YBR138C_p

Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR138C / YBR138C

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:4.50|P-value:3.63E-7 ID:SGTC_56|Compound:0957-0365|FD-Score:3.81|P-value:1.30E-5 ID:SGTC_57|Compound:miconazole|FD-Score:5.71|P-value:1.99E-10 ID:SGTC_65|Compound:0798-0905|FD-Score:4.76|P-value:8.20E-8 ID:SGTC_199|Compound:4063-0024|FD-Score:2.96|P-value:5.06E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.19|P-value:1.89E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:3.21|P-value:1.86E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.82|P-value:8.29E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.58|P-value:3.68E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:4.13|P-value:2.63E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.00|P-value:4.95E-6 ID:SGTC_560|Compound:2332-1943|FD-Score:-4.31|P-value:2.61E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.16|P-value:2.21E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.57|P-value:5.07E-10 ID:SGTC_621|Compound:3584-0052|FD-Score:3.14|P-value:2.40E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:2.91|P-value:5.94E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.88|P-value:2.19E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.55|P-value:7.62E-7 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.60|P-value:5.77E-7 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.97|P-value:1.42E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.95|P-value:6.45E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:3.07|P-value:3.26E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.27|P-value:1.43E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.18|P-value:4.37E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.26|P-value:3.16E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.93|P-value:5.53E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.69|P-value:2.30E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:5.31|P-value:2.86E-9 ID:SGTC_889|Compound:0919-1524|FD-Score:3.06|P-value:3.33E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.07|P-value:3.21E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.57|P-value:8.59E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.46|P-value:6.22E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.75|P-value:1.73E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.01|P-value:4.14E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:2.95|P-value:5.24E-4 ID:SGTC_1653|Compound:st012112|FD-Score:4.00|P-value:5.07E-6 ID:SGTC_1761|Compound:st044296|FD-Score:2.94|P-value:5.40E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.03|P-value:3.77E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.01|P-value:4.05E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.66|P-value:2.60E-5 ID:SGTC_2421|Compound:5690543|FD-Score:2.99|P-value:4.45E-4 ID:SGTC_2439|Compound:5492030|FD-Score:7.10|P-value:4.26E-15 ID:SGTC_2441|Compound:5730946|FD-Score:5.05|P-value:1.49E-8 ID:SGTC_2451|Compound:5856223|FD-Score:5.20|P-value:5.81E-9 ID:SGTC_2691|Compound:st077356|FD-Score:3.90|P-value:8.43E-6 ID:SGTC_2968|Compound:9090663|FD-Score:2.87|P-value:7.01E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-5.69|P-value:7.51E-10 ID:SGTC_2995|Compound:9067767|FD-Score:2.82|P-value:8.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:9.69|P-value:2.51E-26 ID:SGTC_3206|Compound:9114350|FD-Score:-3.33|P-value:2.38E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.10|P-value:5.93E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.59|P-value:3.53E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:4.50|P-value:3.63E-7 ID:SGTC_56|Compound:0957-0365|FD-Score:3.81|P-value:1.30E-5 ID:SGTC_57|Compound:miconazole|FD-Score:5.71|P-value:1.99E-10 ID:SGTC_65|Compound:0798-0905|FD-Score:4.76|P-value:8.20E-8 ID:SGTC_199|Compound:4063-0024|FD-Score:2.96|P-value:5.06E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.19|P-value:1.89E-6 ID:SGTC_285|Compound:1486-1325|FD-Score:3.21|P-value:1.86E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:2.82|P-value:8.29E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.58|P-value:3.68E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:4.13|P-value:2.63E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.00|P-value:4.95E-6 ID:SGTC_560|Compound:2332-1943|FD-Score:-4.31|P-value:2.61E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.16|P-value:2.21E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:5.57|P-value:5.07E-10 ID:SGTC_621|Compound:3584-0052|FD-Score:3.14|P-value:2.40E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:2.91|P-value:5.94E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.88|P-value:2.19E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.55|P-value:7.62E-7 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.60|P-value:5.77E-7 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.97|P-value:1.42E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:3.95|P-value:6.45E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:3.07|P-value:3.26E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.27|P-value:1.43E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.18|P-value:4.37E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.26|P-value:3.16E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:2.93|P-value:5.53E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.69|P-value:2.30E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:5.31|P-value:2.86E-9 ID:SGTC_889|Compound:0919-1524|FD-Score:3.06|P-value:3.33E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.07|P-value:3.21E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.57|P-value:8.59E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.96|P-value:9.75E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:3.46|P-value:6.22E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.75|P-value:1.73E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.01|P-value:4.14E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:2.95|P-value:5.24E-4 ID:SGTC_1653|Compound:st012112|FD-Score:4.00|P-value:5.07E-6 ID:SGTC_1761|Compound:st044296|FD-Score:2.94|P-value:5.40E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.03|P-value:3.77E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.01|P-value:4.05E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.66|P-value:2.60E-5 ID:SGTC_2421|Compound:5690543|FD-Score:2.99|P-value:4.45E-4 ID:SGTC_2439|Compound:5492030|FD-Score:7.10|P-value:4.26E-15 ID:SGTC_2441|Compound:5730946|FD-Score:5.05|P-value:1.49E-8 ID:SGTC_2451|Compound:5856223|FD-Score:5.20|P-value:5.81E-9 ID:SGTC_2691|Compound:st077356|FD-Score:3.90|P-value:8.43E-6 ID:SGTC_2968|Compound:9090663|FD-Score:2.87|P-value:7.01E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-5.69|P-value:7.51E-10 ID:SGTC_2995|Compound:9067767|FD-Score:2.82|P-value:8.28E-4 ID:SGTC_3202|Compound:9113761|FD-Score:9.69|P-value:2.51E-26 ID:SGTC_3206|Compound:9114350|FD-Score:-3.33|P-value:2.38E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-3.10|P-value:5.93E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.59|P-value:3.53E-5

Top fitness defect scores for YBR138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3202 9113761 9.69 49.5 µM 2.51E-26 2 1.71E-22
2 SGTC_2439 5492030 7.10 7.2 µM 4.26E-15 1 6.24E-13
3 SGTC_57 miconazole 5.71 162.5 nM 1.99E-10 ergosterol depletion effects on membrane 11 5.81E-9
4 SGTC_563 tetrahydrosecaminediol 5.57 614.0 µM 5.07E-10 amide catabolism 4 1.29E-8
5 SGTC_865 0488-0499 5.31 301.0 µM 2.86E-9 6 5.57E-8
6 SGTC_2451 5856223 5.20 45.7 µM 5.81E-9 5 1.02E-7
7 SGTC_2441 5730946 5.05 39.1 µM 1.49E-8 7 2.26E-7
8 SGTC_65 0798-0905 4.76 35.0 µM 8.20E-8 calcium & mitochondrial duress 57 9.63E-7
9 SGTC_51 1013-0126 4.50 23.4 µM 3.63E-7 22 3.40E-6
10 SGTC_234 nsc-17383 4.19 10.7 µM 1.89E-6 ERG2 20 1.38E-5
11 SGTC_537 1334-0398 4.13 209.0 µM 2.63E-6 20 1.82E-5
12 SGTC_546 peri-Naphthalide 4.00 147.0 µM 4.95E-6 DNA damage response 18 3.11E-5
13 SGTC_1653 st012112 4.00 65.0 µM 5.07E-6 10 3.18E-5
14 SGTC_763 3453-1109 3.95 128.0 µM 6.45E-6 16 3.89E-5
15 SGTC_2691 st077356 3.90 60.2 µM 8.43E-6 29 4.89E-5
16 SGTC_56 0957-0365 3.81 83.2 µM 1.30E-5 Golgi 51 7.07E-5
17 SGTC_1232 0279-0259 3.75 161.0 µM 1.73E-5 23 9.00E-5
18 SGTC_864 0469-0573 3.69 172.0 µM 2.30E-5 27 1.14E-4
19 SGTC_2311 7694451 3.66 200.0 µM 2.60E-5 29 1.27E-4
20 SGTC_3353 9151644 3.59 39.3 µM 3.53E-5 20 1.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 2.63E-42 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.172 1.02E-23 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.127 1.64E-13 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.118 5.81E-12 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.114 3.10E-11 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.111 1.20E-10 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.110 2.01E-10 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.108 3.36E-10 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.106 8.68E-10 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.105 9.46E-10 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.103 2.42E-9 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.102 2.80E-9 YER148W SPT15 het TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
0.102 3.01E-9 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.100 5.71E-9 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.100 6.39E-9 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner