YBR162W-A / YSY6

Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR162W-A / YSY6

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.00|P-value:5.91E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.87|P-value:6.72E-8 ID:SGTC_113|Compound:0099-0221|FD-Score:3.31|P-value:1.69E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.07|P-value:5.28E-6 ID:SGTC_202|Compound:3594-0513|FD-Score:2.91|P-value:8.04E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:2.93|P-value:7.41E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-2.88|P-value:9.36E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.09|P-value:4.31E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.18|P-value:2.85E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.06|P-value:4.62E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.58|P-value:5.23E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.86|P-value:1.43E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.26|P-value:6.14E-12 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.09|P-value:4.23E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.04|P-value:5.05E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.19|P-value:2.79E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.10|P-value:3.96E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-2.90|P-value:8.59E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.94|P-value:1.02E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:-4.00|P-value:7.70E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.41|P-value:1.10E-4 ID:SGTC_1558|Compound:st069300|FD-Score:2.90|P-value:8.59E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.22|P-value:2.46E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.86|P-value:1.49E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.57|P-value:5.65E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.35|P-value:1.46E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.56|P-value:4.03E-7 ID:SGTC_2127|Compound:5253358|FD-Score:4.43|P-value:8.28E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.50|P-value:7.57E-5 ID:SGTC_2136|Compound:5328288|FD-Score:5.34|P-value:3.87E-9 ID:SGTC_2240|Compound:6690706|FD-Score:-3.24|P-value:2.38E-4 ID:SGTC_2381|Compound:9035592|FD-Score:2.87|P-value:9.50E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.03|P-value:5.40E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.91|P-value:8.09E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.34|P-value:1.50E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.57|P-value:5.46E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.84|P-value:8.74E-8 ID:SGTC_2804|Compound:7954240|FD-Score:3.84|P-value:1.65E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.53|P-value:6.53E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.26|P-value:2.08E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.33|P-value:1.35E-6 ID:SGTC_3302|Compound:9125395|FD-Score:-3.27|P-value:2.06E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.00|P-value:5.91E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.87|P-value:6.72E-8 ID:SGTC_113|Compound:0099-0221|FD-Score:3.31|P-value:1.69E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:4.07|P-value:5.28E-6 ID:SGTC_202|Compound:3594-0513|FD-Score:2.91|P-value:8.04E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:2.93|P-value:7.41E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-2.88|P-value:9.36E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.09|P-value:4.31E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.18|P-value:2.85E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.06|P-value:4.62E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.58|P-value:5.23E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.86|P-value:1.43E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.26|P-value:6.14E-12 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.09|P-value:4.23E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.04|P-value:5.05E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.19|P-value:2.79E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.10|P-value:3.96E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-2.90|P-value:8.59E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-2.89|P-value:9.03E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.94|P-value:1.02E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:-4.00|P-value:7.70E-6 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.41|P-value:1.10E-4 ID:SGTC_1558|Compound:st069300|FD-Score:2.90|P-value:8.59E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.22|P-value:2.46E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.86|P-value:1.49E-5 ID:SGTC_1935|Compound:st074532|FD-Score:3.57|P-value:5.65E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.35|P-value:1.46E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.56|P-value:4.03E-7 ID:SGTC_2127|Compound:5253358|FD-Score:4.43|P-value:8.28E-7 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.50|P-value:7.57E-5 ID:SGTC_2136|Compound:5328288|FD-Score:5.34|P-value:3.87E-9 ID:SGTC_2240|Compound:6690706|FD-Score:-3.24|P-value:2.38E-4 ID:SGTC_2381|Compound:9035592|FD-Score:2.87|P-value:9.50E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.03|P-value:5.40E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.91|P-value:8.09E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.34|P-value:1.50E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.57|P-value:5.46E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.84|P-value:8.74E-8 ID:SGTC_2804|Compound:7954240|FD-Score:3.84|P-value:1.65E-5 ID:SGTC_2809|Compound:7964133|FD-Score:3.53|P-value:6.53E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.26|P-value:2.08E-4 ID:SGTC_3013|Compound:9080133|FD-Score:4.33|P-value:1.35E-6 ID:SGTC_3302|Compound:9125395|FD-Score:-3.27|P-value:2.06E-4

Top fitness defect scores for YBR162W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_922 1866-0035 6.26 480.0 µM 6.14E-12 excess fatty acid 18 1.88E-10
2 SGTC_2136 5328288 5.34 199.3 µM 3.87E-9 5 4.75E-8
3 SGTC_46 0329-0187a 4.87 2.2 µM 6.72E-8 41 5.51E-7
4 SGTC_2126 5251174 4.56 33.9 µM 4.03E-7 17 2.57E-6
5 SGTC_2127 5253358 4.43 187.9 µM 8.28E-7 17 4.77E-6
6 SGTC_3013 9080133 4.33 71.4 µM 1.35E-6 16 7.29E-6
7 SGTC_164 4100-3994 4.07 89.6 µM 5.28E-6 28 2.35E-5
8 SGTC_1401 3807-4679 3.94 7.6 µM 1.02E-5 tubulin folding & SWR complex 19 4.13E-5
9 SGTC_784 4579-0127 3.86 173.0 µM 1.43E-5 23 5.56E-5
10 SGTC_1924 st058459 3.86 75.1 µM 1.49E-5 12 5.75E-5
11 SGTC_2804 7954240 3.84 19.5 µM 1.65E-5 35 6.26E-5
12 SGTC_777 1315-0167 3.58 517.0 µM 5.23E-5 Golgi 38 1.69E-4
13 SGTC_2568 diosmetin 3.57 100.0 µM 5.46E-5 35 1.76E-4
14 SGTC_1935 st074532 3.57 41.6 µM 5.65E-5 46 1.81E-4
15 SGTC_2809 7964133 3.53 13.0 µM 6.53E-5 60S ribosome export 58 2.05E-4
16 SGTC_2130 NSC 7 3.50 2.5 µM 7.57E-5 copper-dependent oxidative stress 50 2.33E-4
17 SGTC_1460 k062-0059 3.41 9.2 µM 1.10E-4 Golgi 31 3.22E-4
18 SGTC_2060 5238662 3.35 140.0 µM 1.46E-4 45 4.10E-4
19 SGTC_2524 avocatin b 3.34 10.6 µM 1.50E-4 40 4.21E-4
20 SGTC_113 0099-0221 3.31 2.5 µM 1.69E-4 55 4.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.65E-16 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.132 1.66E-14 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.127 1.31E-13 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.119 5.21E-12 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.116 1.34E-11 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.116 1.56E-11 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.113 6.44E-11 YMR069W NAT4 hom N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
0.106 8.57E-10 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.098 1.25E-8 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.096 2.58E-8 YNL159C ASI2 hom Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
0.095 3.33E-8 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.093 6.25E-8 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.092 1.06E-7 YOL154W ZPS1 hom Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
0.092 1.09E-7 YDR383C NKP1 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4
0.090 1.75E-7 YGL132W_d YGL132W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C