YBR191W / RPL21A

Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR191W / RPL21A

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.68|P-value:3.49E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.48|P-value:6.64E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.46|P-value:7.93E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.53|P-value:9.83E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:4.13|P-value:7.23E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:3.36|P-value:9.62E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.17|P-value:6.18E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.36|P-value:3.43E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.75|P-value:2.79E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.96|P-value:1.31E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:8.00|P-value:9.80E-14 ID:SGTC_689|Compound:0833-0039|FD-Score:3.53|P-value:5.73E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.75|P-value:6.27E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.98|P-value:2.30E-6 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.58|P-value:4.91E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.16|P-value:7.23E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.80|P-value:2.35E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.81|P-value:2.26E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.66|P-value:4.14E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.47|P-value:7.75E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.59|P-value:5.21E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-5.04|P-value:2.09E-6 ID:SGTC_1726|Compound:st035556|FD-Score:-5.09|P-value:1.64E-6 ID:SGTC_1920|Compound:st075728|FD-Score:4.26|P-value:4.40E-5 ID:SGTC_1966|Compound:st070145|FD-Score:3.72|P-value:3.01E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.39|P-value:8.80E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.48|P-value:6.71E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.82|P-value:4.65E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.74|P-value:3.18E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:6.75|P-value:2.71E-10 ID:SGTC_2456|Compound:5770359|FD-Score:3.36|P-value:9.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.97|P-value:1.44E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.12|P-value:7.47E-5 ID:SGTC_2788|Compound:5282734|FD-Score:8.17|P-value:2.92E-14 ID:SGTC_2997|Compound:9067075|FD-Score:-3.72|P-value:3.43E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.68|P-value:3.49E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.48|P-value:6.64E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.46|P-value:7.93E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.53|P-value:9.83E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:4.13|P-value:7.23E-5 ID:SGTC_291|Compound:4130-1278|FD-Score:3.36|P-value:9.62E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.17|P-value:6.18E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.36|P-value:3.43E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.75|P-value:2.79E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.96|P-value:1.31E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:8.00|P-value:9.80E-14 ID:SGTC_689|Compound:0833-0039|FD-Score:3.53|P-value:5.73E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.75|P-value:6.27E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.98|P-value:2.30E-6 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.58|P-value:4.91E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.16|P-value:7.23E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.80|P-value:2.35E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.81|P-value:2.26E-4 ID:SGTC_1548|Compound:st061468|FD-Score:-3.66|P-value:4.14E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-3.47|P-value:7.75E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.59|P-value:5.21E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-5.04|P-value:2.09E-6 ID:SGTC_1726|Compound:st035556|FD-Score:-5.09|P-value:1.64E-6 ID:SGTC_1920|Compound:st075728|FD-Score:4.26|P-value:4.40E-5 ID:SGTC_1966|Compound:st070145|FD-Score:3.72|P-value:3.01E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.39|P-value:8.80E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.48|P-value:6.71E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.82|P-value:4.65E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.74|P-value:3.18E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:6.75|P-value:2.71E-10 ID:SGTC_2456|Compound:5770359|FD-Score:3.36|P-value:9.87E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.97|P-value:1.44E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.12|P-value:7.47E-5 ID:SGTC_2788|Compound:5282734|FD-Score:8.17|P-value:2.92E-14 ID:SGTC_2997|Compound:9067075|FD-Score:-3.72|P-value:3.43E-4

Top fitness defect scores for YBR191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2788 5282734 8.17 71.4 µM 2.92E-14 4 1.51E-16
2 SGTC_625 k213-0058 8.00 121.0 µM 9.80E-14 translation 11 6.31E-16
3 SGTC_2422 chlorphenesin carbamate 6.75 384.2 µM 2.71E-10 3 7.39E-12
4 SGTC_118 0083-0097 6.53 135.3 µM 9.83E-10 translation 11 3.40E-11
5 SGTC_832 4083-0019 4.98 164.0 µM 2.30E-6 translation 41 3.20E-7
6 SGTC_2370 9071495 4.82 200.0 µM 4.65E-6 mitochondrial processes 11 7.34E-7
7 SGTC_800 3448-7362 4.75 155.0 µM 6.27E-6 translation 101 1.04E-6
8 SGTC_1920 st075728 4.26 45.7 µM 4.40E-5 17 1.03E-5
9 SGTC_312 4092-0653 4.17 6.8 µM 6.18E-5 ergosterol depletion effects on membrane 77 1.54E-5
10 SGTC_168 3970-0862 4.13 530.5 µM 7.23E-5 110 1.85E-5
11 SGTC_2688 kanamycin b 4.12 96.7 µM 7.47E-5 calcium & mitochondrial duress 345 1.92E-5
12 SGTC_620 0109-0052 3.96 432.0 µM 1.31E-4 18 3.72E-5
13 SGTC_1426 4048-4480 3.81 71.7 µM 2.26E-4 60S ribosome export 22 7.05E-5
14 SGTC_1312 1218-2183 3.80 165.0 µM 2.35E-4 12 7.35E-5
15 SGTC_518 1021-0119 3.75 62.6 µM 2.79E-4 ERG2 56 9.01E-5
16 SGTC_1966 st070145 3.72 16.1 µM 3.01E-4 28 9.85E-5
17 SGTC_87 0100-0052 3.68 35.5 µM 3.49E-4 133 1.17E-4
18 SGTC_1151 3909-8316 3.58 15.3 µM 4.91E-4 28 1.75E-4
19 SGTC_689 0833-0039 3.53 98.0 µM 5.73E-4 ergosterol depletion effects on membrane 40 2.09E-4
20 SGTC_100 0086-0128 3.48 49.6 µM 6.64E-4 copper-dependent oxidative stress 76 2.49E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 4.03E-38 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.185 2.89E-27 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.182 2.93E-26 YGR214W RPS0A hom Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.180 6.53E-26 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.171 1.94E-23 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.167 1.65E-22 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.164 9.37E-22 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.162 4.33E-21 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.160 8.83E-21 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.158 2.87E-20 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.157 7.08E-20 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.156 1.44E-19 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.153 6.13E-19 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.150 2.30E-18 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.150 2.44E-18 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay