HIPHOP chemogenomics database

YBR144C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR144C / YBR144C

Click on Significant Values for Screen Details

Top fitness defect scores for YBR144C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1302	1159-0335	5.82	255.0 µM	5.70E-11		1	3.02E-9
2	SGTC_1007	4101-0031	5.56	70.0 µM	3.53E-10		3	1.35E-8
3	SGTC_3202	9113761	5.39	49.5 µM	1.17E-9		15	3.58E-8
4	SGTC_358	0075-0058	4.50	9.4 µM	3.05E-7		42	3.43E-6
5	SGTC_2989	9073649	4.33	71.4 µM	7.79E-7		25	7.42E-6
6	SGTC_957	1187-1561	3.95	14.1 µM	5.84E-6		18	3.88E-5
7	SGTC_426	0988-0037	3.94	14.6 µM	6.21E-6	ERAD & cell cycle	32	4.08E-5
8	SGTC_1184	1269-1718	3.92	139.0 µM	6.76E-6		29	4.37E-5
9	SGTC_2837	9008476	3.66	45.5 µM	2.42E-5		45	1.25E-4
10	SGTC_2251	lansoprazole	3.65	556.0 µM	2.61E-5		28	1.33E-4
11	SGTC_1856	st057054	3.64	55.7 µM	2.69E-5		34	1.36E-4
12	SGTC_1604	st002052	3.63	72.4 µM	2.85E-5	TSC3-RPN4	34	1.43E-4
13	SGTC_3212	9128307	3.60	49.5 µM	3.32E-5		63	1.62E-4
14	SGTC_2816	7982706	3.52	58.4 µM	4.71E-5	azole & statin	68	2.16E-4
15	SGTC_1309	pyrazolanthrone	3.44	13.4 µM	6.84E-5		33	2.94E-4
16	SGTC_2602	kawain	3.42	100.0 µM	7.26E-5		46	3.09E-4
17	SGTC_1851	st056236	3.35	18.9 µM	1.02E-4		32	4.09E-4
18	SGTC_2432	5630864	3.34	12.2 µM	1.07E-4		52	4.25E-4
19	SGTC_2917	7979103	3.30	53.8 µM	1.25E-4		58	4.83E-4
20	SGTC_1119	parthenolide	3.27	318.5 nM	1.43E-4	TSC3-RPN4	76	5.40E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.129	6.51E-14	YBL068W	PRS4	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.123	7.94E-13	YIL107C	PFK26	hom	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.114	3.93E-11	YDR420W	HKR1	hom	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.113	5.24E-11	YFL048C	EMP47	hom	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.112	8.36E-11	YHR131C_p	YHR131C_p	hom	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.106	6.61E-10	YGR109C	CLB6	hom	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
0.105	9.14E-10	YCL025C	AGP1	hom	Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.099	9.14E-9	YOR291W	YPK9	hom	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.099	1.00E-8	YNL129W	NRK1	hom	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.098	1.33E-8	YLR237W	THI7	hom	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.097	1.58E-8	YHL007C	STE20	hom	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.096	2.59E-8	YJR115W_p	YJR115W_p	hom	Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.095	3.72E-8	YHL003C	LAG1	hom	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.094	4.39E-8	YPL036W	PMA2	hom	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.092	1.06E-7	YBR138C_p	YBR138C_p	hom	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene