YBR153W / RIB7

Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR153W / RIB7

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.08|P-value:3.57E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.44|P-value:5.10E-7 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.02|P-value:4.41E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.28|P-value:1.56E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.43|P-value:8.08E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:6.03|P-value:1.69E-11 ID:SGTC_665|Compound:3914-0008|FD-Score:2.96|P-value:5.74E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.88|P-value:7.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.24|P-value:1.84E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.97|P-value:5.48E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.28|P-value:1.51E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.92|P-value:8.18E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.21|P-value:2.05E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.89|P-value:7.55E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.01|P-value:5.08E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.24|P-value:1.52E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.43|P-value:8.02E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.91|P-value:6.81E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.93|P-value:6.29E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.13|P-value:2.93E-4 ID:SGTC_2128|Compound:5255449|FD-Score:2.87|P-value:7.96E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.23|P-value:1.89E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.27|P-value:1.59E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.70|P-value:2.39E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.09|P-value:3.51E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.35|P-value:1.12E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.11|P-value:3.07E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:6.18|P-value:5.49E-12 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.27|P-value:1.32E-6 ID:SGTC_2797|Compound:7859098|FD-Score:3.72|P-value:2.15E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.56|P-value:4.40E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.02|P-value:4.41E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.91|P-value:8.64E-6 ID:SGTC_3256|Compound:9138902|FD-Score:-3.15|P-value:2.61E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.08|P-value:3.57E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.44|P-value:5.10E-7 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.02|P-value:4.41E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.28|P-value:1.56E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.43|P-value:8.08E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:6.03|P-value:1.69E-11 ID:SGTC_665|Compound:3914-0008|FD-Score:2.96|P-value:5.74E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.88|P-value:7.62E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.24|P-value:1.84E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.97|P-value:5.48E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.28|P-value:1.51E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.92|P-value:8.18E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.21|P-value:2.05E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.89|P-value:7.55E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.01|P-value:5.08E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.24|P-value:1.52E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.43|P-value:8.02E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.91|P-value:6.81E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.93|P-value:6.29E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.13|P-value:2.93E-4 ID:SGTC_2128|Compound:5255449|FD-Score:2.87|P-value:7.96E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.23|P-value:1.89E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.27|P-value:1.59E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.70|P-value:2.39E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.09|P-value:3.51E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.35|P-value:1.12E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.11|P-value:3.07E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:6.18|P-value:5.49E-12 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.27|P-value:1.32E-6 ID:SGTC_2797|Compound:7859098|FD-Score:3.72|P-value:2.15E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.56|P-value:4.40E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.02|P-value:4.41E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.91|P-value:8.64E-6 ID:SGTC_3256|Compound:9138902|FD-Score:-3.15|P-value:2.61E-4

Top fitness defect scores for YBR153W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2769 toremifene 6.18 3.7 µM 5.49E-12 2 3.30E-10 1.71
2 SGTC_619 1652-1634 6.03 108.0 µM 1.69E-11 PDR1 2 8.36E-10 0.81
3 SGTC_2770 toltrazuril 4.27 17.5 µM 1.32E-6 2 9.75E-6 0.21
4 SGTC_1132 3456-3614 4.24 2.5 µM 1.52E-6 tubulin folding & SWR complex 10 1.10E-5 0.43
5 SGTC_943 3253-1379 3.92 105.0 µM 8.18E-6 8 4.47E-5 0.28
6 SGTC_2797 7859098 3.72 81.8 µM 2.15E-5 9 1.00E-4 0.15
7 SGTC_2588 indole-3-carbinol 3.70 100.0 µM 2.39E-5 11 1.09E-4 0.04
8 SGTC_2799 7812892 3.56 81.8 µM 4.40E-5 superoxide 23 1.82E-4 8.85E-4
9 SGTC_1544 7-methoxy-4-methylcoumarin 3.43 105.0 µM 8.02E-5 10 3.01E-4 0.01
10 SGTC_938 3126-1755 3.28 342.0 µM 1.51E-4 5 5.11E-4 0.11
11 SGTC_2144 5628481 3.23 200.0 µM 1.89E-4 ERG2 6 6.15E-4 0.13
12 SGTC_1941 st076221 3.13 61.8 µM 2.93E-4 sphingolipid biosynthesis & PDR1 23 8.88E-4 0.06
13 SGTC_2767 sibutramine 3.11 71.5 µM 3.07E-4 4 9.24E-4 0.03
14 SGTC_36 0335-0881 3.08 14.2 µM 3.57E-4 ubiquinone biosynthesis & proteasome 50 0.00105 0.03
15 SGTC_491 tetrandrine 3.02 80.3 µM 4.41E-4 9 0.00125 0.01
16 SGTC_2810 7959871 3.02 45.5 µM 4.41E-4 copper-dependent oxidative stress 26 0.00125 0.03
17 SGTC_933 2914-0560 2.97 114.0 µM 5.48E-4 20 0.00150 0.05
18 SGTC_665 3914-0008 2.96 307.0 µM 5.74E-4 11 0.00156 0.01
19 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.93 70.1 µM 6.29E-4 17 0.00168 0.07
20 SGTC_1913 st060213 2.91 96.1 µM 6.81E-4 10 0.00180 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 7.32E-17 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.139 6.62E-16 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.124 4.51E-13 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.121 1.69E-12 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.117 1.23E-11 YBR088C POL30 het Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.115 2.35E-11 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.105 9.01E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.104 1.50E-9 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.104 1.70E-9 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.104 1.72E-9 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.103 2.00E-9 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
0.102 3.13E-9 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.101 3.90E-9 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.101 4.39E-9 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.098 1.24E-8 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)