YBR178W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR178W / YBR178W

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:4.02|P-value:4.54E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.10|P-value:3.13E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-4.45|P-value:7.22E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:-4.25|P-value:1.69E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.87|P-value:8.24E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.18|P-value:2.41E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.32|P-value:6.29E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.53|P-value:5.16E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:4.54|P-value:5.06E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.17|P-value:9.72E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.99|P-value:5.62E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.24|P-value:8.28E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.20|P-value:9.33E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.34|P-value:5.85E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.46|P-value:3.82E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.15|P-value:2.74E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.33|P-value:5.98E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.34|P-value:5.61E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.10|P-value:3.34E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.42|P-value:4.36E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.64|P-value:1.90E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.23|P-value:7.96E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.74|P-value:1.36E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.28|P-value:6.90E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.23|P-value:8.46E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-4.33|P-value:1.22E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.43|P-value:4.04E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.28|P-value:7.23E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.90|P-value:7.46E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.75|P-value:1.33E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.46|P-value:5.38E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.44|P-value:4.14E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.21|P-value:1.84E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.25|P-value:7.54E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.92|P-value:6.97E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:4.74E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.80|P-value:1.09E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.30|P-value:6.59E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.60|P-value:2.20E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.93|P-value:6.55E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.09|P-value:3.52E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.89|P-value:7.65E-5 ID:SGTC_3019|Compound:9081971|FD-Score:-4.59|P-value:3.85E-6 ID:SGTC_3275|Compound:9138069|FD-Score:-3.77|P-value:1.17E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.37|P-value:5.07E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.72|P-value:1.41E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:4.02|P-value:4.54E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.10|P-value:3.13E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-4.45|P-value:7.22E-6 ID:SGTC_106|Compound:0092-0003|FD-Score:-4.25|P-value:1.69E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:3.87|P-value:8.24E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.18|P-value:2.41E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.32|P-value:6.29E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:4.53|P-value:5.16E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:4.54|P-value:5.06E-6 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.17|P-value:9.72E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.99|P-value:5.62E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.24|P-value:8.28E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.20|P-value:9.33E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.34|P-value:5.85E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.46|P-value:3.82E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.15|P-value:2.74E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.33|P-value:5.98E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:-3.34|P-value:5.61E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.10|P-value:3.34E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.42|P-value:4.36E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.64|P-value:1.90E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.23|P-value:7.96E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.74|P-value:1.36E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.28|P-value:6.90E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.23|P-value:8.46E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-4.33|P-value:1.22E-5 ID:SGTC_2379|Compound:9035213|FD-Score:-3.43|P-value:4.04E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.28|P-value:7.23E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.90|P-value:7.46E-5 ID:SGTC_2468|Compound:5987765|FD-Score:3.75|P-value:1.33E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:5.46|P-value:5.38E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.44|P-value:4.14E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-5.21|P-value:1.84E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.25|P-value:7.54E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.92|P-value:6.97E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:4.74E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.80|P-value:1.09E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.30|P-value:6.59E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.60|P-value:2.20E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.93|P-value:6.55E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.73|P-value:1.43E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.09|P-value:3.52E-5 ID:SGTC_2939|Compound:9044578|FD-Score:3.89|P-value:7.65E-5 ID:SGTC_3019|Compound:9081971|FD-Score:-4.59|P-value:3.85E-6 ID:SGTC_3275|Compound:9138069|FD-Score:-3.77|P-value:1.17E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.37|P-value:5.07E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.72|P-value:1.41E-4

Top fitness defect scores for YBR178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2498 4'-Methoxychalcone 5.46 54.6 µM 5.38E-8 RPP1 & pyrimidine depletion 8 2.37E-8
2 SGTC_746 1095-0025 4.54 46.6 µM 5.06E-6 RSC & ERG11 9 2.84E-6
3 SGTC_720 r052-1644 4.53 49.9 µM 5.16E-6 TSC3-RPN4 20 2.90E-6
4 SGTC_122 0236-0016 4.18 402.4 µM 2.41E-5 RNA processing & uracil transport 26 1.47E-5
5 SGTC_1297 1068-0111 4.15 14.1 µM 2.74E-5 7 1.68E-5
6 SGTC_1494 4358-1428 4.10 177.0 µM 3.34E-5 20 2.07E-5
7 SGTC_2935 9038016 4.09 30.0 µM 3.52E-5 17 2.19E-5
8 SGTC_89 0302-0250 4.02 142.1 µM 4.54E-5 17 2.86E-5
9 SGTC_2825 7998094 3.93 58.4 µM 6.55E-5 fatty acid desaturase (OLE1) 31 4.21E-5
10 SGTC_2532 xanthone 3.92 78.9 µM 6.97E-5 31 4.49E-5
11 SGTC_2402 5553605 3.90 200.0 µM 7.46E-5 29 4.82E-5
12 SGTC_2939 9044578 3.89 71.4 µM 7.65E-5 42 4.96E-5
13 SGTC_108 0509-0257 3.87 621.1 µM 8.24E-5 53 5.35E-5
14 SGTC_2566 crystal violet carbinol 3.80 226.0 nM 1.09E-4 44 7.20E-5
15 SGTC_121 0557-0495 3.77 61.3 µM 1.22E-4 calcium & mitochondrial duress 65 8.10E-5
16 SGTC_2468 5987765 3.75 72.9 µM 1.33E-4 19 8.86E-5
17 SGTC_1950 st077106 3.74 7.2 µM 1.36E-4 RNA processing & uracil transport 37 9.10E-5
18 SGTC_2934 9036370 3.73 36.9 µM 1.43E-4 41 9.56E-5
19 SGTC_1278 0874-0585 3.46 172.0 µM 3.82E-4 25 2.69E-4
20 SGTC_2499 avocadenofuran 3.44 51.5 µM 4.14E-4 57 2.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.61E-10 YJR076C CDC11 het Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
0.089 2.08E-7 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.077 7.36E-6 YLR422W_p YLR422W_p hom Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
0.077 8.00E-6 YOL101C IZH4 hom Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress
0.077 8.50E-6 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.071 3.58E-5 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.069 5.95E-5 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.069 6.00E-5 YMR105W-A_p YMR105W-A_p hom Putative protein of unknown function
0.069 6.69E-5 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.069 6.71E-5 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.067 1.12E-4 YJL103C GSM1 hom Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
0.066 1.35E-4 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.066 1.42E-4 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.066 1.45E-4 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.064 2.00E-4 YOR325W_d YOR325W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1