YBR144C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR144C / YBR144C

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:2.97|P-value:4.85E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.91|P-value:6.10E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.50|P-value:3.05E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:3.94|P-value:6.21E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.57|P-value:4.02E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.02|P-value:4.19E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.16|P-value:2.23E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.95|P-value:5.84E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.56|P-value:3.53E-10 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.86|P-value:7.45E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-2.94|P-value:5.72E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.27|P-value:1.43E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.91|P-value:6.19E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.92|P-value:6.76E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:5.82|P-value:5.70E-11 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.44|P-value:6.84E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.97|P-value:4.81E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.63|P-value:2.85E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.35|P-value:1.02E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.64|P-value:2.69E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-2.92|P-value:6.34E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.03|P-value:3.93E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.28|P-value:1.46E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.90|P-value:6.54E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-2.93|P-value:6.15E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.65|P-value:2.61E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.22|P-value:1.75E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.34|P-value:1.07E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.25|P-value:1.54E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.34|P-value:1.14E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.42|P-value:7.26E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.86|P-value:7.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.87|P-value:7.64E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.82|P-value:1.19E-5 ID:SGTC_2788|Compound:5282734|FD-Score:2.86|P-value:7.43E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.52|P-value:4.71E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.66|P-value:2.42E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.30|P-value:1.25E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.33|P-value:7.79E-7 ID:SGTC_3027|Compound:9089541|FD-Score:-2.82|P-value:9.17E-4 ID:SGTC_3053|Compound:9095903|FD-Score:-2.88|P-value:7.23E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.39|P-value:1.17E-9 ID:SGTC_3212|Compound:9128307|FD-Score:3.60|P-value:3.32E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.14|P-value:2.61E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:2.97|P-value:4.85E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.91|P-value:6.10E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.50|P-value:3.05E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:3.94|P-value:6.21E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.57|P-value:4.02E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.02|P-value:4.19E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.16|P-value:2.23E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.95|P-value:5.84E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:5.56|P-value:3.53E-10 ID:SGTC_1022|Compound:4477-0945|FD-Score:2.86|P-value:7.45E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-2.94|P-value:5.72E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.27|P-value:1.43E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:2.91|P-value:6.19E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.92|P-value:6.76E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:5.82|P-value:5.70E-11 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.44|P-value:6.84E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:2.97|P-value:4.81E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.63|P-value:2.85E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.35|P-value:1.02E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.64|P-value:2.69E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-2.92|P-value:6.34E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.03|P-value:3.93E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.28|P-value:1.46E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.90|P-value:6.54E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-2.93|P-value:6.15E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.65|P-value:2.61E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.22|P-value:1.75E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.34|P-value:1.07E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.25|P-value:1.54E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.34|P-value:1.14E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.42|P-value:7.26E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.86|P-value:7.53E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.87|P-value:7.64E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.82|P-value:1.19E-5 ID:SGTC_2788|Compound:5282734|FD-Score:2.86|P-value:7.43E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.52|P-value:4.71E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.66|P-value:2.42E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.30|P-value:1.25E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.33|P-value:7.79E-7 ID:SGTC_3027|Compound:9089541|FD-Score:-2.82|P-value:9.17E-4 ID:SGTC_3053|Compound:9095903|FD-Score:-2.88|P-value:7.23E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.39|P-value:1.17E-9 ID:SGTC_3212|Compound:9128307|FD-Score:3.60|P-value:3.32E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.14|P-value:2.61E-4

Top fitness defect scores for YBR144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1302 1159-0335 5.82 255.0 µM 5.70E-11 1 3.02E-9
2 SGTC_1007 4101-0031 5.56 70.0 µM 3.53E-10 3 1.35E-8
3 SGTC_3202 9113761 5.39 49.5 µM 1.17E-9 15 3.58E-8
4 SGTC_358 0075-0058 4.50 9.4 µM 3.05E-7 42 3.43E-6
5 SGTC_2989 9073649 4.33 71.4 µM 7.79E-7 25 7.42E-6
6 SGTC_957 1187-1561 3.95 14.1 µM 5.84E-6 18 3.88E-5
7 SGTC_426 0988-0037 3.94 14.6 µM 6.21E-6 ERAD & cell cycle 32 4.08E-5
8 SGTC_1184 1269-1718 3.92 139.0 µM 6.76E-6 29 4.37E-5
9 SGTC_2837 9008476 3.66 45.5 µM 2.42E-5 45 1.25E-4
10 SGTC_2251 lansoprazole 3.65 556.0 µM 2.61E-5 28 1.33E-4
11 SGTC_1856 st057054 3.64 55.7 µM 2.69E-5 34 1.36E-4
12 SGTC_1604 st002052 3.63 72.4 µM 2.85E-5 TSC3-RPN4 34 1.43E-4
13 SGTC_3212 9128307 3.60 49.5 µM 3.32E-5 63 1.62E-4
14 SGTC_2816 7982706 3.52 58.4 µM 4.71E-5 azole & statin 68 2.16E-4
15 SGTC_1309 pyrazolanthrone 3.44 13.4 µM 6.84E-5 33 2.94E-4
16 SGTC_2602 kawain 3.42 100.0 µM 7.26E-5 46 3.09E-4
17 SGTC_1851 st056236 3.35 18.9 µM 1.02E-4 32 4.09E-4
18 SGTC_2432 5630864 3.34 12.2 µM 1.07E-4 52 4.25E-4
19 SGTC_2917 7979103 3.30 53.8 µM 1.25E-4 58 4.83E-4
20 SGTC_1119 parthenolide 3.27 318.5 nM 1.43E-4 TSC3-RPN4 76 5.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.51E-14 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.123 7.94E-13 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.114 3.93E-11 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.113 5.24E-11 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.112 8.36E-11 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.106 6.61E-10 YGR109C CLB6 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.105 9.14E-10 YCL025C AGP1 hom Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.099 9.14E-9 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.099 1.00E-8 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.098 1.33E-8 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.097 1.58E-8 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.096 2.59E-8 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.095 3.72E-8 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.094 4.39E-8 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.092 1.06E-7 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene