YBR182C / SMP1

Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR182C / SMP1

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.03|P-value:7.86E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.07|P-value:6.98E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.60|P-value:8.92E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.46|P-value:1.58E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.24|P-value:5.30E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:3.31|P-value:2.80E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.00|P-value:9.01E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.15|P-value:5.13E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.48|P-value:1.44E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.15|P-value:5.20E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.30|P-value:2.91E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.25|P-value:3.59E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.74|P-value:5.08E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.05|P-value:7.44E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.02|P-value:8.17E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.72|P-value:5.57E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.44|P-value:2.16E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.04|P-value:1.32E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.42|P-value:1.85E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.19|P-value:5.46E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.26|P-value:3.43E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:5.58|P-value:3.55E-9 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.24|P-value:3.77E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.01|P-value:8.47E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.65|P-value:7.34E-5 ID:SGTC_1657|Compound:st012939|FD-Score:4.08|P-value:1.09E-5 ID:SGTC_1691|Compound:st019933|FD-Score:-3.41|P-value:2.37E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.11|P-value:7.22E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.53|P-value:1.21E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.07|P-value:8.53E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.68|P-value:8.24E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.90|P-value:2.47E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.27|P-value:4.09E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.72|P-value:5.37E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.56|P-value:1.11E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.41|P-value:1.92E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.81|P-value:3.66E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.27|P-value:3.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.35|P-value:2.41E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.98|P-value:9.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.95|P-value:2.60E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.21|P-value:4.15E-4 ID:SGTC_2947|Compound:9072639|FD-Score:5.32|P-value:1.72E-8 ID:SGTC_3133|Compound:9127736|FD-Score:3.37|P-value:2.29E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.18|P-value:6.98E-6 ID:SGTC_3316|Compound:9136639|FD-Score:3.01|P-value:8.69E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.31|P-value:3.55E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.13|P-value:5.51E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.03|P-value:7.86E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.07|P-value:6.98E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.60|P-value:8.92E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.46|P-value:1.58E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.24|P-value:5.30E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:3.31|P-value:2.80E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.00|P-value:9.01E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.15|P-value:5.13E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.48|P-value:1.44E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.15|P-value:5.20E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.30|P-value:2.91E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.25|P-value:3.59E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.74|P-value:5.08E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.05|P-value:7.44E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.02|P-value:8.17E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.54|P-value:1.14E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.72|P-value:5.57E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.44|P-value:2.16E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.04|P-value:1.32E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.42|P-value:1.85E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.19|P-value:5.46E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.26|P-value:3.43E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:5.58|P-value:3.55E-9 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.16|P-value:5.00E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.24|P-value:3.77E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.57|P-value:1.04E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.01|P-value:8.47E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.65|P-value:7.34E-5 ID:SGTC_1657|Compound:st012939|FD-Score:4.08|P-value:1.09E-5 ID:SGTC_1691|Compound:st019933|FD-Score:-3.41|P-value:2.37E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.11|P-value:7.22E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.53|P-value:1.21E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.07|P-value:8.53E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.68|P-value:8.24E-5 ID:SGTC_1975|Compound:st070967|FD-Score:3.48|P-value:1.49E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.90|P-value:2.47E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.27|P-value:4.09E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.72|P-value:5.37E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.56|P-value:1.11E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.41|P-value:1.92E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.81|P-value:3.66E-5 ID:SGTC_2714|Compound:st079313|FD-Score:3.27|P-value:3.35E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.35|P-value:2.41E-4 ID:SGTC_2788|Compound:5282734|FD-Score:2.98|P-value:9.50E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.95|P-value:2.60E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.21|P-value:4.15E-4 ID:SGTC_2947|Compound:9072639|FD-Score:5.32|P-value:1.72E-8 ID:SGTC_3133|Compound:9127736|FD-Score:3.37|P-value:2.29E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.07|P-value:7.01E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.18|P-value:6.98E-6 ID:SGTC_3316|Compound:9136639|FD-Score:3.01|P-value:8.69E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.31|P-value:3.55E-4

Top fitness defect scores for YBR182C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1305 1181-0477 5.58 144.0 µM 3.55E-9 5 1.21E-8
2 SGTC_2947 9072639 5.32 7.7 µM 1.72E-8 tubulin folding & SWR complex 14 5.28E-8
3 SGTC_2611 pyromycin 4.56 23.9 µM 1.11E-6 11 2.61E-6
4 SGTC_166 k072-0058 4.24 166.4 µM 5.30E-6 DNA intercalators 25 1.12E-5
5 SGTC_3225 9130819 4.18 49.5 µM 6.98E-6 amide catabolism 23 1.45E-5
6 SGTC_1657 st012939 4.08 43.4 µM 1.09E-5 8 2.21E-5
7 SGTC_1137 ixabepilone 4.04 100.0 µM 1.32E-5 21 2.64E-5
8 SGTC_2251 lansoprazole 3.90 556.0 µM 2.47E-5 21 4.74E-5
9 SGTC_2613 3',4'-dimethoxydalbergione 3.81 24.6 µM 3.66E-5 29 6.85E-5
10 SGTC_616 4092-0450 3.74 108.0 µM 5.08E-5 18 9.31E-5
11 SGTC_2603 homopterocarpin 3.72 100.0 µM 5.37E-5 53 9.80E-5
12 SGTC_965 1291-5240 3.72 308.0 µM 5.57E-5 37 1.01E-4
13 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.65 19.1 µM 7.34E-5 27 1.31E-4
14 SGTC_163 1327-0036 3.60 7.5 µM 8.92E-5 133 1.58E-4
15 SGTC_1409 3909-8004 3.57 61.9 µM 1.04E-4 29 1.81E-4
16 SGTC_774 k060-0086 3.54 136.0 µM 1.14E-4 32 1.98E-4
17 SGTC_1862 st057513 3.53 3.8 µM 1.21E-4 23 2.09E-4
18 SGTC_272 doxorubicin 3.48 8.1 µM 1.44E-4 anthracycline transcription coupled DNA repair 35 2.47E-4
19 SGTC_1975 st070967 3.48 30.8 µM 1.49E-4 49 2.55E-4
20 SGTC_164 4100-3994 3.46 89.6 µM 1.58E-4 49 2.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 3.32E-16 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.136 2.20E-15 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.114 3.12E-11 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.100 5.61E-9 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.094 5.34E-8 YGL031C RPL24A hom Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication
0.089 2.44E-7 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.087 4.10E-7 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 7.56E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.085 7.58E-7 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.084 1.19E-6 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.082 2.25E-6 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.079 4.74E-6 YFL004W VTC2 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.078 5.74E-6 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.076 9.19E-6 YOR352W TFB6 hom Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.076 1.07E-5 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque