37|P-value:1.63E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.37|P-value:1.66E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.45|P-value:1.19E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.18|P-value:2.48E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.61|P-value:7.60E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:-2.99|P-value:8.59E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.58|P-value:7.04E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.34|P-value:2.22E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.90|P-value:9.93E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.91|P-value:1.58E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.06|P-value:6.56E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.17|P-value:3.60E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.59|P-value:6.79E-7 ID:SGTC_2018|Compound:5133068|FD-Score:-3.14|P-value:4.99E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.05|P-value:5.73E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.35|P-value:2.17E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-5.71|P-value:9.22E-10 ID:SGTC_2369|Compound:9071472|FD-Score:-3.20|P-value:3.90E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.08|P-value:5.02E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-5.32|P-value:1.06E-8 ID:SGTC_2401|Compound:5128683|FD-Score:-4.14|P-value:6.59E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-3.12|P-value:5.38E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.56|P-value:7.47E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.72|P-value:4.66E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.12|P-value:5.30E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.10|P-value:4.82E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.95|P-value:9.97E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.04|P-value:5.94E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.97|P-value:7.53E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.03|P-value:9.13E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.97|P-value:9.30E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.92|P-value:1.47E-13 ID:SGTC_798|Compound:1287-0182|FD-Score:3.37|P-value:1.63E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.37|P-value:1.66E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.45|P-value:1.19E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.18|P-value:2.48E-8 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.61|P-value:7.60E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:-2.99|P-value:8.59E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.58|P-value:7.04E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.34|P-value:2.22E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.90|P-value:9.93E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.91|P-value:1.58E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.06|P-value:6.56E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.17|P-value:3.60E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.59|P-value:6.79E-7 ID:SGTC_2018|Compound:5133068|FD-Score:-3.14|P-value:4.99E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.41|P-value:1.42E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.05|P-value:5.73E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.35|P-value:2.17E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-5.71|P-value:9.22E-10 ID:SGTC_2369|Compound:9071472|FD-Score:-3.20|P-value:3.90E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.08|P-value:5.02E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-5.32|P-value:1.06E-8 ID:SGTC_2401|Compound:5128683|FD-Score:-4.14|P-value:6.59E-6 ID:SGTC_2445|Compound:5742597|FD-Score:-3.12|P-value:5.38E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.56|P-value:7.47E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.72|P-value:4.66E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.12|P-value:5.30E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.10|P-value:4.82E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.95|P-value:9.97E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.04|P-value:5.94E-4

Top fitness defect scores for YBR118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_410 α-linolenic acid 4.03 100.0 µM 9.13E-6 excess fatty acid 36 2.84E-5
2 SGTC_1525 8-methoxypsoralen 3.91 92.5 µM 1.58E-5 DNA damage response 33 4.63E-5
3 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.56 63.6 µM 7.47E-5 58 1.86E-4
4 SGTC_933 2914-0560 3.45 114.0 µM 1.19E-4 44 2.82E-4
5 SGTC_2316 5844804 3.41 197.4 µM 1.42E-4 61 3.29E-4
6 SGTC_798 1287-0182 3.37 476.0 µM 1.63E-4 46 3.74E-4
7 SGTC_810 3825-7150 3.37 143.0 µM 1.66E-4 60S ribosome export 20 3.80E-4
8 SGTC_2347 9049783 3.18 174.8 µM 3.47E-4 61 7.34E-4
9 SGTC_1306 1185-0270 3.18 9.0 µM 3.49E-4 Golgi 75 7.36E-4
10 SGTC_1907 st060210 3.17 83.7 µM 3.60E-4 54 7.57E-4
11 SGTC_2750 bromebric acid 3.10 70.2 µM 4.82E-4 81 9.83E-4
12 SGTC_2371 9071574 3.08 200.0 µM 5.02E-4 38 0.00102
13 SGTC_2322 7413319 3.05 38.2 µM 5.73E-4 ERAD & cell cycle 229 0.00115
14 SGTC_3018 9082602 3.04 49.5 µM 5.94E-4 72 0.00119
15 SGTC_374 0880-0231 2.97 82.3 µM 7.53E-4 iron homeostasis 63 0.00147
16 SGTC_1524 corynanthine 2.90 62.1 µM 9.93E-4 77 0.00188
17 SGTC_2566 crystal violet carbinol 2.87 226.0 nM 0.00110 97 0.00206
18 SGTC_2794 7785382 2.85 27.3 µM 0.00116 106 0.00216
19 SGTC_3014 9081533 2.82 49.5 µM 0.00131 48 0.00241
20 SGTC_145 3737-0113 2.78 38.4 µM 0.00151 DNA intercalators 165 0.00274

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 8.06E-78 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.304 6.85E-73 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.272 5.98E-58 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.270 5.95E-57 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.239 6.28E-45 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.239 8.80E-45 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.226 6.15E-40 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.220 6.92E-38 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.215 1.84E-36 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.210 7.92E-35 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.209 1.74E-34 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.208 3.77E-34 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.206 1.81E-33 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.205 2.48E-33 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.204 5.31E-33 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress