HIPHOP chemogenomics database

YBR182C-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain

fixedexpanded
Profile for YBR182C-A / YBR182C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YBR182C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_145	3737-0113	6.14	38.4 µM	1.33E-9	DNA intercalators	27	4.07E-10
2	SGTC_184	1494-0393	6.03	24.7 µM	2.58E-9		18	8.23E-10
3	SGTC_1357	1503-1303	5.12	39.5 µM	3.63E-7		10	1.57E-7
4	SGTC_1926	methyl fluorone black	4.75	53.6 µM	2.15E-6	DNA intercalators	39	1.03E-6
5	SGTC_58	0957-0393	4.74	9.0 µM	2.24E-6	cell wall	314	1.08E-6
6	SGTC_2314	7727897	4.27	200.0 µM	1.78E-5		13	9.73E-6
7	SGTC_143	4032-1194	4.25	15.7 µM	1.95E-5		53	1.08E-5
8	SGTC_1981	st071826	4.22	47.0 µM	2.18E-5		11	1.21E-5
9	SGTC_1033	k072-0102	4.21	21.3 µM	2.26E-5	60S ribosome export	15	1.26E-5
10	SGTC_2191	5911152	4.07	200.0 µM	4.06E-5		11	2.33E-5
11	SGTC_1859	st055998	4.01	20.0 µM	5.23E-5		22	3.06E-5
12	SGTC_2305	7443522	4.00	69.2 µM	5.45E-5		14	3.19E-5
13	SGTC_9	0092-0002	3.92	10.4 µM	7.52E-5		27	4.50E-5
14	SGTC_1493	4348-0038	3.91	111.0 µM	7.59E-5	RSC complex & mRNA processing	28	4.54E-5
15	SGTC_35	0133-0054	3.90	64.1 µM	8.15E-5		36	4.89E-5
16	SGTC_1857	st056007	3.89	79.3 µM	8.26E-5		7	4.97E-5
17	SGTC_1889	st059080	3.83	5.2 µM	1.07E-4		21	6.51E-5
18	SGTC_2270	7924575	3.79	90.9 µM	1.20E-4	RPP1 & pyrimidine depletion	17	7.39E-5
19	SGTC_144	4161-2749	3.77	112.4 µM	1.33E-4	DNA intercalators	27	8.23E-5
20	SGTC_663	1486-0733	3.75	13.9 µM	1.43E-4	cell wall signaling	57	8.86E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.216	9.11E-37	YHR149C	SKG6	hom	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.201	6.72E-32	YDR401W_d	YDR401W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.184	7.25E-27	YNL124W	NAF1	het	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.183	1.61E-26	YPR059C_d	YPR059C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.176	1.08E-24	YEL064C	AVT2	hom	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.175	1.42E-24	YGR070W	ROM1	hom	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.175	1.80E-24	YMR044W	IOC4	hom	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.170	4.29E-23	YGL118C_d	YGL118C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.166	3.17E-22	YFL022C	FRS2	het	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.164	1.06E-21	YGL002W	ERP6	hom	Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.158	4.10E-20	YEL017C-A	PMP2	hom	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.157	6.78E-20	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.155	1.97E-19	YBL008W-A_p	YBL008W-A_p	hom	Putative protein of unknown function; identified by fungal homology and RT-PCR
0.151	1.25E-18	YNL151C	RPC31	het	RNA polymerase III subunit C31
0.149	4.87E-18	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm