YBR120C / CBP6

Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR120C / CBP6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:16.70|P-value:9.18E-67 ID:SGTC_151|Compound:3013-0144|FD-Score:3.50|P-value:1.57E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.20|P-value:4.91E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.24|P-value:4.16E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.94|P-value:2.42E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.71|P-value:6.68E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.73|P-value:5.98E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.88|P-value:3.16E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:3.09|P-value:7.17E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.86|P-value:3.47E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.64|P-value:8.95E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.22|P-value:6.83E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:3.19|P-value:5.02E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.24|P-value:4.16E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.54|P-value:1.30E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.38|P-value:3.23E-6 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.13|P-value:1.05E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.26|P-value:3.81E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.44|P-value:1.99E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.32|P-value:3.08E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.13|P-value:6.19E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.70|P-value:6.85E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.13|P-value:1.04E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.29|P-value:3.55E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.42|P-value:2.13E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.46|P-value:1.84E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.39|P-value:2.35E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-6.91|P-value:5.34E-13 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.12|P-value:6.54E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.06|P-value:8.03E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.44|P-value:2.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.91|P-value:2.07E-7 ID:SGTC_2824|Compound:7998404|FD-Score:5.11|P-value:7.18E-8 ID:SGTC_2846|Compound:9008642|FD-Score:3.04|P-value:8.67E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.41|P-value:2.70E-6 ID:SGTC_3007|Compound:9078383|FD-Score:6.39|P-value:2.33E-11 ID:SGTC_3032|Compound:9089427|FD-Score:3.04|P-value:8.80E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.27|P-value:3.78E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:16.70|P-value:9.18E-67 ID:SGTC_151|Compound:3013-0144|FD-Score:3.50|P-value:1.57E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.20|P-value:4.91E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.24|P-value:4.16E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.94|P-value:2.42E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.71|P-value:6.68E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:3.73|P-value:5.98E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.88|P-value:3.16E-5 ID:SGTC_624|Compound:k048-0052|FD-Score:3.09|P-value:7.17E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.86|P-value:3.47E-5 ID:SGTC_917|Compound:harmaline|FD-Score:3.64|P-value:8.95E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.22|P-value:6.83E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:3.19|P-value:5.02E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-3.24|P-value:4.16E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.54|P-value:1.30E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.38|P-value:3.23E-6 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.13|P-value:1.05E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.16|P-value:5.68E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.26|P-value:3.81E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.95|P-value:2.38E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.44|P-value:1.99E-4 ID:SGTC_1768|Compound:st044301|FD-Score:-3.32|P-value:3.08E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.13|P-value:6.19E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.70|P-value:6.85E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.13|P-value:1.04E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.29|P-value:3.55E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.42|P-value:2.13E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.46|P-value:1.84E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.39|P-value:2.35E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-6.91|P-value:5.34E-13 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.12|P-value:6.54E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.45|P-value:1.89E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.06|P-value:8.03E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.44|P-value:2.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.91|P-value:2.07E-7 ID:SGTC_2824|Compound:7998404|FD-Score:5.11|P-value:7.18E-8 ID:SGTC_2846|Compound:9008642|FD-Score:3.04|P-value:8.67E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.41|P-value:2.70E-6 ID:SGTC_3007|Compound:9078383|FD-Score:6.39|P-value:2.33E-11 ID:SGTC_3032|Compound:9089427|FD-Score:3.04|P-value:8.80E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-3.27|P-value:3.78E-4

Top fitness defect scores for YBR120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 16.70 9.0 µM 9.18E-67 cell wall 23 5.43E-63
2 SGTC_3007 9078383 6.39 71.4 µM 2.33E-11 2 8.46E-11
3 SGTC_2824 7998404 5.11 52.0 µM 7.18E-8 13 1.65E-7
4 SGTC_2816 7982706 4.91 58.4 µM 2.07E-7 azole & statin 31 4.47E-7
5 SGTC_3006 9075424 4.41 71.4 µM 2.70E-6 7 5.06E-6
6 SGTC_1203 3992-3522 4.38 103.0 µM 3.23E-6 18 5.99E-6
7 SGTC_2415 st077333 4.13 57.7 µM 1.04E-5 38 1.80E-5
8 SGTC_1421 4029-0249 4.13 71.4 µM 1.05E-5 14 1.83E-5
9 SGTC_1587 estradiol valerate 3.95 56.1 µM 2.38E-5 11 3.94E-5
10 SGTC_536 3852-0578 3.94 10.6 µM 2.42E-5 23 4.01E-5
11 SGTC_610 4215-0184 3.88 155.0 µM 3.16E-5 exosome 15 5.16E-5
12 SGTC_605 1315-0399 3.73 119.0 µM 5.98E-5 Golgi 32 9.43E-5
13 SGTC_574 1315-0397 3.71 40.0 µM 6.68E-5 45 1.05E-4
14 SGTC_2110 5483698 3.70 200.0 µM 6.85E-5 TSC3-RPN4 28 1.07E-4
15 SGTC_917 harmaline 3.64 728.1 nM 8.95E-5 ergosterol biosynthesis 37 1.38E-4
16 SGTC_805 3852-0218 3.55 479.0 µM 1.30E-4 ERAD & cell cycle 87 1.96E-4
17 SGTC_1184 1269-1718 3.54 139.0 µM 1.30E-4 44 1.97E-4
18 SGTC_151 3013-0144 3.50 2.3 µM 1.57E-4 iron homeostasis 45 2.34E-4
19 SGTC_2022 5136654 3.50 200.0 µM 1.58E-4 32 2.36E-4
20 SGTC_1718 roemerine 3.44 11.9 µM 1.99E-4 redox potentiating 84 2.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.389 7.86E-122 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.363 2.44E-105 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.334 1.77E-88 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.328 3.47E-85 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.322 1.19E-81 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.302 6.70E-72 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.295 3.27E-68 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.295 3.70E-68 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.284 3.70E-63 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.272 3.42E-58 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.269 8.55E-57 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.268 2.17E-56 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.268 4.36E-56 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.263 4.11E-54 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.261 1.92E-53 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated