YBR150C / TBS1

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR150C / TBS1

Click on Significant Values for Screen Details ID:SGTC_227|Compound:fluconazole|FD-Score:4.43|P-value:5.39E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:2.95|P-value:5.78E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.10|P-value:3.27E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.46|P-value:6.83E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.35|P-value:1.15E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-2.94|P-value:6.03E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.14|P-value:2.71E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.66|P-value:2.80E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.92|P-value:6.60E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.84|P-value:1.20E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.90|P-value:3.38E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.29|P-value:1.48E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:2.88|P-value:7.71E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:2.94|P-value:6.15E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.07|P-value:3.56E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.70|P-value:1.15E-7 ID:SGTC_1727|Compound:st034309|FD-Score:4.18|P-value:2.14E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-4.64|P-value:1.63E-7 ID:SGTC_1925|Compound:st057770|FD-Score:-4.58|P-value:2.26E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.85|P-value:1.14E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.55|P-value:4.73E-5 ID:SGTC_1980|Compound:st071811|FD-Score:-2.84|P-value:8.73E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.56|P-value:4.41E-5 ID:SGTC_2023|Compound:5144124|FD-Score:3.34|P-value:1.16E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.85|P-value:1.10E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-2.87|P-value:7.92E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.94|P-value:6.16E-4 ID:SGTC_2164|Compound:5685496|FD-Score:2.92|P-value:6.41E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.68|P-value:2.52E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.40|P-value:1.41E-9 ID:SGTC_2691|Compound:st077356|FD-Score:3.98|P-value:5.99E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-3.56|P-value:4.47E-5 ID:SGTC_2703|Compound:st077852|FD-Score:4.16|P-value:2.36E-6 ID:SGTC_2799|Compound:7812892|FD-Score:3.12|P-value:2.91E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.01|P-value:4.56E-4 ID:SGTC_2922|Compound:7999257|FD-Score:2.85|P-value:8.68E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.52|P-value:5.27E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-2.89|P-value:7.30E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.84|P-value:1.21E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.02|P-value:4.50E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-2.94|P-value:6.13E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.61|P-value:3.51E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.83|P-value:1.27E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:4.43|P-value:5.39E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:2.95|P-value:5.78E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.10|P-value:3.27E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.46|P-value:6.83E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.35|P-value:1.15E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-2.94|P-value:6.03E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.14|P-value:2.71E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.66|P-value:2.80E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.92|P-value:6.60E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.84|P-value:1.20E-5 ID:SGTC_1299|Compound:1079-1439|FD-Score:4.90|P-value:3.38E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.29|P-value:1.48E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:2.88|P-value:7.71E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:2.94|P-value:6.15E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.07|P-value:3.56E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.70|P-value:1.15E-7 ID:SGTC_1727|Compound:st034309|FD-Score:4.18|P-value:2.14E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-4.64|P-value:1.63E-7 ID:SGTC_1925|Compound:st057770|FD-Score:-4.58|P-value:2.26E-7 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.85|P-value:1.14E-5 ID:SGTC_1962|Compound:st076595|FD-Score:-3.55|P-value:4.73E-5 ID:SGTC_1980|Compound:st071811|FD-Score:-2.84|P-value:8.73E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.56|P-value:4.41E-5 ID:SGTC_2023|Compound:5144124|FD-Score:3.34|P-value:1.16E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.85|P-value:1.10E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-2.87|P-value:7.92E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.94|P-value:6.16E-4 ID:SGTC_2164|Compound:5685496|FD-Score:2.92|P-value:6.41E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.68|P-value:2.52E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.40|P-value:1.41E-9 ID:SGTC_2691|Compound:st077356|FD-Score:3.98|P-value:5.99E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-3.56|P-value:4.47E-5 ID:SGTC_2703|Compound:st077852|FD-Score:4.16|P-value:2.36E-6 ID:SGTC_2799|Compound:7812892|FD-Score:3.12|P-value:2.91E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.01|P-value:4.56E-4 ID:SGTC_2922|Compound:7999257|FD-Score:2.85|P-value:8.68E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.52|P-value:5.27E-5 ID:SGTC_3089|Compound:9117425|FD-Score:-2.89|P-value:7.30E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.84|P-value:1.21E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.02|P-value:4.50E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-2.94|P-value:6.13E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.61|P-value:3.51E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.83|P-value:1.27E-5

Top fitness defect scores for YBR150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1299 1079-1439 4.90 3.7 µM 3.38E-8 TSC3-RPN4 3 4.72E-7
2 SGTC_227 fluconazole 4.43 33.5 µM 5.39E-7 azole & statin 66 4.71E-6
3 SGTC_1727 st034309 4.18 9.9 µM 2.14E-6 28 1.48E-5
4 SGTC_2703 st077852 4.16 53.4 µM 2.36E-6 15 1.61E-5
5 SGTC_2691 st077356 3.98 60.2 µM 5.99E-6 27 3.49E-5
6 SGTC_2055 5235184 3.85 200.0 µM 1.10E-5 ERG2 36 5.79E-5
7 SGTC_1929 genistein trimethyl ether 3.85 50.5 µM 1.14E-5 16 5.95E-5
8 SGTC_3170 9103054 3.84 49.5 µM 1.21E-5 60S ribosome export 14 6.26E-5
9 SGTC_3304 9125678 3.83 46.1 µM 1.27E-5 55 6.51E-5
10 SGTC_2411 st077133 3.68 39.9 µM 2.52E-5 RNA pol III & RNase P/MRP 38 1.15E-4
11 SGTC_999 4022-0066 3.66 22.7 µM 2.80E-5 Golgi 57 1.26E-4
12 SGTC_3085 9117376 3.52 49.5 µM 5.27E-5 22 2.14E-4
13 SGTC_657 3534-0529 3.35 86.7 µM 1.15E-4 29 4.11E-4
14 SGTC_2023 5144124 3.34 124.0 µM 1.16E-4 39 4.13E-4
15 SGTC_1371 2421-0008 3.29 32.7 µM 1.48E-4 mitochondrial processes 72 5.05E-4
16 SGTC_2799 7812892 3.12 81.8 µM 2.91E-4 superoxide 62 8.90E-4
17 SGTC_642 0335-0876 3.10 158.0 µM 3.27E-4 ubiquinone biosynthesis & proteasome 73 9.82E-4
18 SGTC_3192 9110362 3.02 49.5 µM 4.50E-4 mitochondrial processes 40 0.00128
19 SGTC_2816 7982706 3.01 58.4 µM 4.56E-4 azole & statin 104 0.00130
20 SGTC_266 formosanin C 2.95 406.0 nM 5.78E-4 sphingolipid biosynthesis & PDR1 124 0.00158

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.38E-15 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.134 6.06E-15 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.127 1.37E-13 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.125 3.48E-13 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.120 3.59E-12 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.119 4.69E-12 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.111 1.07E-10 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.109 2.93E-10 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.103 2.10E-9 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.099 9.74E-9 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.097 1.80E-8 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.12E-8 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.094 5.38E-8 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.093 7.35E-8 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.090 1.56E-7 YGL065C ALG2 het Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol