YBR169C / SSE2

Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR169C / SSE2

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:-3.12|P-value:4.16E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.03|P-value:3.17E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:6.08|P-value:6.20E-12 ID:SGTC_67|Compound:0335-0847|FD-Score:4.18|P-value:1.36E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.37|P-value:7.44E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:2.88|P-value:5.52E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.06|P-value:5.21E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.81|P-value:7.26E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.74|P-value:2.89E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.06|P-value:5.18E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.95|P-value:8.04E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.05|P-value:6.25E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:3.09|P-value:2.41E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.50|P-value:8.62E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.44|P-value:1.10E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.67|P-value:3.89E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.13|P-value:3.94E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:-3.12|P-value:4.16E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.03|P-value:3.17E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:6.08|P-value:6.20E-12 ID:SGTC_67|Compound:0335-0847|FD-Score:4.18|P-value:1.36E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:3.37|P-value:7.44E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:2.88|P-value:5.52E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.06|P-value:5.21E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.81|P-value:7.26E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.74|P-value:2.89E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.06|P-value:5.18E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-2.95|P-value:8.04E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-4.05|P-value:6.25E-6 ID:SGTC_1529|Compound:apigenin|FD-Score:3.09|P-value:2.41E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.50|P-value:8.62E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.44|P-value:1.10E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.67|P-value:3.89E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.13|P-value:3.94E-4

Top fitness defect scores for YBR169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 6.08 35.0 µM 6.20E-12 calcium & mitochondrial duress 30 6.07E-10
2 SGTC_67 0335-0847 4.18 266.0 µM 1.36E-6 ubiquinone biosynthesis & proteasome 104 1.43E-5
3 SGTC_358 0075-0058 3.37 9.4 µM 7.44E-5 97 3.80E-4
4 SGTC_1529 apigenin 3.09 74.0 µM 2.41E-4 75 9.93E-4
5 SGTC_30 5-(2-thienylidene)-Rhodanine 3.03 28.7 µM 3.17E-4 19 0.00124
6 SGTC_968 1309-0633 2.88 340.0 µM 5.52E-4 56 0.00196
7 SGTC_1216 1165-0504 2.81 9.7 µM 7.26E-4 64 0.00245
8 SGTC_1779 st039427 2.67 55.0 µM 0.00126 125 0.00384
9 SGTC_1 0258-0098 2.66 57.4 µM 0.00126 heme biosynthesis & mitochondrial translocase 63 0.00385
10 SGTC_33 0986-0033 2.64 35.8 µM 0.00139 calcium & mitochondrial duress 79 0.00418
11 SGTC_844 0330-0132 2.63 15.3 µM 0.00146 72 0.00433
12 SGTC_532 1548-0774 2.57 215.0 µM 0.00177 101 0.00507
13 SGTC_1207 2099-0101 2.56 141.0 µM 0.00185 107 0.00527
14 SGTC_2491 paeonol 2.53 100.0 µM 0.00203 61 0.00568
15 SGTC_1742 st038235 2.52 28.9 µM 0.00211 mitochondrial stress 229 0.00588
16 SGTC_3292 9120825 2.50 59.8 µM 0.00222 103 0.00613
17 SGTC_1647 st011722 2.47 22.4 µM 0.00251 90 0.00676
18 SGTC_2493 resveratrol 2.46 26.1 µM 0.00255 80 0.00686
19 SGTC_3125 9127534 2.40 49.5 µM 0.00316 78 0.00817
20 SGTC_38 0929-0051 2.34 58.3 µM 0.00383 156 0.00956

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 4.13E-71 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.245 4.66E-47 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.244 8.39E-47 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.227 1.43E-40 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.221 2.23E-38 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.210 1.23E-34 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.204 8.00E-33 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.182 2.75E-26 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.176 7.47E-25 YLR003C CMS1 hom Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.176 1.06E-24 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.168 9.33E-23 YHR047C AAP1 hom Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication
0.166 2.92E-22 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.165 7.15E-22 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.164 9.73E-22 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.164 1.06E-21 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover