YBR181C / RPS6B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR181C / RPS6B

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.68|P-value:8.05E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.33|P-value:3.09E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.14|P-value:7.19E-4 ID:SGTC_406|Compound:estrone|FD-Score:4.58|P-value:1.68E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.06|P-value:9.63E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:9.70E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.20|P-value:5.89E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.08|P-value:9.05E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.18|P-value:5.47E-8 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.38|P-value:3.10E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.07|P-value:1.81E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.89|P-value:3.92E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.47|P-value:2.13E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.23|P-value:4.57E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.51|P-value:1.86E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.31|P-value:4.03E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.41|P-value:2.34E-14 ID:SGTC_1993|Compound:st073995|FD-Score:3.15|P-value:7.15E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.06|P-value:8.17E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.39|P-value:2.93E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.08|P-value:7.64E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_2357|Compound:9067248|FD-Score:-3.12|P-value:6.82E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.85|P-value:4.76E-5 ID:SGTC_2439|Compound:5492030|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.75|P-value:7.04E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.31|P-value:3.39E-8 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.76|P-value:5.58E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.72|P-value:3.04E-9 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.18|P-value:6.26E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.21|P-value:4.92E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-4.49|P-value:2.05E-6 ID:SGTC_2907|Compound:7721985|FD-Score:3.19|P-value:6.16E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.92|P-value:2.86E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.38|P-value:3.05E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.68|P-value:8.05E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.33|P-value:3.09E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:3.14|P-value:7.19E-4 ID:SGTC_406|Compound:estrone|FD-Score:4.58|P-value:1.68E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.06|P-value:9.63E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.06|P-value:9.70E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.20|P-value:5.89E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.08|P-value:9.05E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-5.18|P-value:5.47E-8 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.52|P-value:1.77E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.38|P-value:3.10E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.07|P-value:1.81E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.89|P-value:3.92E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.47|P-value:2.13E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.23|P-value:4.57E-4 ID:SGTC_1781|Compound:st038725|FD-Score:3.51|P-value:1.86E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.31|P-value:4.03E-4 ID:SGTC_1991|Compound:st073000|FD-Score:7.41|P-value:2.34E-14 ID:SGTC_1993|Compound:st073995|FD-Score:3.15|P-value:7.15E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.06|P-value:8.17E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.39|P-value:2.93E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.08|P-value:7.64E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.36|P-value:4.77E-6 ID:SGTC_2357|Compound:9067248|FD-Score:-3.12|P-value:6.82E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.85|P-value:4.76E-5 ID:SGTC_2439|Compound:5492030|FD-Score:3.32|P-value:3.84E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.75|P-value:7.04E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.31|P-value:3.39E-8 ID:SGTC_2686|Compound:alizarin|FD-Score:-3.76|P-value:5.58E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.72|P-value:3.04E-9 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.18|P-value:6.26E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.21|P-value:4.92E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-4.49|P-value:2.05E-6 ID:SGTC_2907|Compound:7721985|FD-Score:3.19|P-value:6.16E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.92|P-value:2.86E-5 ID:SGTC_3218|Compound:9131285|FD-Score:3.38|P-value:3.05E-4

Top fitness defect scores for YBR181C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1991 st073000 7.41 8.9 µM 2.34E-14 NEO1 19 6.29E-14
2 SGTC_2688 kanamycin b 5.72 96.7 µM 3.04E-9 calcium & mitochondrial duress 177 5.35E-9
3 SGTC_2639 lactacystin 5.31 53.0 µM 3.39E-8 8 5.47E-8
4 SGTC_2576 guaiol 4.75 23.1 µM 7.04E-7 8 1.02E-6
5 SGTC_406 estrone 4.58 100.0 µM 1.68E-6 5 2.37E-6
6 SGTC_1460 k062-0059 4.36 9.2 µM 4.77E-6 Golgi 7 6.49E-6
7 SGTC_2347 9049783 4.36 174.8 µM 4.77E-6 15 6.50E-6
8 SGTC_1365 1672-3266 4.07 55.4 µM 1.81E-5 15 2.36E-5
9 SGTC_1468 k284-1086 3.89 134.0 µM 3.92E-5 DNA intercalators 39 4.98E-5
10 SGTC_2376 9072922 3.85 81.3 µM 4.76E-5 32 6.01E-5
11 SGTC_1343 1487-0095 3.64 224.0 µM 1.13E-4 11 1.38E-4
12 SGTC_1328 1441-0025 3.52 69.2 µM 1.77E-4 13 2.14E-4
13 SGTC_1781 st038725 3.51 66.3 µM 1.86E-4 NEO1 122 2.25E-4
14 SGTC_1545 lovastatin 3.47 49.4 µM 2.13E-4 41 2.56E-4
15 SGTC_2789 5281112 3.40 71.4 µM 2.84E-4 66 3.38E-4
16 SGTC_2289 7946404 3.39 165.1 µM 2.93E-4 117 3.49E-4
17 SGTC_3218 9131285 3.38 49.5 µM 3.05E-4 endomembrane recycling 76 3.62E-4
18 SGTC_1348 1493-0373 3.38 93.8 µM 3.10E-4 28 3.68E-4
19 SGTC_2439 5492030 3.32 7.2 µM 3.84E-4 33 4.52E-4
20 SGTC_1984 st072354 3.31 53.1 µM 4.03E-4 30 4.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 9.21E-28 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.177 5.76E-25 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.154 2.58E-19 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.142 1.68E-16 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.138 9.67E-16 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.137 1.71E-15 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.135 3.41E-15 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.133 1.31E-14 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.131 2.57E-14 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
0.126 2.28E-13 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.124 6.32E-13 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.123 8.54E-13 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.120 3.01E-12 YDL115C IWR1 hom RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
0.116 1.48E-11 YOR006C TSR3 hom Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.114 3.88E-11 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication