YBR139W

Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR139W / YBR139W

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.76|P-value:1.09E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:16.40|P-value:1.16E-59 ID:SGTC_73|Compound:0327-0325|FD-Score:3.73|P-value:1.20E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.51|P-value:2.78E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.74|P-value:1.51E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.12|P-value:9.48E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.47|P-value:3.26E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.48|P-value:5.17E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:3.56|P-value:2.32E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.42|P-value:3.33E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.20|P-value:1.77E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:3.37|P-value:4.60E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.80|P-value:7.87E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.22|P-value:7.76E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.37|P-value:3.95E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.20|P-value:7.05E-4 ID:SGTC_1518|Compound:st038567|FD-Score:5.82|P-value:4.87E-9 ID:SGTC_1691|Compound:st019933|FD-Score:3.72|P-value:1.26E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.60|P-value:1.66E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.29|P-value:5.13E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.86|P-value:8.42E-7 ID:SGTC_2185|Compound:6113692|FD-Score:-3.51|P-value:2.32E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.82|P-value:8.64E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.30|P-value:1.17E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.72|P-value:1.28E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.53|P-value:4.15E-6 ID:SGTC_2486|Compound:5283202|FD-Score:5.16|P-value:1.85E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.22|P-value:7.86E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.43|P-value:6.52E-6 ID:SGTC_2701|Compound:st077767|FD-Score:-3.65|P-value:1.37E-4 ID:SGTC_2705|Compound:st078069|FD-Score:4.08|P-value:2.96E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.89|P-value:6.50E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-7.81|P-value:4.40E-15 ID:SGTC_2757|Compound:clomiphene|FD-Score:-7.91|P-value:2.11E-15 ID:SGTC_2930|Compound:9013230|FD-Score:-3.59|P-value:1.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.61|P-value:1.61E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.65|P-value:1.65E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.83|P-value:8.21E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.38|P-value:4.49E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.67|P-value:1.53E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.05|P-value:3.35E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.44|P-value:3.00E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.16|P-value:9.39E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:3.76|P-value:1.09E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:16.40|P-value:1.16E-59 ID:SGTC_73|Compound:0327-0325|FD-Score:3.73|P-value:1.20E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.51|P-value:2.78E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.74|P-value:1.51E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.12|P-value:9.48E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.47|P-value:3.26E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.48|P-value:5.17E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:3.56|P-value:2.32E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:-3.42|P-value:3.33E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:4.20|P-value:1.77E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:3.37|P-value:4.60E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.80|P-value:7.87E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.22|P-value:7.76E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.37|P-value:3.95E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.20|P-value:7.05E-4 ID:SGTC_1518|Compound:st038567|FD-Score:5.82|P-value:4.87E-9 ID:SGTC_1691|Compound:st019933|FD-Score:3.72|P-value:1.26E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.60|P-value:1.66E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.29|P-value:5.13E-4 ID:SGTC_2184|Compound:6075246|FD-Score:4.86|P-value:8.42E-7 ID:SGTC_2185|Compound:6113692|FD-Score:-3.51|P-value:2.32E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.82|P-value:8.64E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.30|P-value:1.17E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.72|P-value:1.28E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.53|P-value:4.15E-6 ID:SGTC_2486|Compound:5283202|FD-Score:5.16|P-value:1.85E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.22|P-value:7.86E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.43|P-value:6.52E-6 ID:SGTC_2701|Compound:st077767|FD-Score:-3.65|P-value:1.37E-4 ID:SGTC_2705|Compound:st078069|FD-Score:4.08|P-value:2.96E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.89|P-value:6.50E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-7.81|P-value:4.40E-15 ID:SGTC_2757|Compound:clomiphene|FD-Score:-7.91|P-value:2.11E-15 ID:SGTC_2930|Compound:9013230|FD-Score:-3.59|P-value:1.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.61|P-value:1.61E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.65|P-value:1.65E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.83|P-value:8.21E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.38|P-value:4.49E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.67|P-value:1.53E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.05|P-value:3.35E-5 ID:SGTC_3291|Compound:9121177|FD-Score:-3.44|P-value:3.00E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.16|P-value:9.39E-4

Top fitness defect scores for YBR139W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 16.40 35.0 µM 1.16E-59 calcium & mitochondrial duress 4 5.03E-61
2 SGTC_1518 st038567 5.82 90.8 µM 4.87E-9 4 2.98E-9
3 SGTC_2486 5283202 5.16 22.4 µM 1.85E-7 16 1.24E-7
4 SGTC_2184 6075246 4.86 200.0 µM 8.42E-7 11 5.85E-7
5 SGTC_359 0081-0058 4.74 15.9 µM 1.51E-6 60S ribosome export 24 1.06E-6
6 SGTC_2478 5763493 4.53 32.3 µM 4.15E-6 15 3.00E-6
7 SGTC_608 k048-0125 4.48 159.0 µM 5.17E-6 18 3.76E-6
8 SGTC_2565 isoliquiritigenin 4.43 100.0 µM 6.52E-6 22 4.76E-6
9 SGTC_2307 7538926 4.30 6.3 µM 1.17E-5 28 8.67E-6
10 SGTC_957 1187-1561 4.20 14.1 µM 1.77E-5 15 1.33E-5
11 SGTC_2705 st078069 4.08 42.8 µM 2.96E-5 5 2.24E-5
12 SGTC_3186 9110464 4.05 49.5 µM 3.35E-5 RPP1 & pyrimidine depletion 12 2.55E-5
13 SGTC_2755 lomerizine 3.89 42.7 µM 6.50E-5 26 5.03E-5
14 SGTC_3075 9116269 3.83 49.5 µM 8.21E-5 23 6.39E-5
15 SGTC_2267 7931562 3.82 200.0 µM 8.64E-5 25 6.74E-5
16 SGTC_2 0422-0095 3.76 29.0 µM 1.09E-4 redox potentiating 7 8.58E-5
17 SGTC_73 0327-0325 3.73 16.2 µM 1.20E-4 DNA damage response 56 9.39E-5
18 SGTC_1691 st019933 3.72 84.6 µM 1.26E-4 17 9.95E-5
19 SGTC_2328 6201408 3.72 200.0 µM 1.28E-4 25 1.01E-4
20 SGTC_3138 9097216 3.67 49.5 µM 1.53E-4 20 1.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.260 4.11E-53 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.244 8.39E-47 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.223 5.01E-39 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.197 1.04E-30 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.193 1.72E-29 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.177 6.05E-25 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.175 1.29E-24 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.175 1.89E-24 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.170 3.89E-23 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.166 2.88E-22 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.162 2.94E-21 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.162 4.86E-21 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.158 3.00E-20 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.152 6.69E-19 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.147 1.07E-17 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p